ERAD ubiquitin ligases: multifunctional tools for protein quality control and waste disposal in the endoplasmic reticulum (Q37784156)

23 August 2017

ERAD ubiquitin ligases: multifunctional tools for protein quality control and waste disposal in the endoplasmic reticulum (English)

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23 August 2017

endoplasmic reticulum

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Ernst Jarosch

3

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author name string

Martin Mehnert

series ordinal

1

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PubMed ID

20806269

23 August 2017

Thomas Sommer

series ordinal

2

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PubMed ID

20806269

23 August 2017

language of work or name

English

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publication date

30 August 2010

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23 August 2017

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23 August 2017

32

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23 August 2017

10

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23 August 2017

905-913

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Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes

23 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Quality control in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Quality Control and Protein Folding in the Secretory Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

N-glycan structures: recognition and processing in the ER.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

The ubiquitylation machinery of the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Glycoprotein folding, quality control and ER-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Defining the glycan destruction signal for endoplasmic reticulum-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

The role of MRH domain-containing lectins in ERAD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

The mammalian UPR boosts glycoprotein ERAD by suppressing the proteolytic downregulation of ER mannosidase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

ER-golgi traffic is a prerequisite for efficient ER degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Stimulation of ERAD of misfolded null Hong Kong alpha1-antitrypsin by Golgi alpha1,2-mannosidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Intrinsic conformational determinants signal protein misfolding to the Hrd1/Htm1 endoplasmic reticulum-associated degradation system

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Single, context-specific glycans can target misfolded glycoproteins for ER-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum-associated degradation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

RNF-121 is an endoplasmic reticulum-membrane E3 ubiquitin ligase involved in the regulation of beta-integrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

E3 ubiquitin ligase that recognizes sugar chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

ER stress differentially regulates the stabilities of ERAD ubiquitin ligases and their substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: cross-talk between E3s in the endoplasmic reticulum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Differential regulation of CFTRDeltaF508 degradation by ubiquitin ligases gp78 and Hrd1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Modularity of the Hrd1 ERAD complex underlies its diverse client range

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Usa1 functions as a scaffold of the HRD-ubiquitin ligase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

A membrane protein required for dislocation of misfolded proteins from the ER

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

The oligomeric state of Derlin-1 is modulated by endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

A genome-wide screen identifies Yos9p as essential for ER-associated degradation of glycoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Yos9p detects and targets misfolded glycoproteins for ER-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Yos9 protein is essential for degradation of misfolded glycoproteins and may function as lectin in ERAD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Usa1 protein facilitates substrate ubiquitylation through two separate domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Protein transport across the peroxisomal membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Cdc48 (p97): a "molecular gearbox" in the ubiquitin pathway?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Mechanisms of CD4 downregulation by the Nef and Vpu proteins of primate immunodeficiency viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Sec61p is required for ERAD-L: genetic dissection of the translocation and ERAD-L functions of Sec61P using novel derivatives of CPY.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Sec61p is part of the endoplasmic reticulum-associated degradation machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

X-ray structure of a protein-conducting channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Intracellular signaling by the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

The endoplasmic reticulum and the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

Derlin-1 facilitates the retro-translocation of cholera toxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

The E3 ubiquitin ligases Hrd1 and gp78 bind to and promote cholera toxin retro-translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000046

21 January 2018

Identifiers

DOI

10.1002/BIES.201000046

1 reference

23 August 2017

1 reference

PubMed ID

20806269