Illuminating the silence: understanding the structure and function of small RNAs (Q29622905)

Europe PubMed Central

title

Illuminating the silence: understanding the structure and function of small RNAs (English)

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30 April 2017

author name string

Rana TM

series ordinal

1

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17183358

30 April 2017

language of work or name

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30 April 2017

publication date

January 2007

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Nature Reviews Molecular Cell Biology

30 April 2017

published in

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volume

8

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page(s)

23-36

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issue

1

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Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation

30 April 2017

cites work

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

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Role for a bidentate ribonuclease in the initiation step of RNA interference

31 March 2020

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Argonaute2, a link between genetic and biochemical analyses of RNAi

31 March 2020

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Targeted mRNA degradation by double-stranded RNA in vitro

31 March 2020

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RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

31 March 2020

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Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

31 March 2020

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

31 March 2020

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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

31 March 2020

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siRNAs can function as miRNAs

31 March 2020

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MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

31 March 2020

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Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation

31 March 2020

1 reference

The role of RNA interference in heterochromatic silencing

31 March 2020

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Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA

31 March 2020

1 reference

Unlocking the potential of the human genome with RNA interference

31 March 2020

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Mechanisms of gene silencing by double-stranded RNA

31 March 2020

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RNase III enzymes and the initiation of gene silencing

31 March 2020

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Human RISC couples microRNA biogenesis and posttranscriptional gene silencing

31 March 2020

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Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.

31 March 2020

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Synthetic shRNAs as potent RNAi triggers.

31 March 2020

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MicroRNA function in animal development

31 March 2020

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The functions of animal microRNAs

31 March 2020

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MicroRNAs: genomics, biogenesis, mechanism, and function

31 March 2020

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31 March 2020

RNA silencing in plants

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Small RNAs and Arabidopsis. A fast forward look

31 March 2020

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Identification of novel genes coding for small expressed RNAs

31 March 2020

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An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans

31 March 2020

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miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

31 March 2020

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MicroRNA biogenesis: coordinated cropping and dicing

31 March 2020

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The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis

31 March 2020

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The Microprocessor complex mediates the genesis of microRNAs

31 March 2020

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Processing of primary microRNAs by the Microprocessor complex

31 March 2020

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The Drosha-DGCR8 complex in primary microRNA processing

31 March 2020

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Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex

31 March 2020

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Nuclear export of microRNA precursors

31 March 2020

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Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs

31 March 2020

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Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

31 March 2020

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Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54

31 March 2020

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Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies

31 March 2020

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Inhibition of translational initiation by Let-7 MicroRNA in human cells

31 March 2020

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MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

31 March 2020

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Control of translation and mRNA degradation by miRNAs and siRNAs

31 March 2020

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Stress granules and processing bodies are dynamically linked sites of mRNP remodeling

31 March 2020

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RNAi in human cells: basic structural and functional features of small interfering RNA.

31 March 2020

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siRNA function in RNAi: a chemical modification analysis

31 March 2020

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Kinetic analysis of the RNAi enzyme complex

31 March 2020

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Tolerance for mutations and chemical modifications in a siRNA.

31 March 2020

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Major groove opening at the HIV-1 Tat binding site of TAR RNA evidenced by a rhodium probe

31 March 2020

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Major groove accessibility of RNA

31 March 2020

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31 March 2020

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MicroRNA-directed cleavage of HOXB8 mRNA

31 March 2020

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A microRNA in a multiple-turnover RNAi enzyme complex

31 March 2020

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Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells

31 March 2020

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Revealing the world of RNA interference

31 March 2020

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Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase.

31 March 2020

1 reference

An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus

31 March 2020

1 reference

RNAi as random degradative PCR: siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs.

31 March 2020

1 reference

Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance

31 March 2020

1 reference

On the role of RNA amplification in dsRNA-triggered gene silencing

31 March 2020

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A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst

31 March 2020

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Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

31 March 2020

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Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

31 March 2020

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Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi in Drosophila

31 March 2020

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Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

31 March 2020

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Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex

31 March 2020

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Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

31 March 2020

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Expression profiling reveals off-target gene regulation by RNAi

31 March 2020

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RNAi-mediated gene silencing in non-human primates.

