Novel roles for Slits and netrins: axon guidance cues as anticancer targets? (Q37843457)

24 August 2017

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title

Novel roles for Slits and netrins: axon guidance cues as anticancer targets? (English)

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24 August 2017

author

Céline Delloye-Bourgeois

series ordinal

2

object named as

Céline Delloye-Bourgeois

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author name string

Patrick Mehlen

series ordinal

1

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24 August 2017

Alain Chédotal

series ordinal

3

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24 August 2017

language of work or name

English

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publication date

17 February 2011

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24 August 2017

published in

Nature Reviews Cancer

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24 August 2017

volume

11

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24 August 2017

issue

3

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24 August 2017

page(s)

188-197

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Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord

24 August 2017

cites work

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The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6.

31 March 2020

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A novel member of the netrin family, beta-netrin, shares homology with the beta chain of laminin: identification, expression, and functional characterization

31 March 2020

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Binding of netrin-4 to laminin short arms regulates basement membrane assembly

31 March 2020

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Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex

31 March 2020

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Moving away from the midline: new developments for Slit and Robo

31 March 2020

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Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene

31 March 2020

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UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues

31 March 2020

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Identification of a chromosome 18q gene that is altered in colorectal cancers

31 March 2020

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Role of the dependence receptor DCC in colorectal cancer pathogenesis

31 March 2020

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Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies

31 March 2020

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Making the case for DCC and UNC5C as tumor-suppressor genes in the colon

31 March 2020

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The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment

31 March 2020

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Deleted in colorectal cancer is a putative conditional tumor-suppressor gene inactivated by promoter hypermethylation in head and neck squamous cell carcinoma

31 March 2020

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Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene

31 March 2020

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Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progression

31 March 2020

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Frequent epigenetic inactivation of the SLIT2 gene in chronic and acute lymphocytic leukemia

31 March 2020

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Epigenetic inactivation of SLIT3 and SLIT1 genes in human cancers.

31 March 2020

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SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium

31 March 2020

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Quantification of expression of netrins, slits and their receptors in human prostate tumors

31 March 2020

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Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer

31 March 2020

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Interference with netrin-1 and tumor cell death in non-small cell lung cancer

31 March 2020

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Netrin-1 acts as a survival factor for aggressive neuroblastoma

31 March 2020

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Netrin-1 mediates early events in pancreatic adenocarcinoma progression, acting on tumor and endothelial cells

31 March 2020

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Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression

31 March 2020

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NF-kappaB regulates netrin-1 expression and affects the conditional tumor suppressive activity of the netrin-1 receptors

31 March 2020

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Netrin-1 controls colorectal tumorigenesis by regulating apoptosis

31 March 2020

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Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins

31 March 2020

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Netrin-4 regulates angiogenic responses and tumor cell growth

31 March 2020

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Netrin-4 induces lymphangiogenesis in vivo

31 March 2020

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Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B.

31 March 2020

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Netrins: beyond the brain

31 March 2020

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Slits and their receptors

31 March 2020

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Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion

31 March 2020

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Assembly and tissue functions of early embryonic laminins and netrins.

31 March 2020

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Traction on immobilized netrin-1 is sufficient to reorient axons

31 March 2020

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Netrins guide Drosophila commissural axons at short range.

31 March 2020

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Inhibition of medulloblastoma cell invasion by Slit

31 March 2020

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Slit2 inhibits glioma cell invasion in the brain by suppression of Cdc42 activity.

31 March 2020

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Slit-2 induces a tumor-suppressive effect by regulating beta-catenin in breast cancer cells

31 March 2020

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SLIT2 attenuation during lung cancer progression deregulates beta-catenin and E-cadherin and associates with poor prognosis

31 March 2020

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Slit protein-mediated inhibition of CXCR4-induced chemotactic and chemoinvasive signaling pathways in breast cancer cells

31 March 2020

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Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration

31 March 2020

1 reference

The Slit/Robo system suppresses hepatocyte growth factor-dependent invasion and morphogenesis

31 March 2020

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Directional guidance of neuronal migration in the olfactory system by the protein Slit

31 March 2020

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Molecular Mechanisms Controlling Midline Crossing by Precerebellar Neurons

31 March 2020

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The neuronal guidance cue Slit2 induces targeted migration and may play a role in brain metastasis of breast cancer cells

31 March 2020

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Slit2 involvement in glioma cell migration is mediated by Robo1 receptor.

31 March 2020

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MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor

31 March 2020

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MicroRNA-218 Regulates Vascular Patterning by Modulation of Slit-Robo Signaling

31 March 2020

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31 March 2020

The Hallmarks of Cancer

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The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis

31 March 2020

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Netrin-1 acts as a survival factor via its receptors UNC5H and DCC.

31 March 2020

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p53RDL1 regulates p53-dependent apoptosis

31 March 2020

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A newly identified dependence receptor UNC5H4 is induced during DNA damage-mediated apoptosis and transcriptional target of tumor suppressor p53.

31 March 2020

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Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B

31 March 2020

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Netrin-1 is a survival factor during commissural neuron navigation

31 March 2020

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Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesis

31 March 2020

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The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase

31 March 2020

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The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex

31 March 2020

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Autoinhibition of UNC5b revealed by the cytoplasmic domain structure of the receptor

31 March 2020

1 reference

Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer.

31 March 2020

1 reference

Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia

31 March 2020

1 reference

Slit2 inhibits growth and metastasis of fibrosarcoma and squamous cell carcinoma

31 March 2020

1 reference

Slits and Roundabouts in cancer, tumour angiogenesis and endothelial cell migration

31 March 2020

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Netrin-1 role in angiogenesis: to be or not to be a pro-angiogenic factor?

31 March 2020

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The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system

31 March 2020

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Robo4 signaling in endothelial cells implies attraction guidance mechanisms.

31 March 2020

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Netrins promote developmental and therapeutic angiogenesis.

31 March 2020

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Transcriptional network governing the angiogenic switch in human pancreatic cancer

31 March 2020

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Repulsive axon guidance molecule Slit3 is a novel angiogenic factor

31 March 2020

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Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity

31 March 2020

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Soluble Robo4 receptor inhibits in vivo angiogenesis and endothelial cell migration

31 March 2020

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Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

31 March 2020

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Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity

31 March 2020

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Robo4 is a vascular-specific receptor that inhibits endothelial migration

31 March 2020

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Increased immunoreactivity to SLIT/ROBO1 in ovarian endometriomas: a likely constituent biomarker for recurrence

31 March 2020

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Robo4 counteracts VEGF signaling.

31 March 2020

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Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis

31 March 2020

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The Rac1 regulator ELMO1 controls vascular morphogenesis in zebrafish.

31 March 2020

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The netrin receptor UNC5B promotes angiogenesis in specific vascular beds

31 March 2020

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Overexpression of netrin-1 induces neovascularization in the adult mouse brain

31 March 2020

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Endothelial cell apoptosis in angiogenesis and vessel regression

31 March 2020

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New insights into the function and regulation of endothelial cell apoptosis

31 March 2020

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Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis

31 March 2020

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Interfering with multimerization of netrin-1 receptors triggers tumor cell death.

31 March 2020

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The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline.

31 March 2020

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The neogenin intracellular domain regulates gene transcription via nuclear translocation

31 March 2020

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Deleted in Colorectal Cancer (DCC) encodes a netrin receptor

31 March 2020

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Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor

31 March 2020

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Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation

31 March 2020

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DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1

31 March 2020

1 reference

Slit is the midline repellent for the robo receptor in Drosophila.

31 March 2020

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slit: an EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system

31 March 2020

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slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains

31 March 2020

2 references

31 March 2020

12 December 2020

Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion

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roundabout4 is essential for angiogenesis in vivo

31 March 2020

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Neuronal clues to vascular guidance

31 March 2020

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Robo1 and Robo2 are homophilic binding molecules that promote axonal growth

31 March 2020

1 reference

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

31 March 2020

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Reduced expression of deleted colorectal carcinoma (DCC) protein in established colon cancers

31 March 2020

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Prognostic significance of allelic lost at chromosome 18q21 for stage II colorectal cancer.

31 March 2020

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Suppressed tumorigenicity of human endometrial cancer cells by the restored expression of the DCC gene

31 March 2020

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The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors

31 March 2020

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Slit-2/Robo-1 modulates the CXCL12/CXCR4-induced chemotaxis of T cells

31 March 2020

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Neuronal repellent Slit2 inhibits dendritic cell migration and the development of immune responses.

31 March 2020

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The axonal repellent, Slit2, inhibits directional migration of circulating neutrophils

31 March 2020

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The Chemorepellent Slit3 Promotes Monocyte Migration

31 March 2020

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Slit2 Regulates Attractive Eosinophil and Repulsive Neutrophil Chemotaxis through Differential srGAP1 Expression during Lung Inflammation

31 March 2020

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Netrin-1 inhibits leukocyte migration in vitro and in vivo.

31 March 2020

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Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers

31 March 2020

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Homozygous deletions at 3p12 in breast and lung cancer

31 March 2020

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Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers

31 March 2020

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Frequent epigenetic inactivation of the SLIT2 gene in gliomas

31 March 2020

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Functional implication of Netrin expression in malignant melanoma.

31 March 2020

1 reference

12 December 2020

SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers

1 reference

12 December 2020

SLIT2 axon guidance molecule is frequently inactivated in colorectal cancer and suppresses growth of colorectal carcinoma cells

1 reference

12 December 2020

Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer

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12 December 2020

Identifiers

DOI

10.1038/NRC3005

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24 August 2017

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