Vitamin D, disease and therapeutic opportunities (Q37814083)

23 August 2017

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title

Vitamin D, disease and therapeutic opportunities (English)

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23 August 2017

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2

Hector F DeLuca

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23 August 2017

Lori A Plum

1

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PubMed ID

21119732

23 August 2017

language of work or name

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1 December 2010

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Nature Reviews Drug Discovery

23 August 2017

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23 August 2017

9

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23 August 2017

941-955

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23 August 2017

12

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https://scigraph.springernature.com/pub.10.1038/nrd3318

23 August 2017

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cites work

Current understanding of the molecular actions of vitamin D.

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Basic and clinical concepts related to vitamin D metabolism and action (first of two parts).

31 March 2020

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Vitamin D: molecular mechanism of action

31 March 2020

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Mechanism of vitamin D receptor action

31 March 2020

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De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase

31 March 2020

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Site of 1,25(OH)2 vitamin D3 synthesis in the kidney

31 March 2020

1 reference

Osteoprotegerin and its ligand: a new paradigm for regulation of osteoclastogenesis and bone resorption.

31 March 2020

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Physiological regulation and disorders of phosphate metabolism--pivotal role of fibroblast growth factor 23

31 March 2020

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Endocrine functions of bone in mineral metabolism regulation.

31 March 2020

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Hydroxylase enzymes of the vitamin D pathway: expression, function, and regulation

31 March 2020

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Metabolites of 1 alpha, 25-dihydroxyvitamin D3 in rat bile

31 March 2020

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1α,25(OH)2-Vitamin D3–Mediated Rapid and Genomic Responses Are Dependent upon Critical Structure–Function Relationships for Both the Ligand and Receptor(s)

31 March 2020

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Nuclear and cytoplasmic binding components for vitamin D metabolites

31 March 2020

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Intestinal cytosol binders of 1,25-dihydroxyvitamin D and 25-hydroxyvitamin D

31 March 2020

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Cloning and expression of full-length cDNA encoding human vitamin D receptor

31 March 2020

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Isolation and expression of rat 1,25-dihydroxyvitamin D3 receptor cDNA

31 March 2020

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Rickets and Alopecia with Resistance to 1,25-Dihydroxyvitamin D: Two Different Clinical Courses with Two Different Cellular Defects*

31 March 2020

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Vitamin D and human health: lessons from vitamin D receptor null mice.

31 March 2020

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CYP27B1 null mice with LacZreporter gene display no 25-hydroxyvitamin D3-1alpha-hydroxylase promoter activity in the skin

31 March 2020

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31 March 2020

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Advancing age results in reduction of intestinal and bone 1,25-dihydroxyvitamin D receptor

31 March 2020

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Insulin-like growth factor-1 is associated with bone formation markers, PTH and bone mineral density in healthy premenopausal women

31 March 2020

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Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: effect of age and dietary calcium

31 March 2020

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Deficient Production of 1,25-Dihydroxyvitamin D in Elderly Osteoporotic Patients

31 March 2020

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Modulation of intestinal vitamin D receptor by ovariectomy, estrogen and growth hormone

31 March 2020

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Exogenous 1,25-dihydroxyvitamin D3 exerts a skeletal anabolic effect and improves mineral ion homeostasis in mice that are homozygous for both the 1alpha-hydroxylase and parathyroid hormone null alleles.

31 March 2020

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A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation

31 March 2020

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A new vitamin D analog, 2MD, restores trabecular and cortical bone mass and strength in ovariectomized rats with established osteopenia

31 March 2020

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2MD, a new anabolic agent for osteoporosis treatment.

31 March 2020

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The vitamin D analogue 2MD increases bone turnover but not BMD in postmenopausal women with osteopenia: results of a 1-year phase 2 double-blind, placebo-controlled, randomized clinical trial

31 March 2020

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D-hormone derivatives for the treatment of osteoporosis: from alfacalcidol to eldecalcitol

31 March 2020

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Active vitamin D and its analogs as drugs for the treatment of osteoporosis: advantages and problems

31 March 2020

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Treatment of postmenopausal osteoporosis with calcitriol or calcium

31 March 2020

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ED-71, a new active vitamin D3, increases bone mineral density regardless of serum 25(OH)D levels in osteoporotic subjects.

31 March 2020

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The effect of vitamin D2 and vitamin D3 on intestinal calcium absorption in Nigerian children with rickets.

31 March 2020

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The journey from vitamin D-resistant rickets to the regulation of renal phosphate transport

31 March 2020

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Hypophosphatemic rickets and osteomalacia

31 March 2020

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Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodystrophy

31 March 2020

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The biochemical basis of renal osteodystrophy and post-menopausal osteoporosis: a view from the vitamin D system

31 March 2020

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Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid

31 March 2020

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Cytoplasmic and nuclear binding components for 1alpha25-dihydroxyvitamin D3 in chick parathyroid glands

31 March 2020

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Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat.

