Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes (Q37734367)

22 August 2017

Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes (English)

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22 August 2017

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murine leukemia virus

object named as

murine leukemia virus

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10

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22 August 2017

11

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Mamuka Kvaratskhelia

12

object named as

Mamuka Kvaratskhelia

1 reference

22 August 2017

Ross C Larue

1

1 reference

22 August 2017

Matthew R Plumb

2

1 reference

22 August 2017

Brandon L Crowe

3

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22 August 2017

Nikoloz Shkriabai

4

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22 August 2017

Amit Sharma

5

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22 August 2017

Julia DiFiore

6

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22 August 2017

Nirav Malani

7

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22 August 2017

Sriram S Aiyer

8

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22 August 2017

Monica J Roth

9

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22 August 2017

language of work or name

English

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publication date

11 February 2014

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22 August 2017

Nucleic Acids Research

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22 August 2017

42

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22 August 2017

8

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22 August 2017

4868-4881

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Creative Commons Attribution 3.0 Unported

22 August 2017

start time

4 October 2016

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4005663/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites

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Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration

22 August 2017

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BET proteins promote efficient murine leukemia virus integration at transcription start sites

22 August 2017

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Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

22 August 2017

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Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting

22 August 2017

1 reference

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Proteogenomic characterization and mapping of nucleosomes decoded by Brd and HP1 proteins.

22 August 2017

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Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2)

22 August 2017

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BET domain co-regulators in obesity, inflammation and cancer

22 August 2017

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Gene therapy for primary immunodeficiencies

22 August 2017

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Histone recognition and large-scale structural analysis of the human bromodomain family

22 August 2017

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Retroviral integrations in gene therapy trials

22 August 2017

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Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

22 August 2017

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HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2

22 August 2017

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Stem-cell gene therapy for the Wiskott-Aldrich syndrome

22 August 2017

1 reference

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Selective inhibition of BET bromodomains

22 August 2017

1 reference

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Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration

22 August 2017

1 reference

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Retroviral intasome assembly and inhibition of DNA strand transfer

22 August 2017

1 reference

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Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

22 August 2017

1 reference

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Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005663

Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution

22 August 2017

1 reference

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Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

22 August 2017

1 reference

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Structural basis for functional tetramerization of lentiviral integrase

22 August 2017

1 reference

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Integration target site selection by a resurrected human endogenous retrovirus

22 August 2017

1 reference

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Mass spectrometry-based footprinting of protein-protein interactions

22 August 2017

1 reference

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Solution structure of the extraterminal domain of the bromodomain-containing protein BRD4.

22 August 2017

1 reference

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Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

22 August 2017

1 reference

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Host proteins interacting with the Moloney murine leukemia virus integrase: multiple transcriptional regulators and chromatin binding factors

22 August 2017

1 reference

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LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

22 August 2017

1 reference

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The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation

22 August 2017

1 reference

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Selection of target sites for mobile DNA integration in the human genome

22 August 2017

1 reference

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Development of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome.

22 August 2017

1 reference

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An essential role for LEDGF/p75 in HIV integration

22 August 2017

1 reference

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Retroviral DNA integration: viral and cellular determinants of target-site selection

22 August 2017

1 reference

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Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

22 August 2017

1 reference

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A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

22 August 2017

1 reference

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Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

22 August 2017

1 reference

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Integration targeting by avian sarcoma-leukosis virus and human immunodeficiency virus in the chicken genome

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005663

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005663

The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005663

Transcription start regions in the human genome are favored targets for MLV integration

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005663

HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005663

HIV-1 integration in the human genome favors active genes and local hotspots

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005663

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005663

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005663

Mutational analysis of the carboxyl terminus of the Moloney murine leukemia virus integration protein

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005663

Gene therapy for primary adaptive immune deficiencies

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005663

The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005663

Reactivation of latent HIV-1 by inhibition of BRD4.

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005663

A role for LEDGF/p75 in targeting HIV DNA integration

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005663

BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005663

Gammaretroviral integration into nucleosomal target DNA in vivo

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005663

Characterization of the forward and reverse integration reactions of the Moloney murine leukemia virus integrase protein purified from Escherichia coli

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005663

Polyclonal long-term repopulating stem cell clones in a primate model

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005663

Identification by NMR of the binding surface for the histidine-containing phosphocarrier protein HPr on the N-terminal domain of enzyme I of the Escherichia coli phosphotransferase system.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005663

1 September 2018

Identifiers

DOI

10.1093/NAR/GKU135

1 reference

22 August 2017

1 reference

22 August 2017

PubMed publication ID

24520112

1 reference