Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer (Q37769360)

22 August 2017

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title

Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer (English)

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22 August 2017

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R Ariel Igal

1

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PubMed ID

20595235

22 August 2017

language of work or name

English

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publication date

1 July 2010

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22 August 2017

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22 August 2017

31

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22 August 2017

1509-1515

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22 August 2017

9

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Regulation of stearoyl-CoA desaturases and role in metabolism

22 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

The N terminus of microsomal delta 9 stearoyl-CoA desaturase contains the sequence determinant for its rapid degradation

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Ubiquitin-proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase.

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Enzymes of triacylglycerol synthesis and their regulation

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Stearoyl-coenzyme A desaturase 1 inhibition and the metabolic syndrome: considerations for future drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Role of stearoyl-CoA desaturases in obesity and the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Transcription of the CTP:phosphocholine cytidylyltransferase alpha gene is enhanced during the S phase of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Phospholipase D1b and D2a generate structurally identical phosphatidic acid species in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

LIPID arrays: new tools in the understanding of membrane dynamics and lipid signaling

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Regulation of stearoyl coenzyme A desaturase expression in human retinal pigment epithelial cells by retinoic acid

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Transforming growth factor-beta regulates stearoyl coenzyme A desaturase expression through a Smad signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Fatty acid synthesis: a potential selective target for antineoplastic therapy

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Tumour phospholipid metabolism

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Fatty acid synthase and cancer: new application of an old pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Regulation of fatty acid synthesis and Delta9-desaturation in senescence of human fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Akt stimulates aerobic glycolysis in cancer cells

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

ATP citrate lyase is an important component of cell growth and transformation

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

ATP citrate lyase inhibition can suppress tumor cell growth

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Detection of early gene expression changes by differential display in the livers of mice exposed to dichloroacetic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Erythrocyte membrane fatty acids and subsequent breast cancer: a prospective Italian study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Association between serum trans-monounsaturated fatty acids and breast cancer risk in the E3N-EPIC Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Fatty acid proportions in cholesterol esters and risk of premature death from cancer in middle aged French men

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Lipotoxicity: when tissues overeat

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Fatty acid synthase: a metabolic oncogene in prostate cancer?

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Akt-dependent transformation: there is more to growth than just surviving

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

AMPK in Health and Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Protein sensors for membrane sterols

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

GSK-3: tricks of the trade for a multi-tasking kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

The regulation of acetyl-CoA carboxylase--a potential target for the action of hypolipidemic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: a role for oxidant stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ131

21 January 2018

Identifiers

DOI

10.1093/CARCIN/BGQ131

1 reference

22 August 2017

1 reference

PubMed ID

20595235