31 March 2020

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Drug insight: vitamin D analogs in the treatment of secondary hyperparathyroidism in patients with chronic kidney disease

31 March 2020

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Differential effects of 19-nor-1,25-dihydroxyvitamin D(2) and 1,25-dihydroxyvitamin D(3) on intestinal calcium and phosphate transport

31 March 2020

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1 alpha-Hydroxyvitamin D2 is less toxic than 1 alpha-hydroxyvitamin D3 in the rat.

31 March 2020

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Vitamin D analogs: new therapeutic agents for secondary hyperparathyroidism

31 March 2020

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Possible renoprotection by vitamin D in chronic renal disease: beyond mineral metabolism

31 March 2020

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Is calcitriol life-protective for patients with chronic kidney disease?

31 March 2020

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Oral paricalcitol in the treatment of patients with CKD and proteinuria: a randomized trial.

31 March 2020

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Oral calcitriol for the treatment of persistent proteinuria in immunoglobulin A nephropathy: an uncontrolled trial

31 March 2020

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Paricalcitol reduces albuminuria and inflammation in chronic kidney disease: a randomized double-blind pilot trial

31 March 2020

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Vascular calcification: the killer of patients with chronic kidney disease.

31 March 2020

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Myocardial effects of VDR activators in renal failure

31 March 2020

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Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice

31 March 2020

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25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study

31 March 2020

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25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services

31 March 2020

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Role of vitamin D in blood pressure homeostasis

31 March 2020

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Characterization of the vitamin D endocrine system in human sebocytes in vitro

31 March 2020

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Biologic effects of topical calcipotriol (MC 903) treatment in psoriatic skin

31 March 2020

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Characterization of a receptor-like protein for 1,25-dihydroxyvitamin D3 in rat skin

31 March 2020

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Regulation of Terminal Differentiation of Cultured Mouse Epidermal Cells by lα,25-Dihydroxyvitamin D3*

31 March 2020

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Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3

31 March 2020

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1,25-Dihydroxyvitamin D3 and the skin: a unique application for the treatment of psoriasis.

31 March 2020

1 reference

Calcipotriol: a new drug for topical psoriasis treatment

31 March 2020

1 reference

Topical maxacalcitol for the treatment of psoriasis vulgaris: a placebo-controlled, double-blind, dose-finding study with active comparator

31 March 2020

1 reference

31 March 2020

Pharmacotherapy of acne

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Identification of a unique subset of 2-methylene-19-nor analogs of vitamin D with comedolytic activity in the rhino mouse

31 March 2020

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SPECIFIC HIGH-AFFINITY RECEPTORS FOR 1,25-DIHYDROXYVITAMIN D3IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS: PRESENCE IN MONOCYTES AND INDUCTION IN T LYMPHOCYTES FOLLOWING ACTIVATION

31 March 2020

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1,25-Dihydroxyvitamin D3Receptors in Human Leukocytes

31 March 2020

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Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system

31 March 2020

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Control of autoimmune diseases by the vitamin D endocrine system

31 March 2020

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1 alpha, 25-Dihydroxyvitamin D3 and 19-nor-1 alpha, 25-dihydroxyvitamin D2 suppress immunoglobulin production and thymic lymphocyte proliferation in vivo

31 March 2020

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Diet and the geographical distribution of multiple sclerosis.

31 March 2020

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1,25-dihydroxyvitamin D3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis

31 March 2020

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Prevention of murine experimental allergic encephalomyelitis: cooperative effects of cyclosporine and 1 alpha, 25-(OH)2D3

31 March 2020

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1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis

31 March 2020

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Hypercalcemia produced by parathyroid hormone suppresses experimental autoimmune encephalomyelitis in female but not male mice.

31 March 2020

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Dietary calcium is a major factor in 1,25-dihydroxycholecalciferol suppression of experimental autoimmune encephalomyelitis in mice

31 March 2020

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UV radiation suppresses experimental autoimmune encephalomyelitis independent of vitamin D production.