31 March 2020

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Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

31 March 2020

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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

31 March 2020

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Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

31 March 2020

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RNAi: the nuts and bolts of the RISC machine

31 March 2020

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Ribo-gnome: the big world of small RNAs

31 March 2020

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Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

31 March 2020

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Argonaute2 is the catalytic engine of mammalian RNAi

31 March 2020

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Crystal structure of Argonaute and its implications for RISC slicer activity

31 March 2020

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Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

31 March 2020

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Asymmetry in the assembly of the RNAi enzyme complex

31 March 2020

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Functional siRNAs and miRNAs Exhibit Strand Bias

31 March 2020

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Cleavage of the siRNA passenger strand during RISC assembly in human cells

31 March 2020

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Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

31 March 2020

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Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation

31 March 2020

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An algorithm for selection of functional siRNA sequences.

31 March 2020

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Enhancement of RNAi activity by improved siRNA duplexes.

31 March 2020

1 reference

siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference

31 March 2020

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Rational siRNA design for RNA interference

31 March 2020

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Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference

31 March 2020

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Filtering of ineffective siRNAs and improved siRNA design tool.

31 March 2020

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RISC is a 5' phosphomonoester-producing RNA endonuclease

31 March 2020

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Assembly and function of RNA silencing complexes

31 March 2020

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Target accessibility dictates the potency of human RISC

31 March 2020

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Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing

31 March 2020

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Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9/CyclinT1).

31 March 2020

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TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

31 March 2020

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Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein

31 March 2020

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TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing

31 March 2020

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31 March 2020

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Specificity of microRNA target selection in translational repression

31 March 2020

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Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

31 March 2020

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Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways

31 March 2020

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The RNA-induced silencing complex is a Mg2+-dependent endonuclease.

31 March 2020

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Local RNA target structure influences siRNA efficacy: systematic analysis of intentionally designed binding regions

31 March 2020

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Local RNA target structure influences siRNA efficacy: a systematic global analysis

31 March 2020

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Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA.

31 March 2020

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Initiation of translation in prokaryotes and eukaryotes

31 March 2020

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Silencing of microRNAs in vivo with 'antagomirs'

31 March 2020

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The silent revolution: RNA interference as basic biology, research tool, and therapeutic

31 March 2020

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An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

31 March 2020

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Endogenous trans-acting siRNAs regulate the accumulation of Arabidopsis mRNAs

31 March 2020

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SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis

31 March 2020

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Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi

31 March 2020

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Small RNAs correspond to centromere heterochromatic repeats

31 March 2020

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Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline

31 March 2020

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Small RNAs in genome rearrangement in Tetrahymena.

31 March 2020

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A novel class of small RNAs bind to MILI protein in mouse testes

31 March 2020

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A germline-specific class of small RNAs binds mammalian Piwi proteins

31 March 2020

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A novel class of small RNAs in mouse spermatogenic cells

31 March 2020

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Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes

31 March 2020

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Characterization of the piRNA Complex from Rat Testes

31 March 2020

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Two mouse piwi-related genes: miwi and mili

31 March 2020

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Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways

31 March 2020

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Single processing center models for human Dicer and bacterial RNase III

31 March 2020

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Slicer function of Drosophila Argonautes and its involvement in RISC formation

31 March 2020

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Processing of pre-microRNAs by the Dicer-1-Loquacious complex in Drosophila cells

31 March 2020

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Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila

31 March 2020

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The role of PACT in the RNA silencing pathway

31 March 2020

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Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity

31 March 2020

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Maintaining inhibition: siRNA double expression vectors against coxsackieviral RNAs

31 March 2020

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Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor

31 March 2020

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Positional effect of chemical modifications on short interference RNA activity in mammalian cells

31 March 2020

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RNA interference in mammalian cells by chemically-modified RNA.

31 March 2020

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Small interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity

31 March 2020

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Purified Argonaute2 and an siRNA form recombinant human RISC

31 March 2020

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Investigating the structure of human RNase H1 by site-directed mutagenesis

31 March 2020

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17183358

31 March 2020

Identifiers

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1073138

1053741720

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1073138

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Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17183358

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30 April 2017

Consolidated OpenCitations Corpus – April 2017