Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development (Q37855897)

24 August 2017

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title

Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development (English)

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24 August 2017

Alastair J Barr

1

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24 August 2017

1 October 2010

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Future Medicinal Chemistry

24 August 2017

14

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based on heuristic

inferred from page(s)

published in

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24 August 2017

2

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24 August 2017

10

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24 August 2017

1563-1576

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Physiological signaling specificity by protein tyrosine phosphatases

24 August 2017

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

The protein kinase complement of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Protein tyrosine phosphatases in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Serine/threonine phosphatases: mechanism through structure

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Targeting the PTPome in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Protein tyrosine phosphatases, new targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Protein-tyrosine phosphatases and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Mutational analysis of the tyrosine phosphatome in colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Protein-tyrosine phosphatase sigma is associated with ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Drug discovery and protein tyrosine phosphatases.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

A brake becomes an accelerator: PTP1B--a new therapeutic target for breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Cloning and expression of a protein-tyrosine-phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Structure determination of T cell protein-tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Strategies for developing protein tyrosine phosphatase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Catalytic inactivation of protein tyrosine phosphatase CD45 and protein tyrosine phosphatase 1B by polyaromatic quinones

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Protein tyrosine phosphatase: enzymatic assays

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

A microfluidics-based mobility shift assay to discover new tyrosine phosphatase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Neuronal PTP1B regulates body weight, adiposity and leptin action.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Design and synthesis of phosphonodifluoromethyl phenylalanine (F2Pmp): a useful phosphotyrosyl mimetic

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Synthesis and cell-based activity of a potent and selective protein tyrosine phosphatase 1B inhibitor prodrug.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

The Structural Basis for the Selectivity of Benzotriazole Inhibitors of PTP1B

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Fragment-based lead discovery using X-ray crystallography.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Molecular docking and high-throughput screening for novel inhibitors of protein tyrosine phosphatase-1B.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Ertiprotafib improves glycemic control and lowers lipids via multiple mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Novel 2-aryl-naphtho[1,2-d]oxazole derivatives as potential PTP-1B inhibitors showing antihyperglycemic activities

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT-551.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Allosteric inhibition of protein tyrosine phosphatase 1B.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Syntheses and biological activities of a novel group of steroidal derived inhibitors for human Cdc25A protein phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Nonreceptor protein-tyrosine phosphatases in immune cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Crystal structure of the tyrosine phosphatase SHP-2

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

The tyrosine phosphatase Shp2 (PTPN11) in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

SHP2 is up-regulated in breast cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Oncogenic mechanisms of the Helicobacter pylori CagA protein

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Shp2, a novel oncogenic tyrosine phosphatase and potential therapeutic target for human leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Discovery of a novel shp2 protein tyrosine phosphatase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

2-Thiazolylimino/heteroarylimino-5-arylidene-4-thiazolidinones as new agents with SHP-2 inhibitory action

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Gold(I) phosphine mediated selective inhibition of lymphoid tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Large-scale structural analysis of the classical human protein tyrosine phosphatome

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

In silico screening for PTPN22 inhibitors: active hits from an inactive phosphatase conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

MAPK-specific tyrosine phosphatases: new targets for drug discovery?

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Synaptic plasticity: one STEP at a time

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

A monoclonal antibody against CD148, a receptor-like tyrosine phosphatase, inhibits endothelial-cell growth and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Mechanisms linking obesity to insulin resistance and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.241

21 January 2018

Identifiers

DOI

10.4155/FMC.10.241

1 reference

24 August 2017

1 reference

PubMed ID

21426149