Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs (Q24299641)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0090624

mRNA destabilization-mediated gene silencing by siRNA

2 references

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0090625

Argonaute RISC component 4

1 reference

Argonaute RISC component 1

1 reference

Argonaute RISC catalytic component 3

1 reference

Argonaute RISC catalytic component 2

1 reference

author

Thomas Tuschl

6

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Markus Landthaler

2

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author name string

Gunter Meister

1

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Agnieszka Patkaniowska

3

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Yair Dorsett

4

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Grace Teng

The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation

5

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language of work or name

English

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publication date

23 July 2004

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published in

Molecular Cell

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volume

15

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page(s)

185-97

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issue

2

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cites work

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CARPEL FACTORY, a Dicer homolog, and HEN1, a novel protein, act in microRNA metabolism in Arabidopsis thaliana

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PPW-1, a PAZ/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of C. elegans.

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miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis

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An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

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The nuclear RNase III Drosha initiates microRNA processing

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Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain

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Spatially restricted microRNA directs leaf polarity through ARGONAUTE1.

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The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes

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RNase III enzymes and the initiation of gene silencing

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Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain

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Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer

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ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos

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AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals

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Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA

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RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans

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Suppression of gene silencing: a general strategy used by diverse DNA and RNA viruses of plants

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Two classes of short interfering RNA in RNA silencing

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RNA interference is mediated by 21- and 22-nucleotide RNAs

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Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

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Short RNAs can identify new candidate transposable element families in Arabidopsis

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Fertile hypomorphic ARGONAUTE (ago1) mutants impaired in post-transcriptional gene silencing and virus resistance

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Argonaute2, a link between genetic and biochemical analyses of RNAi

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Numerous microRNPs in neuronal cells containing novel microRNAs

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Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing

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Sequence-specific inhibition of small RNA function

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Genetic and functional diversification of small RNA pathways in plants

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Evidence for a piwi-dependent RNA silencing of the gypsy endogenous retrovirus by the Drosophila melanogaster flamenco gene

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