The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides (Q37724167)

22 August 2017

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title

The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides (English)

1 reference

22 August 2017

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Leaf Huang

1

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PubMed ID

20367081

22 August 2017

Bruce Sullenger

series ordinal

2

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PubMed ID

20367081

22 August 2017

Rudy Juliano

series ordinal

3

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22 August 2017

1 September 2010

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Journal of Drug Targeting

22 August 2017

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22 August 2017

18

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22 August 2017

567-574

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22 August 2017

8

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Nonviral delivery of synthetic siRNAs in vivo

22 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Pharmacokinetics, biodistribution, stability and toxicity of a cell-penetrating peptide-morpholino oligomer conjugate.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Expression of functionally active FcRn and the differentiated bidirectional transport of IgG in human placental endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Biodistribution of phosphodiester and phosphorothioate siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

The promises and pitfalls of RNA-interference-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Insulin receptor substrate 1 knockdown in human MCF7 ER+ breast cancer cells by nuclease-resistant IRS1 siRNA conjugated to a disulfide-bridged D-peptide analogue of insulin-like growth factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Particle shape: a new design parameter for micro- and nanoscale drug delivery carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Shape induced inhibition of phagocytosis of polymer particles

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Polymersome carriers: from self-assembly to siRNA and protein therapeutics.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Flexible filaments for in vivo imaging and delivery: persistent circulation of filomicelles opens the dosage window for sustained tumor shrinkage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Aptamer mediated siRNA delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Progress in antisense technology.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Intravascular delivery of particulate systems: does geometry really matter?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Influence of poly(ethylene glycol) grafting density and polymer length on liposomes: relating plasma circulation lifetimes to protein binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Imparting size, shape, and composition control of materials for nanomedicine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Stabilized plasmid-lipid particles: a systemic gene therapy vector

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Calculation of hydrodynamic properties of small nucleic acids from their atomic structure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Recent advances in the use of cell-penetrating peptides for medical and biological applications

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Shape effects of filaments versus spherical particles in flow and drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

The effect of particle design on cellular internalization pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Enhanced permeability and retention of macromolecular drugs in solid tumors: a royal gate for targeted anticancer nanomedicines.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Pharmacokinetics and biodistribution of novel aptamer compositions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Novel long-circulating lipid nanocapsules

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Exploiting the enhanced permeability and retention effect for tumor targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Transport of molecules, particles, and cells in solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Drug delivery and transport to solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Sustained dystrophin expression induced by peptide-conjugated morpholino oligomers in the muscles of mdx mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Cellular delivery and biological activity of antisense oligonucleotides conjugated to a targeted protein carrier

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Molecular mechanisms of endothelial hyperpermeability: implications in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Cell penetrating peptide conjugates of steric block oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Tumor-targeted delivery of siRNA by self-assembled nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Role of liposome size and RES blockade in controlling biodistribution and tumor uptake of GM1-containing liposomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

In vivo selection of tumor-targeting RNA motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Targeting Stealth liposomes in a murine model of human small cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Aptamers: an emerging class of therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Factors affecting drug and gene delivery: effects of interaction with blood components

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Anti-MUC1 aptamers: radiolabelling with (99m)Tc and biodistribution in MCF-7 tumour-bearing mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Gene therapy progress and prospects: RNA aptamers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Transendothelial transport: the vesicle controversy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

FcRn: the neonatal Fc receptor comes of age.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Intravenously administered short interfering RNA accumulates in the kidney and selectively suppresses gene function in renal proximal tubules.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Anti-L-selectin aptamers: binding characteristics, pharmacokinetic parameters, and activity against an intravascular target in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Mechanisms and optimization of in vivo delivery of lipophilic siRNAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Tissue disposition of 2'-O-(2-methoxy) ethyl modified antisense oligonucleotides in monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

The therapeutic potential of cell-internalizing aptamers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10611861003734019

10.3109/10611861003734019

21 January 2018

Identifiers

DOI

1 reference

22 August 2017

1 reference

PubMed ID

20367081