The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks (Q37888122)

24 August 2017

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title

The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks (English)

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24 August 2017

Simon Bekker-Jensen

1

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author name string

Niels Mailand

series ordinal

2

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PubMed ID

21664912

24 August 2017

language of work or name

English

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publication date

12 June 2011

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24 August 2017

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24 August 2017

585

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24 August 2017

18

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24 August 2017

2914-2919

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Repair of endogenous DNA damage

24 August 2017

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

DNA double-strand break repair: all's well that ends well

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Genome maintenance mechanisms for preventing cancer

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

The DNA-damage response in human biology and disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

The DNA damage response: ten years after

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

The DNA Damage Response: Making It Safe to Play with Knives

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

The emerging role of nuclear architecture in DNA repair and genome maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Choreography of recombination proteins during the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Assembly and function of DNA double-strand break repair foci in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

H2AX: the histone guardian of the genome

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

DNA resection in eukaryotes: deciding how to fix the break

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Mechanism of eukaryotic homologous recombination

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

The ubiquitous role of ubiquitin in the DNA damage response

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

More modifiers move on DNA damage

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

HERC2 is an E3 ligase that targets BRCA1 for degradation.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Structure of RCC1 chromatin factor bound to the nucleosome core particle

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Modification of proteins by ubiquitin and ubiquitin-like proteins

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Principles of ubiquitin and SUMO modifications in DNA repair.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

SUMO-targeted ubiquitin ligases in genome stability.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

SUMO-1-dependent allosteric regulation of thymine DNA glycosylase alters subnuclear localization and CBP/p300 recruitment

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

SUMO-1 regulates the conformational dynamics of thymine-DNA Glycosylase regulatory domain and competes with its DNA binding activity

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

A genomic and functional inventory of deubiquitinating enzymes

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Human USP3 is a chromatin modifier required for S phase progression and genome stability

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Modification in reverse: the SUMO proteases

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Histone ubiquitination: triggering gene activity

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

BRCA1 and its toolbox for the maintenance of genome integrity

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Histone ubiquitination associates with BRCA1-dependent DNA damage response

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

The multiple facets of histone H4-lysine 20 methylation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

Regulation of homologous recombination by RNF20-dependent H2B ubiquitination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.056

10.1016/J.FEBSLET.2011.05.056

21 January 2018

Identifiers

DOI

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24 August 2017

1 reference

PubMed ID

21664912