Inflammasomes: current understanding and open questions (Q37808975)

23 August 2017

Inflammasomes: current understanding and open questions (English)

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23 August 2017

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3

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Jonathan Schmid-Burgk

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Veit Hornung

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Andrea Ablasser

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object named as

Andrea Ablasser

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23 August 2017

Franz Bauernfeind

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23 August 2017

Sarah Kim

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23 August 2017

Taner Cavlar

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23 August 2017

language of work or name

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31 October 2010

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Cellular and Molecular Life Sciences

23 August 2017

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23 August 2017

68

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23 August 2017

765-783

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23 August 2017

5

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https://scigraph.springernature.com/pub.10.1007/s00018-010-0567-4

23 August 2017

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cites work

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

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12 December 2020

Intracellular DNA recognition

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12 December 2020

Inflammasome recognition of influenza virus is essential for adaptive immune responses

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12 December 2020

Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid

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12 December 2020

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

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12 December 2020

Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity

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12 December 2020

Innate immune detection of bacterial virulence factors via the NLRC4 inflammasome

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12 December 2020

Malarial hemozoin is a Nalp3 inflammasome activating danger signal

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12 December 2020

Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling

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12 December 2020

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

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12 December 2020

A Toll-like receptor recognizes bacterial DNA

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12 December 2020

The Ifi 200 genes: an emerging family of IFN-inducible genes.

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12 December 2020

Engagement of NOD2 has a dual effect on proIL-1beta mRNA transcription and secretion of bioactive IL-1beta

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12 December 2020

Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cells

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12 December 2020

The HIN-200 family: more than interferon-inducible genes?

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12 December 2020

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors

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12 December 2020

Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

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12 December 2020

MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals

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12 December 2020

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

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12 December 2020

Interleukin-33 is biologically active independently of caspase-1 cleavage

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12 December 2020

The leucine-rich repeat structure.

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12 December 2020

Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection

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12 December 2020

Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling

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12 December 2020

Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations

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12 December 2020

A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock

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12 December 2020

Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.

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12 December 2020

The role of potassium in inflammasome activation by bacteria

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12 December 2020

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf

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12 December 2020

The Nalp3 inflammasome is essential for the development of silicosis

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12 December 2020

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

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12 December 2020

The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.

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12 December 2020

Influenza virus activates inflammasomes via its intracellular M2 ion channel

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12 December 2020

Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.

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12 December 2020

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

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12 December 2020

Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition

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12 December 2020

Gout-associated uric acid crystals activate the NALP3 inflammasome

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12 December 2020

Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome

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12 December 2020

Increased interleukin-6 and granulocyte-macrophage colony stimulating factor levels in the sera of patients with non-segmental vitiligo

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12 December 2020

Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

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12 December 2020

Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3.

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12 December 2020

PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B

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12 December 2020

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

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12 December 2020

Structure and mechanism of interleukin-1 beta converting enzyme

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12 December 2020

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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12 December 2020

Genetic variations in NALP1 are associated with generalized vitiligo in a Romanian population

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12 December 2020

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

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12 December 2020

Alum adjuvanticity: unraveling a century old mystery

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12 December 2020

Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival

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12 December 2020

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

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12 December 2020

Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation

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12 December 2020

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome

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12 December 2020

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

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12 December 2020

Initial description of the human NLRP3 promoter

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12 December 2020

Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor

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12 December 2020

Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

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12 December 2020

Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity

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12 December 2020

NALP1 in vitiligo-associated multiple autoimmune disease

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12 December 2020

Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome

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12 December 2020

Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages

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12 December 2020

Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1

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12 December 2020

An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans

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12 December 2020

Oxidative innate immune defenses by Nox/Duox family NADPH oxidases

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12 December 2020

A 3'UTR SNP in NLRP3 gene is associated with susceptibility to HIV-1 infection

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12 December 2020

The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation

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12 December 2020

Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor

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12 December 2020

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

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12 December 2020

Mechanism of Bcl-2 and Bcl-X(L) inhibition of NLRP1 inflammasome: loop domain-dependent suppression of ATP binding and oligomerization

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12 December 2020

Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation

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12 December 2020

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

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12 December 2020

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

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12 December 2020

Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages

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12 December 2020

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

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12 December 2020

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide

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12 December 2020

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

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12 December 2020

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way

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12 December 2020

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

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12 December 2020

Evaluation of Nod-like receptor (NLR) effector domain interactions

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12 December 2020

T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes.

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12 December 2020

Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome

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12 December 2020

CARDINAL roles in apoptosis and NFkappaB activation

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12 December 2020

Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes

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12 December 2020

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity

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12 December 2020

A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome

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12 December 2020

Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases

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12 December 2020

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

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12 December 2020

Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta, depending on listeriolysin O and NLRP3.

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12 December 2020

Immunological and inflammatory functions of the interleukin-1 family

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12 December 2020

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production

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12 December 2020

The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1

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12 December 2020

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

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12 December 2020

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

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12 December 2020

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

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12 December 2020

Pyroptosis: host cell death and inflammation

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12 December 2020

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

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12 December 2020

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

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12 December 2020

Cryopyrin activates the inflammasome in response to toxins and ATP

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12 December 2020

p202 self-associates through a sequence conserved among the members of the 200-family proteins

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12 December 2020

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

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12 December 2020

The inflammasomes: guardians of the body

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12 December 2020

Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome

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12 December 2020

Promotion of B cell immune responses via an alum-induced myeloid cell population.

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12 December 2020

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

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12 December 2020

Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA

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12 December 2020

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

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12 December 2020

Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes

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12 December 2020

ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules

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12 December 2020

New insights into the functions of anthrax toxin

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12 December 2020

Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome.

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12 December 2020

Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome

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12 December 2020

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

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12 December 2020

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

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12 December 2020

Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.

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12 December 2020

Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages

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12 December 2020

The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

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12 December 2020

IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo

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12 December 2020

Role of aluminum-containing adjuvants in antigen internalization by dendritic cells in vitro.

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12 December 2020

Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation

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12 December 2020

Rapid secretion of interleukin-1beta by microvesicle shedding

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12 December 2020

Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages

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12 December 2020

ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages

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12 December 2020

Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

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12 December 2020

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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12 December 2020

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

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12 December 2020

NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury

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12 December 2020

The NLR gene family: a standard nomenclature

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12 December 2020

Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*)

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12 December 2020

Proteasomes control caspase-1 activation in anthrax lethal toxin-mediated cell killing.

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12 December 2020

Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU

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12 December 2020

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

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12 December 2020

Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1

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12 December 2020

Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling

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12 December 2020

Interferon-inducible Ifi200-family genes in systemic lupus erythematosus

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12 December 2020

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis

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12 December 2020

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

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12 December 2020

HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA

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12 December 2020

Pseudomonas aeruginosa activates caspase 1 through Ipaf

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12 December 2020

Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

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12 December 2020

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

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12 December 2020

Immunology: Toll-like receptors and antibody responses

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12 December 2020

Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity

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12 December 2020

10.1007/S00018-010-0567-4

Identifiers

DOI

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23 August 2017

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