Microglial cell origin and phenotypes in health and disease (Q37949246)

25 August 2017

Microglial cell origin and phenotypes in health and disease (English)

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25 August 2017

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Kaoru Saijo

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PubMed ID

22025055

25 August 2017

Christopher K Glass

series ordinal

2

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25 August 2017

25 October 2011

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Nature Reviews Immunology

25 August 2017

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25 August 2017

11

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25 August 2017

775-787

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25 August 2017

11

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25 August 2017

Physiology of microglia

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Microglial physiology: unique stimuli, specialized responses

31 March 2020

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Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain

31 March 2020

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Mechanisms underlying inflammation in neurodegeneration

31 March 2020

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Microglia in neurodegenerative disease

31 March 2020

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An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation

31 March 2020

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Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis

31 March 2020

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Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice

31 March 2020

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Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment.

31 March 2020

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Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo

31 March 2020

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Microgliosis: the questions shape the answers

31 March 2020

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Migration of enhanced green fluorescent protein expressing bone marrow-derived microglia/macrophage into the mouse brain following permanent focal ischemia

31 March 2020

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Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease.

31 March 2020

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Local self-renewal can sustain CNS microglia maintenance and function throughout adult life.

31 March 2020

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Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions.

31 March 2020

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Fate mapping analysis reveals that adult microglia derive from primitive macrophages

31 March 2020

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Cell tracing shows the contribution of the yolk sac to adult haematopoiesis.

31 March 2020

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Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease.

31 March 2020

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CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

31 March 2020

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Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool.

31 March 2020

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Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts

31 March 2020

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Epidemiology of Alzheimer disease

31 March 2020

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Turnover of resident microglia in the normal adult mouse brain

31 March 2020

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Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network

31 March 2020

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Microglia and neuroprotection: from in vitro studies to therapeutic applications

31 March 2020

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Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons

31 March 2020

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Disease-specific induced pluripotent stem cells

31 March 2020

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Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations

31 March 2020

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Generation of microglial cells from mouse embryonic stem cells.

31 March 2020

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Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

31 March 2020

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Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS

31 March 2020

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Alternative activation of macrophages: an immunologic functional perspective

31 March 2020

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Alternative macrophage activation and metabolism

31 March 2020

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Macrophages, inflammation, and insulin resistance

31 March 2020

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Macrophage polarization in tumour progression

31 March 2020

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Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

31 March 2020

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Microglial control of neuronal death and synaptic properties

31 March 2020

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Synaptic pruning by microglia is necessary for normal brain development

31 March 2020

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Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis

31 March 2020

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Control of microglial neurotoxicity by the fractalkine receptor

31 March 2020

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Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

31 March 2020

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The myeloid cells of the central nervous system parenchyma

31 March 2020

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Cutting Edge: TREM-2 Attenuates Macrophage Activation

31 March 2020

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Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12.

31 March 2020

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Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype

31 March 2020

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Sterile inflammation: sensing and reacting to damage

31 March 2020

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Immunity, Inflammation, and Cancer

31 March 2020

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Macrophage diversity enhances tumor progression and metastasis

31 March 2020

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The brain tumor microenvironment.

31 March 2020

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Microglial action in glioma: a boon turns bane

31 March 2020

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IL-10 and TGF-β2 are overexpressed in tumor spheres cultured from human gliomas.

31 March 2020

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Glioma cancer stem cells induce immunosuppressive macrophages/microglia

31 March 2020

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Inflammatory leukocytes associated with increased immunosuppression by glioblastoma

31 March 2020

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Glioma-associated cancer-initiating cells induce immunosuppression

31 March 2020

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Myeloid-derived suppressor cells as regulators of the immune system

31 March 2020

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Myeloid-derived suppressor cells: linking inflammation and cancer

31 March 2020

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The role of microglia in central nervous system immunity and glioma immunology

31 March 2020

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Microglia stimulate the invasiveness of glioma cells by increasing the activity of metalloprotease-2.

