Emerging pathways and future targets for the molecular therapy of pancreatic cancer (Q37912219)

25 August 2017

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title

Emerging pathways and future targets for the molecular therapy of pancreatic cancer (English)

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25 August 2017

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8

Giampaolo Tortora

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25 August 2017

Vanja Vaccaro

1

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25 August 2017

Davide Melisi

2

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25 August 2017

Emilio Bria

3

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25 August 2017

Federica Cuppone

4

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25 August 2017

Ludovica Ciuffreda

5

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25 August 2017

Maria Simona Pino

6

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25 August 2017

Alain Gelibter

7

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25 August 2017

Francesco Cognetti

9

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25 August 2017

Michele Milella

10

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25 August 2017

language of work or name

English

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publication date

7 August 2011

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Expert Opinion on Therapeutic Targets

25 August 2017

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25 August 2017

15

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25 August 2017

10

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25 August 2017

1183-1196

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25 August 2017

Cancer statistics, 2010

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https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Clinical Cancer Advances 2009: major research advances in cancer treatment, prevention, and screening--a report from the American Society of Clinical Oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Stromal depletion goes on trial in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Non-Smad TGF-beta signals

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Specificity and versatility in tgf-beta signaling through Smads

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Smad transcription factors

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Transforming growth factor beta signaling via Ras in mesenchymal cells requires p21-activated kinase 2 for extracellular signal-regulated kinase-dependent transcriptional responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

TGF-beta activated kinase-1: new insights into the diverse roles of TAK1 in development and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Ubiquitin-mediated activation of TAK1 and IKK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Alterations in components of the TGF-beta superfamily signaling pathways in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Expression of transforming growth factor-beta-1 and p27Kip1 in pancreatic adenocarcinomas: relation with cell-cycle-associated proteins and clinicopathologic characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Transforming growth factor-beta and the immune response to malignant disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Cooperative induction of a tolerogenic dendritic cell phenotype by cytokines secreted by pancreatic carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Targeting the transforming growth factor-beta signalling pathway in metastatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Molecular mechanisms of pancreatic carcinogenesis.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Basics of TGF-beta and pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Development of TGF-beta signalling inhibitors for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Modulation of pancreatic cancer chemoresistance by inhibition of TAK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Targeting the transforming growth factor-beta signaling pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Companies waver in efforts to target transforming growth factor beta in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Switching TGFβ from a tumor suppressor to a tumor promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Antimetastatic role of Smad4 signaling in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Role of the insulin-like growth factor family in cancer development and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Insulin-like growth factor ligands, receptors, and binding proteins in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Inhibitors of insulin-like growth factor-1 receptor tyrosine kinase are preferentially cytotoxic to nutrient-deprived pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Pancreatic cancer: molecular pathogenesis and new therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Serum insulin-like growth factor-I, insulin-like growth factor binding protein-3, and the risk of pancreatic cancer death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Genetics and biology of pancreatic ductal adenocarcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Shh signaling and pancreatic cancer: implications for therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Biology and management of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Paracrine Hedgehog signaling in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

A paracrine requirement for hedgehog signalling in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Sonic hedgehog promotes desmoplasia in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Targeting Notch signaling in pancreatic cancer patients--rationale for new therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Notch signaling is required for exocrine regeneration after acute pancreatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Epidermal growth factor receptor-related protein inhibits cell growth and invasion in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Inhibition of angiogenesis and invasion by 3,3'-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Therapeutic intervention for Alzheimer's disease with γ-secretase inhibitors: still a viable option?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

REVIEW: γ-Secretase inhibitors for the treatment of Alzheimer's disease: The current state.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Missing pieces in the NF-kappaB puzzle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

NF-kappaB in cancer: from innocent bystander to major culprit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

NF-kappaB regulation in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

NF-kappa B as a target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Identification of an autoregulatory feedback pathway involving interleukin-1alpha in induction of constitutive NF-kappaB activation in pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Regulatory functions of ubiquitination in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

NF-kappaB at the crossroads of life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Secreted interleukin-1alpha induces a metastatic phenotype in pancreatic cancer by sustaining a constitutive activation of nuclear factor-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

NF-kappaB and cell-cycle regulation: the cyclin connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Ras oncogenes: split personalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

NF-kappaB and IKK as therapeutic targets in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

NF-kappaB inhibition: a double-edged sword in cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Can NF-kappaB be a target for novel and efficient anti-cancer agents?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Inhibitors of NF-kappaB signaling: 785 and counting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Adjuvant treatment of pancreatic carcinoma in a clinically adapted mouse resection model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Development of farnesyl transferase inhibitors: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Targeting targeted agents: open issues for clinical trial design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

DPC4/Smad4 Expression and Outcome in Pancreatic Ductal Adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Enhanced expression of the type II transforming growth factor-beta receptor is associated with decreased survival in human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.607438

Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells

21 January 2018

1 reference

3 January 2024

https://opencitations.net/index/api/v1/citations/10.1158/0008-5472.CAN-05-4281

Identifiers

DOI

10.1517/14728222.2011.607438

1 reference

25 August 2017

1 reference