RNA interference in the clinic: challenges and future directions (Q37821230)

23 August 2017

1 reference

title

RNA interference in the clinic: challenges and future directions (English)

1 reference

23 August 2017

1 reference

2

George A Calin

1 reference

23 August 2017

5

Anil K Sood

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23 August 2017

Chad V Pecot

1

1 reference

23 August 2017

Robert L Coleman

series ordinal

3

1 reference

23 August 2017

Gabriel Lopez-Berestein

series ordinal

4

1 reference

23 August 2017

language of work or name

English

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publication date

16 December 2010

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23 August 2017

Nature Reviews Cancer

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23 August 2017

11

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23 August 2017

59-67

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23 August 2017

1

1 reference

https://scigraph.springernature.com/pub.10.1038/nrc2966

23 August 2017

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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

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In vivo imaging of RNA interference

6 September 2017

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Lipid-like materials for low-dose, in vivo gene silencing

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6 September 2017

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Structural insights into RNA interference

6 September 2017

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Enabling individualized therapy through nanotechnology

6 September 2017

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Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

6 September 2017

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Regulating the regulators: posttranslational modifications of RNA silencing factors

6 September 2017

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Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs

6 September 2017

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siRNA and innate immunity

6 September 2017

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Dual targeting of EphA2 and FAK in ovarian carcinoma

6 September 2017

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Dicer, Drosha, and outcomes in patients with ovarian cancer

6 September 2017

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3-D tissue culture systems for the evaluation and optimization of nanoparticle-based drug carriers

6 September 2017

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FERM control of FAK function: implications for cancer therapy.

6 September 2017

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Factors affecting the clearance and biodistribution of polymeric nanoparticles.

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Maintaining the silence: reflections on long-term RNAi

6 September 2017

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Coexpression of Argonaute-2 enhances RNA interference toward perfect match binding sites

6 September 2017

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Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution

6 September 2017

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Survival of cancer cells is maintained by EGFR independent of its kinase activity

6 September 2017

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A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

6 September 2017

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Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

6 September 2017

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The receptor-mediated endocytosis of nonspherical particles

6 September 2017

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Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC

6 September 2017

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6 September 2017

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Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA.

6 September 2017

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Strategies for silencing human disease using RNA interference

6 September 2017

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Circulating (cell-free) nucleic acids--a promising, non-invasive tool for early detection of several human diseases

6 September 2017

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Common genetic variants account for differences in gene expression among ethnic groups

6 September 2017

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Illuminating the silence: understanding the structure and function of small RNAs

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

RNAi therapeutics: a potential new class of pharmaceutical drugs

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Mathematical modeling of cancer progression and response to chemotherapy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

The widespread impact of mammalian MicroRNAs on mRNA repression and evolution

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Toxicogenomics of cationic lipid-based vectors for gene therapy: impact of microarray technology.

6 September 2017

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"New"-clear functions of PDK1: beyond a master kinase in the cytosol?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

MicroRNA biogenesis: coordinated cropping and dicing

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Cationic lipids enhance siRNA-mediated interferon response in mice.

6 September 2017

1 reference

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Unlocking the potential of the human genome with RNA interference

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Mechanisms of gene silencing by double-stranded RNA

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Argonaute2 is the catalytic engine of mammalian RNAi

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

6 September 2017

1 reference

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Kinetic analysis of the RNAi enzyme complex

6 September 2017

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Neutrophil extracellular traps kill bacteria

6 September 2017

1 reference

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Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Expression profiling reveals off-target gene regulation by RNAi

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

The dawning era of polymer therapeutics

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Long-circulating and target-specific nanoparticles: theory to practice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Semiconductor nanocrystals as fluorescent biological labels

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Nanoparticle-aptamer conjugates for cancer cell targeting and detection.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

RNAi and iTRAQ reagents united: targeted quantitation of siRNA-mediated protein silencing in human cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Quantum-dot based nanoparticles for targeted silencing of HER2/neu gene via RNA interference

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Intravenous delivery of anti-RhoA small interfering RNA loaded in nanoparticles of chitosan in mice: safety and efficacy in xenografted aggressive breast cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Chemically modified short interfering hybrids (siHYBRIDS): nanoimmunoliposome delivery in vitro and in vivo for RNAi of HER-2.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Comparative evaluation of target-specific GFP gene silencing efficiencies for antisense ODN, synthetic siRNA, and siRNA plasmid complexed with PEI-PEG-FOL conjugate

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Cellular pharmacology of P-ethoxy antisense oligonucleotides targeted to Bcl-2 in a follicular lymphoma cell line

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Telomerase RNA as a detection marker in the serum of breast cancer patients

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Extracellular barriers to in Vivo PEI and PEGylated PEI polyplex-mediated gene delivery to the liver

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

The mathematical engines of nanomedicine.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Design maps for nanoparticles targeting the diseased microvasculature.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Chemically modified siRNA prolonged RNA interference in renal disease

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Mechanisms and optimization of in vivo delivery of lipophilic siRNAs.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

The effective dispersion of nanovectors within the tumor microvasculature.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Dose-finding based on efficacy-toxicity trade-offs

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Oxygen radical-mediated pulmonary toxicity induced by some cationic liposomes

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199132

Breaking down the barriers: siRNA delivery and endosome escape

1 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNRC2966

Phagocytosis Independent Extracellular Nanoparticle Clearance by Human Immune Cells

31 March 2020

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNRC2966

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

31 March 2020

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNRC2966

Microvascular architecture of experimental colon tumors in the rat

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21160526

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Detection of tumor messenger RNA in the serum of patients with malignant melanoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21160526

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRC2966

1 reference

23 August 2017

1 reference

23 August 2017

1 reference