Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1. (Q46689310)

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24 December 2019

title

Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1 (English)

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24 December 2019

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1

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24 December 2019

author name string

Yuzuru Imai

series ordinal

2

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24 December 2019

Bingwei Lu

series ordinal

3

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24 December 2019

language of work or name

English

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publication date

1 January 2007

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24 December 2019

published in

Journal of Neuroscience

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24 December 2019

volume

27

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24 December 2019

issue

3

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24 December 2019

page(s)

574-581

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Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

24 December 2019

cites work

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Modulation of tau phosphorylation and intracellular localization by cellular stress

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Microtubule-Affinity Regulating Kinase (MARK) Is Tightly Associated with Neurofibrillary Tangles in Alzheimer Brain: A Fluorescence Resonance Energy Transfer Study

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PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling

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Activation of MKK6, an upstream activator of p38, in Alzheimer's disease.

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Novel genomic cDNA hybrids produce effective RNA interference in adult Drosophila.

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Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

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Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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12 December 2020

Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity

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12 December 2020

A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity

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12 December 2020

Cdk5 is a key factor in tau aggregation and tangle formation in vivo.

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12 December 2020

Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1

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12 December 2020

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

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12 December 2020

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

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12 December 2020

MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1

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12 December 2020

The p38 MAP kinase signaling pathway in Alzheimer's disease.

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12 December 2020

P38 MAP kinase is activated at early stages in Alzheimer's disease brain.

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Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

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12 December 2020

Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network

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12 December 2020

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

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12 December 2020

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

1 reference

12 December 2020

PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila.

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12 December 2020

Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4

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12 December 2020

Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity

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12 December 2020

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

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12 December 2020

The yeast par-1 homologs kin1 and kin2 show genetic and physical interactions with components of the exocytic machinery

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12 December 2020

Characterization of a double (amyloid precursor protein-tau) transgenic: tau phosphorylation and aggregation

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12 December 2020

Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies

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12 December 2020

Microtubule affinity-regulating kinase 1 (MARK1) is activated by electroconvulsive shock in the rat hippocampus

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12 December 2020

Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory.

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12 December 2020

gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo.

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12 December 2020

LKB1-dependent signaling pathways

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12 December 2020

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

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12 December 2020

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

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12 December 2020

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

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12 December 2020

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

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12 December 2020

Frontotemporal dementia and parkinsonism linked to chromosome 17: a consensus conference. Conference Participants

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12 December 2020

Tau is a candidate gene for chromosome 17 frontotemporal dementia

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12 December 2020

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

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12 December 2020

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

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12 December 2020

10.1523/JNEUROSCI.5094-06.2007

Identifiers

DOI

1 reference

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24 December 2019

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24 December 2019

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