31 March 2020

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Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion

31 March 2020

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ATP mediates rapid microglial response to local brain injury in vivo

31 March 2020

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Regulation and function of class II major histocompatibility complex, CD40, and B7 expression in macrophages and microglia: Implications in neurological diseases

31 March 2020

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A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death

31 March 2020

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Regulation of tau pathology by the microglial fractalkine receptor

31 March 2020

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25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production

31 March 2020

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HMG-1 as a late mediator of endotoxin lethality in mice

31 March 2020

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Extracellular histones are major mediators of death in sepsis

31 March 2020

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Caspase signalling controls microglia activation and neurotoxicity.

31 March 2020

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The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

31 March 2020

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Amyloid-beta oligomers set fire to inflammasomes and induce Alzheimer's pathology

31 March 2020

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HMGB1 and RAGE in inflammation and cancer

31 March 2020

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Purinergic systems in microglia

31 March 2020

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Immune cell regulation by autocrine purinergic signalling

31 March 2020

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UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis

31 March 2020

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ALS: focus on purinergic signalling.

31 March 2020

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Mini-review: The nuclear protein HMGB1 as a proinflammatory mediator

31 March 2020

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RAGE and Alzheimer's disease: a progression factor for amyloid-beta-induced cellular perturbation?

31 March 2020

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The immune system in atherosclerosis

31 March 2020

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Therapeutic approaches to target inflammation in type 2 diabetes

31 March 2020

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Nuclear receptors, inflammation, and neurodegenerative diseases

31 March 2020

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Staging of brain pathology related to sporadic Parkinson's disease

31 March 2020

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Neuroinflammation in Parkinson's disease: a target for neuroprotection?

31 March 2020

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The lipopolysaccharide Parkinson's disease animal model: mechanistic studies and drug discovery

31 March 2020

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Immunological features of alpha-synuclein in Parkinson's disease

31 March 2020

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Association of the RAGE G82S polymorphism with Alzheimer's disease

31 March 2020

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Association between the RAGE G82S polymorphism and Alzheimer's disease

31 March 2020

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The role of microglia in amyloid clearance from the AD brain

31 March 2020

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Phagocytic clearance in neurodegeneration

31 March 2020

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Apolipoprotein E in Alzheimer's disease and other neurological disorders

31 March 2020

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Inflammation and Alzheimer's disease: possible role of periodontal diseases

31 March 2020

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Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper

31 March 2020

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Inflammation and NF-kappaB in Alzheimer's disease and diabetes.

31 March 2020

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Common pathological processes and transcriptional pathways in Alzheimer's disease and type 2 diabetes

31 March 2020

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

31 March 2020

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Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

31 March 2020

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Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

31 March 2020

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Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

31 March 2020

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HIV infection, inflammation, immunosenescence, and aging

31 March 2020

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31 March 2020

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Breaking down the barrier: the effects of HIV-1 on the blood-brain barrier.

31 March 2020

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Current understanding of HIV-associated neurocognitive disorders pathogenesis

31 March 2020

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CNS inflammation and macrophage/microglial biology associated with HIV-1 infection.

31 March 2020

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HIV, antiretroviral therapies, and the brain

31 March 2020

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31 March 2020

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An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation

31 March 2020

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Dehydroepiandrosterone (DHEA) metabolism in the brain: identification by liquid chromatography/mass spectrometry of the delta-4-isomer of DHEA and related steroids formed from androstenedione by mouse BV2 microglia.

31 March 2020

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Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta

31 March 2020

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A translational profiling approach for the molecular characterization of CNS cell types

31 March 2020

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Intracellular toll-like receptors

31 March 2020

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Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

31 March 2020

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Signalling of toll-like receptors.

31 March 2020

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Pathogen recognition by the innate immune system

31 March 2020

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Nucleic acid recognition by the innate immune system

31 March 2020

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The inflammasome NLRs in immunity, inflammation, and associated diseases

31 March 2020

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31 March 2020

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Molecular mechanism of NLRP3 inflammasome activation

31 March 2020

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Inflammasomes: current understanding and open questions

31 March 2020

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Macrophages and the Nervous System

31 March 2020

1 reference

12 December 2020

Human glioma-induced immunosuppression involves soluble factor(s) that alters monocyte cytokine profile and surface markers

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12 December 2020

Toll-like receptors in Alzheimer's disease

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12 December 2020

Microglia and the Process of Phagocytosis in Gliomas.

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12 December 2020

Identifiers

DOI

10.1038/NRI3086

1 reference

25 August 2017

1 reference

PubMed ID

22025055