Inherited Defects of Immunoglobulin Class Switch Recombination (Q37778043)

23 August 2017

1 reference

title

Inherited defects of immunoglobulin class switch recombination (English)

1 reference

23 August 2017

Inherited Defects of Immunoglobulin Class Switch Recombination (English)

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

17 June 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20687504

17 June 2024

genetic recombination

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20687504

17 June 2024

3

Anne Durandy

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20687504

17 June 2024

author name string

Sven Kracker

1

1 reference

23 August 2017

Pauline Gardës

2

1 reference

23 August 2017

language of work or name

English

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publication date

1 January 2010

1 reference

full work available at URL

23 August 2017

http://link.springer.com/content/pdf/10.1007/978-1-4419-6448-9_15

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Advances in Experimental Medicine and Biology

17 June 2024

published in

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23 August 2017

volume

685

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23 August 2017

page(s)

166-174

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Somatic generation of antibody diversity

23 August 2017

cites work

1

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Unique and unprecedented recombination mechanisms in class switching

17 June 2024

2

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Progress in understanding the mechanism and consequences of somatic hypermutation

17 June 2024

3

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Clonal selection and learning in the antibody system

17 June 2024

4

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https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Follicular B helper T cells in antibody responses and autoimmunity.

17 June 2024

5

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

17 June 2024

6

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM.

17 June 2024

7

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling

17 June 2024

8

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

17 June 2024

9

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

The AID enzyme induces class switch recombination in fibroblasts

17 June 2024

10

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

17 June 2024

11

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

17 June 2024

12

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase

17 June 2024

13

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks

17 June 2024

14

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Proteasomal degradation restricts the nuclear lifespan of AID

17 June 2024

15

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

17 June 2024

16

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

17 June 2024

17

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

17 June 2024

18

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

17 June 2024

19

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

AID mediates hypermutation by deaminating single stranded DNA.

17 June 2024

20

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

17 June 2024

21

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

17 June 2024

22

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

17 June 2024

23

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

17 June 2024

24

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.

17 June 2024

25

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation

17 June 2024

26

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination

17 June 2024

27

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

17 June 2024

28

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora

17 June 2024

29

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Clinical, immunologic and genetic analysis of 29 patients with autosomal recessive hyper-IgM syndrome due to Activation-Induced Cytidine Deaminase deficiency

17 June 2024

30

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch mu region

17 June 2024

31

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

AID mutant analyses indicate requirement for class-switch-specific cofactors

17 June 2024

32

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.

17 June 2024

33

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Analysis of class switch recombination and somatic hypermutation in patients affected with autosomal dominant hyper-IgM syndrome type 2.

17 June 2024

34

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

17 June 2024

35

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.

17 June 2024

36

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

17 June 2024

37

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.

17 June 2024

38

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability

17 June 2024

39

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation

17 June 2024

40

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes

17 June 2024

41

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

17 June 2024

42

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil

17 June 2024

43

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas

17 June 2024

44

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination.

17 June 2024

45

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.

17 June 2024

46

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes

17 June 2024

47

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions

17 June 2024

48

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Endonucleolytic function of MutLalpha in human mismatch repair

17 June 2024

49

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair

17 June 2024

50

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Human PMS2 deficiency is associated with impaired immunoglobulin class switch recombination

17 June 2024

51

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

PMS2 mutations in childhood cancer

17 June 2024

52

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Childhood T-cell non-Hodgkin's lymphoma, colorectal carcinoma and brain tumor in association with café-au-lait spots caused by a novel homozygous PMS2 mutation

17 June 2024

53

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice

17 June 2024

54

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair

17 June 2024

55

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase

17 June 2024

56

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

17 June 2024

57

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Genomic instability in mice lacking histone H2AX

17 June 2024

58

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

17 June 2024

59

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

ATM is required for efficient recombination between immunoglobulin switch regions

17 June 2024

60

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Nibrin functions in Ig class-switch recombination

17 June 2024

61

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

17 June 2024

62

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Ku80 is required for immunoglobulin isotype switching

17 June 2024

63

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

17 June 2024

64

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Delineation of the role of the Mre11 complex in class switch recombination

17 June 2024

66

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

ATM is not required in somatic hypermutation of VH, but is involved in the introduction of mutations in the switch mu region

17 June 2024

67

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutation

17 June 2024

68

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

IgH class switching and translocations use a robust non-classical end-joining pathway

17 June 2024

69

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells.

17 June 2024

70

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination.

17 June 2024

71

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Processing of switch transcripts is required for targeting of antibody class switch recombination

17 June 2024

72

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

17 June 2024

73

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

Somatic hypermutation in the heavy chain locus correlates with transcription

17 June 2024

74

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6448-9_15

17 June 2024

Identifiers

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20687504

17 June 2024

1 reference