Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives. (Q37825614)

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19 January 2020

review article

3 references

20 January 2021

8 February 2021

Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives (English)

1 reference

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19 January 2020

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3 April 2019

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2 October 2019

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11 December 2019

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19 December 2019

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20 January 2021

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8 February 2021

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21199331%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Alan E Bilsland

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1

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19 January 2020

Nicol Keith

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3

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19 January 2020

author name string

W Nicol Keith

series ordinal

3

1 reference

23 August 2017

1 February 2011

7 references

3 April 2019

2 October 2019

11 December 2019

19 December 2019

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19 January 2020

20 January 2021

8 February 2021

Journal of Cellular and Molecular Medicine

7 references

3 April 2019

2 October 2019

11 December 2019

19 December 2019

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15

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19 January 2020

issue

2

1 reference

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19 January 2020

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179-186

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TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo

19 January 2020

cites work

1 reference

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6 September 2017

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The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells

6 September 2017

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Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors

6 September 2017

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Dynamic telomerase gene suppression via network effects of GSK3 inhibition

6 September 2017

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Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

6 September 2017

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Targeting the telosome: therapeutic implications

6 September 2017

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TRF2 promotes, remodels and protects telomeric Holliday junctions

6 September 2017

1 reference

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Fragment-based identification of druggable 'hot spots' of proteins using Fourier domain correlation techniques

6 September 2017

1 reference

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The effect of the TRF2 N-terminal and TRFH regions on telomeric G-quadruplex structures

6 September 2017

1 reference

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How shelterin protects mammalian telomeres

6 September 2017

1 reference

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Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes

6 September 2017

1 reference

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Telomerase and cancer therapeutics

6 September 2017

1 reference

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A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins

6 September 2017

1 reference

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Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis

6 September 2017

1 reference

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Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect

6 September 2017

1 reference

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Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

6 September 2017

1 reference

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The POT1-TPP1 telomere complex is a telomerase processivity factor

6 September 2017

1 reference

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TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase

6 September 2017

1 reference

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A topological mechanism for TRF2-enhanced strand invasion

6 September 2017

1 reference

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The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells

6 September 2017

1 reference

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Antisense oligonucleotide-mediated inhibition of hTERT, but not hTERC, induces rapid cell growth decline and apoptosis in the absence of telomere shortening in human prostate cancer cells.

6 September 2017

1 reference

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Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics.

6 September 2017

1 reference

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POT1 as a terminal transducer of TRF1 telomere length control

6 September 2017

1 reference

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Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate.

6 September 2017

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Alternative lengthening of telomeres in mammalian cells

6 September 2017

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A highly selective telomerase inhibitor limiting human cancer cell proliferation

6 September 2017

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A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation

6 September 2017

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Control of human telomere length by TRF1 and TRF2

6 September 2017

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Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability

6 September 2017

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Synthesis of a potent G-quadruplex-binding macrocyclic heptaoxazole

6 September 2017

1 reference

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Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance

14 September 2017

1 reference

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Antitumor polycyclic acridines. 20. Search for DNA quadruplex binding selectivity in a series of 8,13-dimethylquino[4,3,2-kl]acridinium salts: telomere-targeted agents

14 September 2017

1 reference

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Mechanism of acridine-based telomerase inhibition and telomere shortening

14 September 2017

1 reference

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TRF2 promotes multidrug resistance in gastric cancer cells

14 September 2017

1 reference

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Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells

14 September 2017

1 reference

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Antitumor polycyclic acridines. 17. Synthesis and pharmaceutical profiles of pentacyclic acridinium salts designed to destabilize telomeric integrity

14 September 2017

1 reference

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Telomerase inhibition, telomere shortening, cell growth suppression and induction of apoptosis by telomestatin in childhood neuroblastoma cells

14 September 2017

1 reference

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Pharmacodynamics of the G-quadruplex-stabilizing telomerase inhibitor 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4) in vitro: activity in human tumor cells correlates with telomere length and can be enhanced, or an

14 September 2017

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The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.

14 September 2017

1 reference

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A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells

14 September 2017

1 reference

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A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity

14 September 2017

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Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes.

28 September 2017

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Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability

28 September 2017

1 reference

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A negative regulator of telomere-length protein trf1 is associated with interstitial (TTAGGG)n blocks in immortal Chinese hamster ovary cells

28 September 2017

1 reference

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Plk1 phosphorylation of TRF1 is essential for its binding to telomeres

28 September 2017

1 reference

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Upregulation and CpG island hypomethylation of the TRF2 gene in human gastric cancer

23 June 2018

1 reference

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G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors.

1 September 2018

1 reference

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ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells

1 September 2018

1 reference

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Novel polyoxazole-based cyclopeptides from Streptomyces sp. Total synthesis of the cyclopeptide YM-216391 and synthetic studies towards telomestatin

1 September 2018

1 reference

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Decomposition of the telomere-targeting agent BRACO19 in physiological media results in products with decreased inhibitory potential

1 September 2018

1 reference

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G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells

1 September 2018

1 reference

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Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA.

1 September 2018

1 reference

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Trisubstituted acridine derivatives as potent and selective telomerase inhibitors.

1 September 2018

1 reference

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Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways

1 September 2018

1 reference

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Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex

1 September 2018

1 reference

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Targeting telomeres and telomerase

1 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2010.01253.X

Total synthesis of (R)-telomestatin

21 January 2018

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12 December 2020

Telomerase inhibition with a novel G-quadruplex-interactive agent, telomestatin: in vitro and in vivo studies in acute leukemia

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12 December 2020

Low- to high-throughput analysis of telomerase modulators with Telospot

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12 December 2020

Inhibition of human telomerase by a G-quadruplex-interactive compound

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12 December 2020

10.1111/J.1582-4934.2010.01253.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21199331%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21199331%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

21199331

1 reference