31 March 2020

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A pilot study of oral calcitriol (1,25-dihydroxyvitamin D3) for relapsing-remitting multiple sclerosis

31 March 2020

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Vitamin D and autoimmune diabetes

31 March 2020

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Oral administration of 1,25-dihydroxyvitamin D3 completely protects NOD mice from insulin-dependent diabetes mellitus

31 March 2020

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Vitamin D in type 1 diabetes prevention

31 March 2020

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Calcium and 1 alpha,25-dihydroxyvitamin D3 target the TNF-alpha pathway to suppress experimental inflammatory bowel disease

31 March 2020

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Efficacy of a potent and safe vitamin D receptor agonist for the treatment of inflammatory bowel disease

31 March 2020

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Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease

31 March 2020

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Vitamin D and autoimmune rheumatic diseases

31 March 2020

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1,25-Dihydroxycholecalciferol inhibits the progression of arthritis in murine models of human arthritis

31 March 2020

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Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system

31 March 2020

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Target cells for 1,25 dihydroxyvitamin D3 in the pancreas

31 March 2020

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1,25-dihydroxyvitamin D3 and malignant melanoma: the presence of receptors and inhibition of cell growth in culture

31 March 2020

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Prevention of colorectal cancer with vitamin D.

31 March 2020

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The epidemiology of vitamin D and cancer incidence and mortality: a review (United States).

31 March 2020

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Vitamin D and intervention trials in prostate cancer: from theory to therapy

31 March 2020

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Vitamin D and breast cancer

31 March 2020

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Ecological studies of ultraviolet B, vitamin D and cancer since 2000.

31 March 2020

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The role of vitamin D in cancer prevention

31 March 2020

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Promise of vitamin D analogues in the treatment of hyperproliferative conditions

31 March 2020

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Vitamin D and cancer: an update of in vitro and in vivo data.

31 March 2020

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Vitamin D receptor (VDR) ablation alters carcinogen-induced tumorigenesis in mammary gland, epidermis and lymphoid tissues

31 March 2020

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Vitamin D signalling pathways in cancer: potential for anticancer therapeutics

31 March 2020

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Docetaxel-based combination therapy for castration-resistant prostate cancer

31 March 2020

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Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial

31 March 2020

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Calcium plus vitamin D supplementation and the risk of colorectal cancer

31 March 2020

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Vitamin D for the prevention and treatment of pancreatic cancer

31 March 2020

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Predicted vitamin D status and pancreatic cancer risk in two prospective cohort studies

31 March 2020

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Scientific documentation of the relationship of vitamin D deficiency and the development of cancer

31 March 2020

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Dietary vitamin D and risk of non-Hodgkin lymphoma: the multiethnic cohort

31 March 2020

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A phase II trial of the vitamin D analogue Seocalcitol (EB1089) in patients with inoperable pancreatic cancer

31 March 2020

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Alfacalcidol as a modulator of growth of low grade non-Hodgkin's lymphomas

31 March 2020

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Alfacalcidol is a nontoxic, effective treatment of follicular small-cleaved cell lymphoma

31 March 2020

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A phase II study of the vitamin D analogue Seocalcitol in patients with inoperable hepatocellular carcinoma

31 March 2020

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Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardization

31 March 2020

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Falsely high serum free triiodothyronine and free thyroxine concentrations attributable to anti-diiodothyronine and anti-triiodothyronine antibodies

31 March 2020

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Of mice and humans: are they the same?--Implications in cancer translational research

31 March 2020

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The candidate oncogene CYP24A1: A potential biomarker for colorectal tumorigenesis

31 March 2020

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Identification of a highly specific and versatile vitamin D receptor antibody

31 March 2020

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Vitamin D and The Magic Mountain: the anti-infectious role of the vitamin

31 March 2020

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Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression

31 March 2020

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A randomized controlled trial of vitamin D3 supplementation for the prevention of symptomatic upper respiratory tract infections

31 March 2020

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Vitamin d deficiency and tuberculosis progression

31 March 2020

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Pharmacokinetics of vitamin D toxicity

31 March 2020

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Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety

31 March 2020

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Plasma concentrations of vitamin D3 and its metabolites in the rat as influenced by vitamin D3 or 25-hydroxyvitamin D3 intakes

31 March 2020

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1,25-Dihydroxyvitamin D is not responsible for toxicity caused by vitamin D or 25-hydroxyvitamin D

31 March 2020

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Intestinal 1,25-dihydroxyvitamin D3 binding protein: specificity of binding

31 March 2020

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Hypercalcemia in an anephric patient with sarcoidosis: evidence for extrarenal generation of 1,25-dihydroxyvitamin D.

31 March 2020

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Rare causes of calcitriol-mediated hypercalcemia: a case report and literature review

31 March 2020

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Hypercalcemia associated with increased serum calcitriol levels in three patients with lymphoma

31 March 2020

1 reference

26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D3: A highly potent, long-lasting analog of 1,25-dihydroxyvitamin D3

31 March 2020

1 reference

Highly antiproliferative, low-calcemic, side-chain amide and hydroxamate analogs of the hormone 1alpha,25-dihydroxyvitamin D3

31 March 2020

1 reference

'Novel alkyl side chain sulfone 1alpha,25-dihydroxyvitamin D3 analogs: a comparison of in vitro antiproliferative activities and in vivo calcemic activities'.

