Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions (Q37781814)

23 August 2017

title

Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions (English)

1 reference

23 August 2017

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Lisa Foa

6

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author name string

David W Klaver

1

1 reference

23 August 2017

Matthew C J Wilce

2

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23 August 2017

Hao Cui

3

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23 August 2017

Amos C Hung

4

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23 August 2017

Robert Gasperini

5

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23 August 2017

David H Small

7

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23 August 2017

publication date

1 August 2010

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23 August 2017

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23 August 2017

volume

391

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23 August 2017

issue

8

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23 August 2017

page(s)

849-859

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Heparin activates beta-secretase (BACE1) of Alzheimer's disease and increases autocatalysis of the enzyme.

23 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Neuregulin 1-erbB signaling is necessary for normal myelination and sensory function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

IFN-gamma-induced BACE1 expression is mediated by activation of JAK2 and ERK1/2 signaling pathways and direct binding of STAT1 to BACE1 promoter in astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

RAGE regulates BACE1 and Abeta generation via NFAT1 activation in Alzheimer's disease animal model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Prediction of the tertiary structure of the beta-secretase zymogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Emerging Alzheimer's disease therapies: inhibition of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Neuroinflammation in plaque and vascular beta-amyloid disorders: clinical and therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Levels of beta-secretase BACE and alpha-secretase ADAM10 mRNAs in Alzheimer hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Calcium enhances the proteolytic activity of BACE1: An in vitro biophysical and biochemical characterization of the BACE1-calcium interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

GGA proteins mediate the recycling pathway of memapsin 2 (BACE).

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Mapping of interaction domains mediating binding between BACE1 and RTN/Nogo proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

The membrane topology of RTN3 and its effect on binding of RTN3 to BACE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Increased beta-Secretase activity in cerebrospinal fluid of Alzheimer's disease subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

CSF BACE1 activity is increased in CJD and Alzheimer disease versus [corrected] other dementias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

First episodes of behavioral symptoms in Alzheimer's disease patients at age 90 and over, and early-onset Alzheimer's disease: comparison with senile dementia of Alzheimer's type

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Bace1 modulates myelination in the central and peripheral nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Cell biology, regulation and inhibition of beta-secretase (BACE-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Characterization of the ectodomain shedding of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

BACE1 regulates voltage-gated sodium channels and neuronal activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Glycosaminoglycan-induced activation of the beta-secretase (BACE1) of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Determination of dissociation constants for a heparin-binding domain of amyloid precursor protein and heparins or heparan sulfate by affinity capillary electrophoresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Axonal neuregulin-1 regulates myelin sheath thickness

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

SCN1A mutations and epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

The transcription factor Yin Yang 1 is an activator of BACE1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Regulation of APP cleavage by alpha-, beta- and gamma-secretases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

BACE (beta-secretase) modulates the processing of APLP2 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Calcium ionophore increases amyloid beta peptide production by cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Increasing neurite outgrowth capacity of beta-amyloid precursor protein proteoglycan in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Reduced amyloid deposition in mice overexpressing RTN3 is adversely affected by preformed dystrophic neurites

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Boom in the development of non-peptidic beta-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Understanding BACE1: essential protease for amyloid-beta production in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Beta-galactoside alpha2,6-sialyltransferase I cleavage by BACE1 enhances the sialylation of soluble glycoproteins. A novel regulatory mechanism for alpha2,6-sialylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Protective effects of NSAIDs on the development of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Phosphorylation regulates intracellular trafficking of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Control of peripheral nerve myelination by the beta-secretase BACE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

The yeast homolog of mammalian ribosomal protein S30 is expressed from a duplicated gene without a ubiquitin-like protein fusion sequence. Evolutionary implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

Solution Conformation and Heparin-induced Dimerization of the Full-length Extracellular Domain of the Human Amyloid Precursor Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

NSAIDs and incident Alzheimer’s disease. the Rotterdam study

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.089

21 January 2018

Identifiers

DOI

10.1515/BC.2010.089

1 reference

23 August 2017

1 reference