Human toxin-based recombinant immunotoxins/chimeric proteins as a drug delivery system for targeted treatment of human diseases (Q37859775)

24 August 2017

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title

Human toxin-based recombinant immunotoxins/chimeric proteins as a drug delivery system for targeted treatment of human diseases (English)

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24 August 2017

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Haya Lorberboum-Galski

series ordinal

1

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24 August 2017

language of work or name

English

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publication date

1 April 2011

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Expert Opinion on Drug Delivery

24 August 2017

published in

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24 August 2017

volume

8

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24 August 2017

issue

5

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24 August 2017

page(s)

605-621

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Humanized immunotoxins: a new generation of immunotoxins for targeted cancer therapy

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Continuous cultures of fused cells secreting antibody of predefined specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Assembly of a functional immunoglobulin Fv fragment in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Immunotoxin treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Identification of residues that stabilize the single-chain Fv of monoclonal antibodies B3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Remodeling domain interfaces to enhance heterodimer formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malig

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Biological correlates of acute hypersensitivity events with DAB(389)IL-2 (denileukin diftitox, ONTAK) in cutaneous T-cell lymphoma: decreased frequency and severity with steroid premedication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Phase II study of denileukin diftitox for relapsed/refractory B-Cell non-Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Targeted cancer therapy with gonadotropin-releasing hormone chimeric proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

I.V. Administration of L-GNRH-PE66 efficiently inhibits growth of colon adenocarcinoma xenografts in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Linker-based GnRH-PE chimeric proteins inhibit cancer growth in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Utilizing chimeric proteins for exploring the cellular fate of endogenous proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Antitumor activity of DAB389IL-2 fusion toxin in mycosis fungoides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Surface antigens/receptors for targeted cancer treatment: the GnRH receptor/binding site for targeted adenocarcinoma therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Targeted elimination of cells expressing the high-affinity receptor for IgE (Fc epsilon RI) by a Pseudomonas exotoxin-based chimeric protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

A novel antigen-toxin chimeric protein: myelin basic protein-pseudomonas exotoxin (MBP-PE 40) for treatment of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

High-pressure-liquid-chromatographic and fluorimetric methods for the determination of adenine released from ribosomes by ricin and gelonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Biologically active interleukin 2-ricin A chain fusion proteins may require intracellular proteolytic cleavage to exhibit a cytotoxic effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Expression and activity of a recombinant chimeric protein composed of pokeweed antiviral protein and of human interleukin-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Construction, expression, and characterization of BD1-G28-5 sFv, a single-chain anti-CD40 immunotoxin containing the ribosome-inactivating protein bryodin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Construction and characterization of novel, recombinant immunotoxins targeting the Her2/neu oncogene product: in vitro and in vivo studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Engineering and biological characterization of VB6-845, an anti-EpCAM immunotoxin containing a T-cell epitope-depleted variant of the plant toxin bouganin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Reconstitution of diphtheria toxin from two nontoxic cross-reacting mutant proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Single-chain immunotoxin fusions between anti-Tac and Pseudomonas exotoxin: relative importance of the two toxin disulfide bonds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

A proper amino terminus of diphtheria toxin is important for cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Recombinant immunotoxins containing truncated bacterial toxins for the treatment of hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Treatment of hepatocellular carcinoma in a mouse xenograft model with an immunotoxin which is engineered to eliminate vascular leak syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

A recombinant immunotoxin targeting CD22 with low immunogenicity, low nonspecific toxicity, and high antitumor activity in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

21 January 2018

The BCL-2 family reunion

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https://api.crossref.org/works/10.1517%2F17425247.2011.566269

The BCL-2 protein family: opposing activities that mediate cell death

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Mitochondria and cell death: outer membrane permeabilization and beyond

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Cytochrome c: functions beyond respiration

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2011.566269

The role of BH3-only proteins in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Mechanism of action of interleukin-2 (IL-2)-Bax, an apoptosis-inducing chimaeric protein targeted against cells expressing the IL-2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Cardiac allograft survival in mice treated with IL-2-PE40.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Cytotoxic activity of an interleukin 2-Pseudomonas exotoxin chimeric protein produced in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Immunospecific suppression of encephalitogenic-activated T lymphocytes by chimeric cytotoxin IL-2-PE40.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Interleukin-2 (IL-2) receptor alpha, beta and gamma subunit expression as a function of B-cell lineage ontogeny: the use of IL-2-PE66(4Glu) to characterize internalization via IL-2 receptor subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Interleukin-2 Pseudomonas exotoxin chimeric protein is cytotoxic to B cell cultures derived from myasthenia gravis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Apoptosis-inducing human-origin Fcepsilon-Bak chimeric proteins for targeted elimination of mast cells and basophils: a new approach for allergy treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

BID: a novel BH3 domain-only death agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Signal transduction mediated by Bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

scFv-mediated delivery of truncated BID suppresses HER2-positive osteosarcoma growth and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Selective cytotoxicity to HER2-positive tumor cells by a recombinant e23sFv-TD-tBID protein containing a furin cleavage sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Caspases in apoptosis and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Potent inhibition of human gastric cancer by HER2-directed induction of apoptosis with anti-HER2 antibody and caspase-3 fusion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

A caspase-6 and anti-HER2 antibody chimeric tumor-targeted proapoptotic molecule decreased metastasis of human osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Therapeutic potency of IL2-caspase 3 targeted treatment in a murine experimental model of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

A fusion protein composed of IL-2 and caspase-3 ameliorates the outcome of experimental inflammatory colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

IL2-caspase3 chimeric protein controls lymphocyte reactivity by targeted apoptosis, leading to amelioration of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Delivery and therapeutic potential of human granzyme B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Development of novel, highly cytotoxic fusion constructs containing granzyme B: unique mechanisms and functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Granzyme B delivery via perforin is restricted by size, but not by heparan sulfate-dependent endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Granzyme B binds to target cells mostly by charge and must be added at the same time as perforin to trigger apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

21 January 2018

Granzymes at a glance

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF45.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Molecular cloning and characterization of human caspase-activated DNase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Apoptotic DNA fragmentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Induction of programmed cell death in ErbB2/HER2-expressing cancer cells by targeted delivery of apoptosis-inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Contenders in FasL/TNF death signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Apo2L/TRAIL and its death and decoy receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

An antagonist decoy receptor and a death domain-containing receptor for TRAIL

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Targeting TRAIL agonistic receptors for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Target cell-restricted and -enhanced apoptosis induction by a scFv:sTRAIL fusion protein with specificity for the pancarcinoma-associated antigen EGP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Lethal effect of the anti-Fas antibody in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

CD7-restricted activation of Fas-mediated apoptosis: a novel therapeutic approach for acute T-cell leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Cloning and cytotoxicity of a human pancreatic RNase immunofusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Human pancreatic RNase1-human epidermal growth factor fusion: an entirely human 'immunotoxin analog' with cytotoxic properties against squamous cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Inhibition of cell growth by a fused protein of human ribonuclease 1 and human basic fibroblast growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Targeting activated lymphocytes with an entirely human immunotoxin analogue: human pancreatic RNase1-human IL-2 fusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Immunokinases, a novel class of immunotherapeutics for targeted cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

Targeted restoration of down-regulated DAPK2 tumor suppressor activity induces apoptosis in Hodgkin lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.566269

10.1517/17425247.2011.566269

21 January 2018

Identifiers

DOI

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24 August 2017

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