31 March 2020

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Biologically active noncalcemic analogs of 1alpha,25-dihydroxyvitamin D with an abbreviated side chain containing no hydroxyl

31 March 2020

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Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands

31 March 2020

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Molecular structure of the rat vitamin D receptor ligand binding domain complexed with 2-carbon-substituted vitamin D3 hormone analogues and a LXXLL-containing coactivator peptide

31 March 2020

1 reference

New analogs of 2-methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 with conformationally restricted side chains: evaluation of biological activity and structural determination of VDR-bound conformations

31 March 2020

1 reference

Topical calcipotriol treatment in advanced breast cancer

31 March 2020

1 reference

A phase I study of the vitamin D analogue EB 1089 in patients with advanced breast and colorectal cancer

31 March 2020

1 reference

Phase IB study of 25-hydroxyvitamin D(3) treatment to diminish suppressor cells in head and neck cancer patients

31 March 2020

1 reference

Treatment of acute myeloid leukemia in the elderly with low-dose cytarabine, hydroxyurea, and calcitriol

31 March 2020

1 reference

Pharmacokinetics and safety of ILX23-7553, a non-calcemic-vitamin D3 analogue, in a phase I study of patients with advanced malignancies.

31 March 2020

1 reference

A phase I pharmacokinetic and pharmacodynamic study of intravenous calcitriol in combination with oral gefitinib in patients with advanced solid tumors.

31 March 2020

1 reference

A phase I and pharmacokinetics study of intravenous calcitriol in combination with oral dexamethasone and gefitinib in patients with advanced solid tumors

31 March 2020

1 reference

Phase II trial of oral 1,25-dihydroxyvitamin D (calcitriol) in hormone refractory prostate cancer

31 March 2020

1 reference

High-dose weekly oral calcitriol in patients with a rising PSA after prostatectomy or radiation for prostate carcinoma

31 March 2020

1 reference

Weekly high-dose calcitriol and docetaxel in metastatic androgen-independent prostate cancer

31 March 2020

1 reference

High-dose calcitriol and carboplatin in metastatic androgen-independent prostate cancer

31 March 2020

1 reference

Phase I/II study of 19-nor-1alpha-25-dihydroxyvitamin D2 (paricalcitol) in advanced, androgen-insensitive prostate cancer

31 March 2020

1 reference

High dose pulse calcitriol, docetaxel and estramustine for androgen independent prostate cancer: a phase I/II study

31 March 2020

1 reference

Phase II trial of high-dose, intermittent calcitriol (1,25 dihydroxyvitamin D3) and dexamethasone in androgen-independent prostate cancer.

31 March 2020

1 reference

Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators

31 March 2020

1 reference

Expression of vitamin D receptor and 25-hydroxyvitamin D3-1{alpha}-hydroxylase in normal and malignant human colon

31 March 2020

1 reference

Phase I trial of 1alpha-hydroxyvitamin d(2) in patients with hormone refractory prostate cancer

31 March 2020

1 reference

12 December 2020

Calcium plus vitamin D supplementation and the risk of breast cancer

1 reference

12 December 2020

Overview of the proceedings from Experimental Biology 2004 symposium: vitamin D insufficiency: a significant risk factor in chronic diseases and potential disease-specific biomarkers of vitamin D sufficiency

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12 December 2020

Role of vitamin D in pulmonary tuberculosis

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12 December 2020

Disease modifying and immunomodulatory effects of high dose 1 alpha (OH) D3 in rheumatoid arthritis patients

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12 December 2020

Treatment of early recurrent prostate cancer with 1,25-dihydroxyvitamin D3 (calcitriol)

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12 December 2020

Vitamin D-dependent rickets type I and type II.

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12 December 2020

Vitamin D: the vitamin and the hormone.

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12 December 2020

Phase II study of 1alpha-hydroxyvitamin D(2) in the treatment of advanced androgen-independent prostate cancer

1 reference

12 December 2020

Geographic patterns of childhood insulin-dependent diabetes mellitus. Diabetes Epidemiology Research International Group

1 reference

12 December 2020

Clinical features of hereditary resistance to 1,25-dihydroxyvitamin D (hereditary hypocalcemic vitamin D resistant rickets type II).

1 reference

12 December 2020

How accurate are assays for 25-hydroxyvitamin D? Data from the international vitamin D external quality assessment scheme

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12 December 2020

Identifiers

DOI

10.1038/NRD3318

1 reference

23 August 2017

1 reference

PubMed ID

21119732