Rational therapeutic approaches to progressive supranuclear palsy (Q37753509)

22 August 2017

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title

Rational therapeutic approaches to progressive supranuclear palsy (English)

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22 August 2017

6

Wolfgang H Oertel

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22 August 2017

1

Maria Stamelou

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22 August 2017

Rohan de Silva

2

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22 August 2017

Oscar Arias-Carrión

3

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22 August 2017

Evangelia Boura

4

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22 August 2017

Matthias Höllerhage

5

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22 August 2017

Ulrich Müller

7

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22 August 2017

Günter U Höglinger

8

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22 August 2017

language of work or name

English

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publication date

14 May 2010

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22 August 2017

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22 August 2017

133

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22 August 2017

Pt 6

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22 August 2017

1578-1590

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Clinical and neuropathologic features of progressive supranuclear palsy with severe pallido-nigro-luysial degeneration and axonal dystrophy

22 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Evidence for oxidative stress in the subthalamic nucleus in progressive supranuclear palsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Further evidence for mitochondrial dysfunction in progressive supranuclear palsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Mitochondrial dysfunction in progressive supranuclear palsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Atypical parkinsonism and Annonaceae consumption in New Caledonia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Association of an extended haplotype in the tau gene with progressive supranuclear palsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Positron emission tomography study in progressive supranuclear palsy. Brain hypometabolic pattern and clinicometabolic correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Incidence of progressive supranuclear palsy and multiple system atrophy in Olmsted County, Minnesota, 1976 to 1990.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Development of tau aggregation inhibitors for Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Progressive supranuclear palsy: where are we now?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Differential diagnosis of Parkinson's disease, multiple system atrophy, and Steele-Richardson-Olszewski syndrome: discriminant analysis of striatal 18F-dopa PET data

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Haplotype-specific expression of exon 10 at the human MAPT locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Haplotype-specific expression of the N-terminal exons 2 and 3 at the human MAPT locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Expression and activity of antioxidants in the brain in progressive supranuclear palsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Guadeloupean parkinsonism: a cluster of progressive supranuclear palsy-like tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Geographic isolates of atypical Parkinsonism and tauopathy in the tropics: possible synergy of neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Mammalian MAP kinase signalling cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Stress-induced mitochondrial depolarization and oxidative damage in PSP cybrids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Therapeutic effects of coenzyme Q10 (CoQ10) and reduced CoQ10 in the MPTP model of Parkinsonism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Genetic evidence for the involvement of tau in progressive supranuclear palsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

5'-Upstream variants of CRHR1 and MAPT genes associated with age at onset in progressive supranuclear palsy and cortical basal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

The clinical and pathological spectrum of Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy): a reappraisal

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Familial progressive supranuclear palsy. Description of a pedigree and review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Early diagnosis of dementia: neuropsychology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

A femtomolar acting octapeptide interacts with tubulin and protects astrocytes against zinc intoxication

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Peptide neuroprotection through specific interaction with brain tubulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Stabilization of the tau exon 10 stem loop alters pre-mRNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Identification of tau stem loop RNA stabilizers

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Chaperones increase association of tau protein with microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Abnormal metabolic networks in atypical parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Identification of a novel polymorphism in the promoter region of the tau gene highly associated to progressive supranuclear palsy in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Pyruvate protects cerebellar granular cells from 6-hydroxydopamine-induced cytotoxicity by activating the Akt signaling pathway and increasing glutathione peroxidase expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

A clinical rating scale for progressive supranuclear palsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

NAP, a neuroprotective drug candidate in clinical trials, stimulates microtubule assembly in the living cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Evidence suggesting that Homo neanderthalensis contributed the H2 MAPT haplotype to Homo sapiens

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Natural lipophilic inhibitors of mitochondrial complex I are candidate toxins for sporadic neurodegenerative tau pathologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Alzheimer's associated variant ubiquitin causes inhibition of the 26S proteasome and chaperone expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Failure in heat-shock protein expression in response to UBB+1 protein in progressive supranuclear palsy in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Voxel-based comparison of regional cerebral glucose metabolism between PSP and corticobasal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Widespread spinal cord involvement in progressive supranuclear palsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Oxidative stress and the pathogenesis of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

The glamour and gloom of glycogen synthase kinase-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Atypical progressive supranuclear palsy underlying progressive apraxia of speech and nonfluent aphasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Different metabolic patterns analysis of Parkinsonism on the 18F-FDG PET.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Cerebral glucose metabolism in corticobasal degeneration comparison with progressive supranuclear palsy using statistical mapping analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Frontal presentation in progressive supranuclear palsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Familial aggregation of parkinsonism in progressive supranuclear palsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Subcortical damage and cortical dysfunction in progressive supranuclear palsy demonstrated by positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Atypical parkinsonism in Guadeloupe: a common risk factor for two closely related phenotypes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Mitoxantrone analogues as ligands for a stem-loop structure of tau pre-mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Creatine and cyclocreatine attenuate MPTP neurotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Coenzyme Q10 reduces the toxicity of rotenone in neuronal cultures by preserving the mitochondrial membrane potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse substantia nigra.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Mitochondrial membrane depolarization and the selective death of dopaminergic neurons by rotenone: protective effect of coenzyme Q10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Mental rotation of perspective stimuli in a California sea lion (Zalophus californianus).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

The prevalence of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) in the UK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Familial atypical progressive supranuclear palsy associated with homozigosity for the delN296 mutation in the tau gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

An R5L tau mutation in a subject with a progressive supranuclear palsy phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Role of mitochondrial dysfunction in the pathogenesis of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

High-density SNP haplotyping suggests altered regulation of tau gene expression in progressive supranuclear palsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Progressive supranuclear palsy: clinical features, pathophysiology and management

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Phosphorylation Sites on Tau Identified by Nanoelectrospray Mass Spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

A new mutation of the tau gene, G303V, in early-onset familial progressive supranuclear palsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Genetic linkage of autosomal dominant progressive supranuclear palsy to 1q31.1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Tau interaction with microtubules in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Mitochondrial dysfunction in neurodegenerative diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Prevalence of progressive supranuclear palsy and multiple system atrophy: a cross-sectional study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Linkage disequilibrium and association of MAPT H1 in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

In vivo evidence for cerebral depletion in high-energy phosphates in progressive supranuclear palsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Short-term effects of coenzyme Q10 in progressive supranuclear palsy: a randomized, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Progressive supranuclear palsy pathology caused by a novel silent mutation in exon 10 of the tau gene: expansion of the disease phenotype caused by tau gene mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

A common inversion under selection in Europeans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Mitochondrial dysfunction in cybrid lines expressing mitochondrial genes from patients with progressive supranuclear palsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Increased tau burden in the cortices of progressive supranuclear palsy presenting with corticobasal syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Structural basis for recognition of the RNA major groove in the tau exon 10 splicing regulatory element by aminoglycoside antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Pyruvate protects mitochondria from oxidative stress in human neuroblastoma SK-N-SH cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Pure akinesia with gait freezing: a third clinical phenotype of progressive supranuclear palsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Targeting RNA: new opportunities to address drugless targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

The Tau Gene Haplotype H1 Confers a Susceptibility to Parkinson’s Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Structural Basis for Stabilization of the Tau Pre-mRNA Splicing Regulatory Element by Novantrone (Mitoxantrone)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

Significant Changes in the Tau A0 and A3 Alleles in Progressive Supranuclear Palsy and Improved Genotyping by Silver Detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWQ115

21 January 2018

Identifiers

DOI

10.1093/BRAIN/AWQ115

1 reference

22 August 2017

1 reference