Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology (Q37680075)

21 August 2017

Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology (English)

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21 August 2017

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Rochelle Buffenstein

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21 August 2017

Miranda E Orr

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21 August 2017

Angelica Salinas

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2

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21 August 2017

Salvatore Oddo

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21 August 2017

14 December 2013

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21 August 2017

Neurobiology of Aging

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21 August 2017

35

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21 August 2017

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21 August 2017

1233-1242

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describes a project that uses

21 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3973159/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Insulin, cognition, and dementia

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Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.

23 August 2017

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Duration of rapamycin treatment has differential effects on metabolism in mice

23 August 2017

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mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies.

23 August 2017

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23 August 2017

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Rapamycin delays disease onset and prevents PrP plaque deposition in a mouse model of Gerstmann-Sträussler-Scheinker disease

23 August 2017

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23 August 2017

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Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

23 August 2017

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Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

23 August 2017

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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

23 August 2017

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23 August 2017

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Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

23 August 2017

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The role of mTOR signaling in Alzheimer disease

23 August 2017

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Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits

23 August 2017

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Resveratrol inhibits Cdk5 activity through regulation of p35 expression

23 August 2017

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Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism

23 August 2017

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Methylene blue reduces aβ levels and rescues early cognitive deficit by increasing proteasome activity

23 August 2017

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

23 August 2017

1 reference

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Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes

23 August 2017

1 reference

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Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

23 August 2017

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23 August 2017

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Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease

23 August 2017

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Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice

23 August 2017

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Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

23 August 2017

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Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease

23 August 2017

1 reference

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Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway

23 August 2017

1 reference

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

23 August 2017

1 reference

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Common pathological processes and transcriptional pathways in Alzheimer's disease and type 2 diabetes

23 August 2017

1 reference

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mTOR-dependent signalling in Alzheimer's disease

23 August 2017

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

23 August 2017

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TOR signaling in growth and metabolism

23 August 2017

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Risk of dementia in diabetes mellitus: a systematic review

23 August 2017

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Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine

23 August 2017

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Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

23 August 2017

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Tau, tangles, and Alzheimer's disease

23 August 2017

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

23 August 2017

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p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

23 August 2017

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Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

A Central role for mTOR in lipid homeostasis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

mTOR and regulation of energy homeostasis in humans

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

Tau protein kinases: involvement in Alzheimer's disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

Insulin resistance due to nutrient excess: is it a consequence of AMPK downregulation?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

How does diabetes accelerate Alzheimer disease pathology?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

Glucose-induced expression of the cyclin-dependent protein kinase 5 activator p35 involved in Alzheimer's disease regulates insulin gene transcription in pancreatic beta-cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

Insulin-resistant brain state after intracerebroventricular streptozotocin injection exacerbates Alzheimer-like changes in Tg2576 AbetaPP-overexpressing mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer's disease and correction by insulin

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

Cleavage of GSK-3β by calpain counteracts the inhibitory effect of Ser9 phosphorylation on GSK-3β activity induced by H₂O₂.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

Amyloid-β and tau pathology of Alzheimer's disease induced by diabetes in a rabbit animal model.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

Chronic peripheral hyperinsulinemia has no substantial influence on tau phosphorylation in vivo.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

Increased Aβ production prompts the onset of glucose intolerance and insulin resistance.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

Increased Cdk5/p35 activity in the dentate gyrus mediates depressive-like behaviour in rats.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

Diabetes mellitus and the risk of dementia: The Rotterdam Study.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

A brain-specific activator of cyclin-dependent kinase 5.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973159

10.1016/J.NEUROBIOLAGING.2013.12.006

1 September 2018

Identifiers

DOI

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21 August 2017

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21 August 2017

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