Is fat so bad? Modulation of endoplasmic reticulum stress by lipid droplet formation (Q37897618)

25 August 2017

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title

Is fat so bad? Modulation of endoplasmic reticulum stress by lipid droplet formation (English)

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25 August 2017

endoplasmic reticulum

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author name string

Ivan Hapala

series ordinal

1

1 reference

PubMed ID

21729000

25 August 2017

Esther Marza

series ordinal

2

1 reference

PubMed ID

21729000

25 August 2017

Thierry Ferreira

series ordinal

3

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25 August 2017

1 June 2011

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25 August 2017

15

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based on heuristic

inferred from page(s)

published in

Biology of the Cell

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25 August 2017

103

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25 August 2017

6

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25 August 2017

271-285

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Control of fatty acid desaturation: a mechanism conserved from bacteria to humans.

25 August 2017

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Effect of intracellular lipid droplets on cytosolic Ca2+ and cell death during ischaemia-reperfusion injury in cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Dynamic activity of lipid droplets: protein phosphorylation and GTP-mediated protein translocation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Lipid droplet analysis in caveolin-deficient adipocytes: alterations in surface phospholipid composition and maturation defects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Phosphatidic acid plays a central role in the transcriptional regulation of glycerophospholipid synthesis in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Oleate inhibits steryl ester synthesis and causes liposensitivity in yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic beta-cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Conditions of endoplasmic reticulum stress stimulate lipid droplet formation in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Lipid dynamics in yeast under haem-induced unsaturated fatty acid and/or sterol depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Beta-cell dysfunction in subjects with impaired glucose tolerance and early type 2 diabetes: comparison of surrogate markers with first-phase insulin secretion from an intravenous glucose tolerance test

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Sterol and diacylglycerol acyltransferase deficiency triggers fatty acid-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

A block in endoplasmic reticulum-to-Golgi trafficking inhibits phospholipid synthesis and induces neutral lipid accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Dietary monounsaturated fatty acids are protective against metabolic syndrome and cardiovascular disease risk factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Demonstrated and inferred metabolism associated with cytosolic lipid droplets

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

1H NMR visible lipids in the life and death of cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Quality and quantity control at the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Proteomic insights into an expanded cellular role for cytoplasmic lipid droplets

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Endoplasmic reticulum stress and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

alpha-Linolenic acid protects renal cells against palmitic acid lipotoxicity via inhibition of endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Diabetes and apoptosis: lipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Dual localization of squalene epoxidase, Erg1p, in yeast reflects a relationship between the endoplasmic reticulum and lipid particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Regulation of hepatic lipogenesis by the transcription factor XBP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Endoplasmic reticulum stress signaling in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

ERAD: the long road to destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Targeting of proteins involved in sterol biosynthesis to lipid particles of the yeast Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

The biogenesis and functions of lipid bodies in animals, plants and microorganisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Lipid droplet-organelle interactions; sharing the fats

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

The recognition and retrotranslocation of misfolded proteins from the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Dissecting the ER-associated degradation of a misfolded polytopic membrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Cytoplasmic lipid droplets are sites of convergence of proteasomal and autophagic degradation of apolipoprotein B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Biogenesis of cytoplasmic lipid droplets: from the lipid ester globule in the membrane to the visible structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Good fat, essential cellular requirements for triacylglycerol synthesis to maintain membrane homeostasis in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Lipid-induced ER stress: synergistic effects of sterols and saturated fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Lipid-induced ER stress in yeast and β cells: parallel trails to a common fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

The metabolic syndrome: definition, global impact, and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Coupling endoplasmic reticulum stress to the cell death program

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Signal integration in the endoplasmic reticulum unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Fasting nonesterified fatty acid profiles in childhood and their relationship with adiposity, insulin sensitivity, and lipid levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Storage lipid synthesis is non-essential in yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

A yeast strain lacking lipid particles bears a defect in ergosterol formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Effect of lipid particle biogenesis on the subcellular distribution of squalene in the yeast Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Modulation of lipid droplet size and lipid droplet proteins by trans-10,cis-12 conjugated linoleic acid parallels improvements in hepatic steatosis in obese, insulin-resistant rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Bcl-2 family on guard at the ER.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

The surface of lipid droplets is a phospholipid monolayer with a unique Fatty Acid composition

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cells exposed to oleate compared to palmitate

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

The life of lipid droplets

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Roles and origins of leukocyte lipid bodies: proteomic and ultrastructural studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Obesity: stressing about unfolded proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

SnapShot: The Unfolded Protein Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

Phospholipid demixing and the birth of a lipid droplet.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

The unfolded protein response: a stress signaling pathway critical for health and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBC20100144

21 January 2018

Identifiers

DOI

10.1042/BC20100144

1 reference

25 August 2017

1 reference

PubMed ID

21729000