The power and richness of modelling tauopathies in Drosophila (Q37890901)

24 August 2017

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title

The power and richness of modelling tauopathies in Drosophila (English)

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24 August 2017

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Katerina Papanikolopoulou

series ordinal

1

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24 August 2017

Efthimios M C Skoulakis

series ordinal

2

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24 August 2017

publication date

17 June 2011

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24 August 2017

published in

Molecular Neurobiology

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24 August 2017

volume

44

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24 August 2017

issue

1

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24 August 2017

page(s)

122-133

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Drosophila as a model for human neurodegenerative disease

24 August 2017

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Using Drosophila models of neurodegenerative diseases for drug discovery.

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Mushroom body memoir: from maps to models

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There are many ways to train a fly.

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Learning and memory associated with aggression in Drosophila melanogaster

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Role of tau protein in both physiological and pathological conditions.

21 January 2018

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Tau in Alzheimer disease and related tauopathies

21 January 2018

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Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

21 January 2018

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A protein factor essential for microtubule assembly

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Structure and novel exons of the human tau gene

21 January 2018

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Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

21 January 2018

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Developmentally regulated expression of specific tau sequences

21 January 2018

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Tau protein binds to microtubules through a flexible array of distributed weak sites

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Competition for microtubule-binding with dual expression of tau missense and splice isoforms

21 January 2018

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Neuronal microtubules: when the MAP is the roadblock

21 January 2018

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Differential regulation of dynein and kinesin motor proteins by tau

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Role of tau phosphorylation by glycogen synthase kinase-3beta in the regulation of organelle transport

21 January 2018

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Subpopulations of tau interact with microtubules and actin filaments in various cell types.

21 January 2018

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Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

21 January 2018

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Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Tau is required for neurite outgrowth and growth cone motility of chick sensory neurons

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Microtubule-associated protein tau in development, degeneration and protection of neurons

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Function of tau protein in adult newborn neurons

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Biochemistry of Tau in Alzheimer's disease and related neurological disorders.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Phosphorylation of Tau at Thr212, Thr231, and Ser262 Combined Causes Neurodegeneration

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Differential effects of Tau on the integrity and function of neurons essential for learning in Drosophila.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Post-translational modifications of tau protein in Alzheimer's disease

21 January 2018

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Insulin and Insulin-like Growth Factor-1 Regulate Tau Phosphorylation in Cultured Human Neurons

21 January 2018

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Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

21 January 2018

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Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

21 January 2018

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Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease

21 January 2018

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Tau protein as a differential biomarker of tauopathies

21 January 2018

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Tau oligomerization: a role for tau aggregation intermediates linked to neurodegeneration

21 January 2018

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Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model

21 January 2018

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Mechanisms of tau-induced neurodegeneration

21 January 2018

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Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses

21 January 2018

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The role of tau in neurodegeneration

21 January 2018

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The GAL4 system as a tool for unravelling the mysteries of the Drosophila nervous system.

21 January 2018

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GAL4 system in Drosophila: a fly geneticist's Swiss army knife

21 January 2018

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Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

21 January 2018

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The locus elav of Drosophila melanogaster is expressed in neurons at all developmental stages.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Oxidative stress mediates tau-induced neurodegeneration in Drosophila

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Olfactory memory formation in Drosophila: from molecular to systems neuroscience.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Phosphorylation differentiates tau-dependent neuronal toxicity and dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Changes in adult neurogenesis in neurodegenerative diseases: cause or consequence?

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Pathological glial tau accumulations in neurodegenerative disease: review and case report

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Glial cell biology in Drosophila and vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Tau suppression in a neurodegenerative mouse model improves memory function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Classical conditioning and retention in normal and mutantDrosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Learning and memory deficits upon TAU accumulation in Drosophila mushroom body neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Spatiotemporal rescue of memory dysfunction in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

The genetics of Drosophila transgenics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Glass encodes a site-specific DNA-binding protein that is regulated in response to positional signals in the developing Drosophila eye.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Cell type-specific processing of human Tau proteins in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Tau phosphorylation sites work in concert to promote neurotoxicity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Drosophila notal bristle as a novel assessment tool for pathogenic study of Tau toxicity and screening of therapeutic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Drosophila melanogaster in the study of human neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Tau and tau reporters disrupt central projections of sensory neurons in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Divide and die: cell cycle events as triggers of nerve cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Identification and characterization of the Drosophila tau homolog.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Par-1 and Tau regulate the anterior-posterior gradient of microtubules in Drosophila oocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Study of tauopathies by comparing Drosophila and human tau in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Overexpression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Disruption of neuronal function by soluble hyperphosphorylated tau in a Drosophila model of tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-011-8193-1

Genetic modifiers of tauopathy in Drosophila.

21 January 2018

1 reference

12 December 2020

Activation of protein phosphatase 2B and hyperphosphorylation of Tau in Alzheimer's disease

1 reference

12 December 2020

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain

1 reference

12 December 2020

A comparison of the neuronal dysfunction caused by Drosophila tau and human tau in a Drosophila model of tauopathies

1 reference

12 December 2020

Modelling cell and isoform type specificity of tauopathies in Drosophila.

1 reference

12 December 2020

Tau binds to the distal axon early in development of polarity in a microtubule- and microfilament-dependent manner

1 reference

12 December 2020

Gene targeting by homologous recombination in Drosophila

1 reference

12 December 2020

In vivo dynamics of axon pathfinding in the Drosophilia CNS: a time-lapse study of an identified motorneuron.

1 reference

12 December 2020

Modeling Tauopathy in the fruit fly Drosophila melanogaster

1 reference

12 December 2020

Tau is enriched on dynamic microtubules in the distal region of growing axons

1 reference

12 December 2020

Pathological tau: a loss of normal function or a gain in toxicity?

1 reference

12 December 2020

Drosophila long-term memory formation involves regulation of cathepsin activity

1 reference

12 December 2020

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments

1 reference

12 December 2020

Evidence for cdk5 as a Major Activity Phosphorylating Tau Protein in Porcine Brain Extract1

1 reference

12 December 2020

The molecular parameters of tau pathology. Tau as a killer and a witness

1 reference

12 December 2020

Tauopathies: recent insights into old diseases

1 reference

12 December 2020

Thorn-shaped astrocytes: possibly secondarily induced tau-positive glial fibrillary tangles

1 reference

12 December 2020

The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila.

1 reference

12 December 2020

Expression of Drosophila glass protein and evidence for negative regulation of its activity in non-neuronal cells by another DNA-binding protein.

1 reference

12 December 2020

Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization

1 reference

12 December 2020

10.1007/S12035-011-8193-1

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release_iid6iksngfh73d5wfypzsvy7am

24 August 2017

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https://api.fatcat.wiki/v0/release/iid6iksngfh73d5wfypzsvy7am

24 November 2022

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