Cartilage biology in osteoarthritis--lessons from developmental biology (Q37938702)

25 August 2017

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title

Cartilage biology in osteoarthritis--lessons from developmental biology (English)

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25 August 2017

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2

Frank Beier

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25 August 2017

Andrew A Pitsillides

1

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PubMed ID

21947178

25 August 2017

language of work or name

English

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publication date

27 September 2011

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Nature Reviews Rheumatology

25 August 2017

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25 August 2017

7

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25 August 2017

654-663

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25 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nrrheum.2011.129

25 August 2017

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Regulation of chondrocyte differentiation by the actin cytoskeleton and adhesive interactions

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Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice

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Reexpression of type IIA procollagen by adult articular chondrocytes in osteoarthritic cartilage

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Formation of glucuronic acid from uridinediphosphate glucuronic acid

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Src kinase inhibition promotes the chondrocyte phenotype.

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C-type natriuretic peptide regulates cellular condensation and glycosaminoglycan synthesis during chondrogenesis.

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Genetic disorders of the skeleton: a developmental approach

31 March 2020

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Sox9 is required for cartilage formation

31 March 2020

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Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors

31 March 2020

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Cartilage, SOX9 and Notch signals in chondrogenesis

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A critical evaluation of specific aspects of joint development

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Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development.

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Adult presentation of Stickler syndrome type III.

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Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.

31 March 2020

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Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women.

31 March 2020

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Rethinking the proximodistal axis of the vertebrate limb in the molecular era

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Making digit patterns in the vertebrate limb

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Heparan sulfate proteoglycans: coordinators of multiple signaling pathways during chondrogenesis

31 March 2020

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Regulation of Wnt signaling and embryo patterning by an extracellular sulfatase

31 March 2020

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Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways

31 March 2020

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Skeletal development and osteoarthritis

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Familial osteochondritis dissecans associated with early osteoarthritis and disproportionate short stature

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MicroRNA-140 plays dual roles in both cartilage development and homeostasis

31 March 2020

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Site specific osteoarthritis and the index to ring finger length ratio.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

A human chondrodysplasia due to a mutation in a TGF-beta superfamily member

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Genetic epidemiology of hip and knee osteoarthritis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Association of a single nucleotide polymorphism in Tbx4 with developmental dysplasia of the hip: a case-control study.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Differential regulation of GDF-5 and FGF-2/4 by immobilisation in ovo exposes distinct roles in joint formation.

31 March 2020

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Diverse range of fixed positional deformities and bone growth restraint provoked by flaccid paralysis in embryonic chicks

31 March 2020

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Early effects of embryonic movement: 'a shot out of the dark'.

31 March 2020

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Lineage tracing using matrilin-1 gene expression reveals that articular chondrocytes exist as the joint interzone forms

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Doublecortin is expressed in articular chondrocytes

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Expression of doublecortin reveals articular chondrocyte lineage in mouse embryonic limbs.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Role of canonical Wnt-signalling in joint formation.

31 March 2020

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Expression and function of Bapx1 during chick limb development.

31 March 2020

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Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Studies on the role of Cux1 in regulation of the onset of joint formation in the developing limb.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

An essential role for the interaction between hyaluronan and hyaluronan binding proteins during joint development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Coordination of chondrocyte differentiation and joint formation by alpha5beta1 integrin in the developing appendicular skeleton.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Multiple roles of mesenchymal -catenin during murine limb patterning

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Versican expression during skeletal/joint morphogenesis and patterning of muscle and nerve in the embryonic mouse limb

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Alterations in hyaluronan synthesis during developing joint cavitation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Proteolytic cleavage of versican during limb joint development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Selective activation of the MEK-ERK pathway is regulated by mechanical stimuli in forming joints and promotes pericellular matrix formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Defining boundaries during joint cavity formation: going out on a limb

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

A specific mechanomodulatory role for p38 MAPK in embryonic joint articular surface cell MEK-ERK pathway regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

The surface of articular cartilage contains a progenitor cell population

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Identification and clonal characterisation of a progenitor cell sub-population in normal human articular cartilage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Fetal growth plate: a developmental model of cellular adaptation to hypoxia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Premature arthritis is a distinct type II collagen phenotype.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Relationship between joint shape and the development of osteoarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Developmental regulation of the growth plate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Physiology and pathophysiology of the growth plate

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Transcriptional regulation of chondrocyte maturation: potential involvement of transcription factors in OA pathogenesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Essential role of hypertrophic chondrocytes in endochondral bone development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Distribution of type X collagen mRNA in normal and osteoarthritic human cartilage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Chondrocyte differentiation in human osteoarthritis: expression of osteocalcin in normal and osteoarthritic cartilage and bone

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory stimuli

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Global analyses of gene expression in early experimental osteoarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Calcification of articular cartilage in human osteoarthritis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Age-dependent alteration of TGF-β signalling in osteoarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Distinct transglutaminase 2-independent and transglutaminase 2-dependent pathways mediate articular chondrocyte hypertrophy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

IL-8/CXCL8 and growth-related oncogene alpha/CXCL1 induce chondrocyte hypertrophic differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

MAP kinases in chondrocyte differentiation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Hedgehog signaling in skeletal development

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Modulating hedgehog signaling can attenuate the severity of osteoarthritis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Chondrocyte hypertrophy can be induced by a cryptic sequence of type II collagen and is accompanied by the induction of MMP-13 and collagenase activity: Implications for development and arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

C/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Replication studies in various ethnic populations do not support the association of the HIF-2α SNP rs17039192 with knee osteoarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.129

Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions.

31 March 2020

1 reference

12 December 2020

An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression

1 reference

12 December 2020

The formation of human synovial joint cavities: a possible role for hyaluronan and CD44 in altered interzone cohesion.

1 reference

12 December 2020

Dual roles of Wnt signaling during chondrogenesis in the chicken limb

1 reference

12 December 2020

An analysis of the condensation process during chondrogenesis in the embryonic chick hind limb

1 reference

12 December 2020

The biosynthetic response of the mature chondrocyte in early osteoarthritis

1 reference

12 December 2020

1 reference

12 December 2020

Roles of FGF-10 on the development of diathrodial limb joints

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12 December 2020

Axin2 regulates chondrocyte maturation and axial skeletal development

1 reference

12 December 2020

Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth.

1 reference

12 December 2020

Matrix metalloproteinases in the formation of human synovial joint cavities

1 reference

12 December 2020

Endochondral ossification signals in cartilage degradation during osteoarthritis progression in experimental mouse models.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRRHEUM.2011.129

1 reference

PubMed ID

21947178

Dimensions Publication ID

25 August 2017

0 references

1 reference

PubMed ID

21947178