Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases. (Q37833502)

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21 January 2020

review article

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title

Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases (English)

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21 January 2020

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2

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21 January 2020

author name string

E Colombo

series ordinal

1

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21 January 2020

P G Pelicci

series ordinal

3

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21 January 2020

language of work or name

English

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publication date

31 January 2011

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21 January 2020

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21 January 2020

volume

30

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21 January 2020

issue

23

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21 January 2020

page(s)

2595-2609

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https://scigraph.springernature.com/pub.10.1038/onc.2010.646

21 January 2020

exact match

0 references

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NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors.

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Involvement of nPKC-MAPK pathway in the decrease of nucleophosmin/B23 during megakaryocytic differentiation of human myelogenous leukemia K562 cells.

31 March 2020

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Identification of nucleophosmin as an NF-kappaB co-activator for the induction of the human SOD2 gene

31 March 2020

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Nucleophosmin blocks mitochondrial localization of p53 and apoptosis

31 March 2020

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

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Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML.

31 March 2020

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31 March 2020

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NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia.

31 March 2020

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31 March 2020

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31 March 2020

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CRM1 is responsible for intracellular transport mediated by the nuclear export signal

31 March 2020

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B23 regulates GADD45a nuclear translocation and contributes to GADD45a-induced cell cycle G2-M arrest

31 March 2020

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Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin

31 March 2020

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Role of nucleophosmin in embryonic development and tumorigenesis

31 March 2020

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Structural Consequences of Nucleophosmin Mutations in Acute Myeloid Leukemia

31 March 2020

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A monoclonal antibody against mutated nucleophosmin 1 for the molecular diagnosis of acute myeloid leukemias

31 March 2020

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Nucleophosmin interacts with HEXIM1 and regulates RNA polymerase II transcription

31 March 2020

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Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells

31 March 2020

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AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.646

The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.646

The ribonuclease activity of nucleolar protein B23.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Mapping the functional domains of nucleolar protein B23

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.646

Over-expression of nucleophosmin/B23 decreases the susceptibility of human leukemia HL-60 cells to retinoic acid-induced differentiation and apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

RNA aptamers interfering with nucleophosmin oligomerization induce apoptosis of cancer cells.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.646

MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia

31 March 2020

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The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly

31 March 2020

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A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells

31 March 2020

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Nuclear transport as a target for cell growth

31 March 2020

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Nucleophosmin is a novel Bax chaperone that regulates apoptotic cell death.

31 March 2020

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Recruitment of phosphorylated NPM1 to sites of DNA damage through RNF8-dependent ubiquitin conjugates

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.646

ARF function does not require p53 stabilization or Mdm2 relocalization

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.646

Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.646

Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.646

N-terminal polyubiquitination and degradation of the Arf tumor suppressor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Influence of nucleophosmin/B23 on DNA binding and transcriptional activity of the androgen receptor in prostate cancer cell

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.646

DNMT3A Mutations in Acute Myeloid Leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleophosmin suppresses oncogene-induced apoptosis and senescence and enhances oncogenic cooperation in cells with genomic instability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleophosmin regulates cell cycle progression and stress response in hematopoietic stem/progenitor cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Hypoxia-induced nucleophosmin protects cell death through inhibition of p53.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Negative regulation of p53 by nucleophosmin antagonizes stress-induced apoptosis in human normal and malignant hematopoietic cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.646

Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphoma

31 March 2020

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Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation

31 March 2020

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Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival

31 March 2020

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Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.

31 March 2020

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Tumor suppression by Ink4a-Arf: progress and puzzles

31 March 2020

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Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleophosmin sets a threshold for p53 response to UV radiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Cytoplasmic localization of NPM in myeloid leukemias is dictated by gain-of-function mutations that create a functional nuclear export signal.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in transcriptionally active nucleoli

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Late relapse of acute myeloid leukemia with mutated NPM1 after eight years: evidence of NPM1 mutation stability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.646

Influence of new molecular prognostic markers in patients with karyotypically normal acute myeloid leukemia: recent advances

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.646

Posttranscriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Transcription regulation of the rRNA gene by a multifunctional nucleolar protein, B23/nucleophosmin, through its histone chaperone activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Identification of nuclear export inhibitors with potent anticancer activity in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleophosmin: a versatile molecule associated with hematological malignancies.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Effects of interphase and mitotic phosphorylation on the mobility and location of nucleolar protein B23

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

SMT3IP1, a nucleolar SUMO-specific protease, deconjugates SUMO-2 from nucleolar and cytoplasmic nucleophosmin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Phosphoproteome analysis of the human mitotic spindle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Ebp1 association with nucleophosmin/B23 is essential for regulating cell proliferation and suppressing apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Successful all-trans retinoic acid treatment of acute promyelocytic leukemia in a patient with NPM/RAR fusion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Identification of nucleophosmin/B23, an acidic nucleolar protein, as a stimulatory factor for in vitro replication of adenovirus DNA complexed with viral basic core proteins.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

The RNA binding activity of a ribosome biogenesis factor, nucleophosmin/B23, is modulated by phosphorylation with a cell cycle-dependent kinase and by association with its subtype

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleophosmin is selectively deposited on mRNA during polyadenylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukemia: Impact on WHO classification

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Modification of nucleolar protein B23 after exposure to ionizing radiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Stability of nucleolar versus non-nucleolar forms of human p14(ARF).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Identification of Ag-NOR proteins, markers of proliferation related to ribosomal gene activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

31 March 2020

Assisted protein folding

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Preferential cleavage in pre-ribosomal RNA byprotein B23 endoribonuclease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Acetylated NPM1 localizes in the nucleoplasm and regulates transcriptional activation of genes implicated in oral cancer manifestation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Role of protein kinase CK2 phosphorylation in the molecular chaperone activity of nucleolar protein b23

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleolar protein B23 stimulates nuclear import of the HIV-1 Rev protein and NLS-conjugated albumin.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleolar protein B23 has molecular chaperone activities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Sumoylation induced by the Arf tumor suppressor: a p53-independent function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleolar protein B23.1 binds to retinoblastoma protein and synergistically stimulates DNA polymerase alpha activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Thr199 phosphorylation targets nucleophosmin to nuclear speckles and represses pre-mRNA processing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Restoration of p53 function leads to tumour regression in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Protein B23/nucleophosmin/numatrin nuclear dynamics in relation to protein kinase CK2 and apoptotic activity in prostate cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

p53-independent functions of the p19(ARF) tumor suppressor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleolar Arf sequesters Mdm2 and activates p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Involvement of nucleophosmin/B23 in the response of HeLa cells to UV irradiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Resistance to UV-induced cell-killing in nucleophosmin/B23 over-expressed NIH 3T3 fibroblasts: enhancement of DNA repair and up-regulation of PCNA in association with nucleophosmin/B23 over-expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleophosmin/B23 interacts with p21WAF1/CIP1 and contributes to its stability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nek2A kinase regulates the localization of numatrin to centrosome in mitosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

B23 acts as a nucleolar stress sensor and promotes cell survival through its dynamic interaction with hnRNPU and hnRNPA1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Shuttling imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleophosmin is essential for ribosomal protein L5 nuclear export

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of polo-like kinase 1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

NPM1 mutations in myelodysplastic syndromes and acute myeloid leukemia with normal karyotype

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.646

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.646

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21278791%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference