Transcriptional control of embryonic and induced pluripotent stem cells (Q37961880)

26 August 2017

Transcriptional control of embryonic and induced pluripotent stem cells (English)

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26 August 2017

Matthew G Guenther

1

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26 August 2017

1 June 2011

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26 August 2017

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26 August 2017

3

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26 August 2017

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26 August 2017

323-343

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Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming

26 August 2017

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The transcriptional network controlling pluripotency in ES cells

21 January 2018

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Epigenetic reprogramming and induced pluripotency

21 January 2018

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Transcriptional regulatory networks in embryonic stem cells

21 January 2018

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The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription

21 January 2018

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A census of human transcription factors: function, expression and evolution

21 January 2018

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Hox genes and regional patterning of the vertebrate body plan

21 January 2018

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Defining mechanisms that regulate RNA polymerase II transcription in vivo

21 January 2018

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The role of chromatin during transcription

21 January 2018

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Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response

21 January 2018

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21 January 2018

Capturing pluripotency

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Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

21 January 2018

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Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4

21 January 2018

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A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo

21 January 2018

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New type of POU domain in germ line-specific protein Oct-4

21 January 2018

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A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells

21 January 2018

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Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation

21 January 2018

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Self-renewal of teratocarcinoma and embryonic stem cells.

21 January 2018

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The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells

21 January 2018

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Multipotent cell lineages in early mouse development depend on SOX2 function

21 January 2018

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Modulation of the activity of multiple transcriptional activation domains by the DNA binding domains mediates the synergistic action of Sox2 and Oct-3 on the fibroblast growth factor-4 enhancer

21 January 2018

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Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells.

21 January 2018

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Nanog safeguards pluripotency and mediates germline development

21 January 2018

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Nanog is the gateway to the pluripotent ground state.

21 January 2018

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Core transcriptional regulatory circuitry in human embryonic stem cells

21 January 2018

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The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

21 January 2018

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Autoregulation and maturity onset diabetes of the young transcription factors control the human PAX4 promoter

21 January 2018

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Autoregulation of the human liver X receptor alpha promoter

21 January 2018

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Positive autoregulation of the myogenic determination gene MyoD1.

21 January 2018

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Transcriptional autoregulatory loops are highly conserved in vertebrate evolution

21 January 2018

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Core transcriptional regulatory circuitry in human hepatocytes

21 January 2018

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Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells

21 January 2018

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Integration of external signaling pathways with the core transcriptional network in embryonic stem cells

21 January 2018

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Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells

21 January 2018

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Dissecting Oct3/4-regulated gene networks in embryonic stem cells by expression profiling

21 January 2018

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Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data.

21 January 2018

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Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1

21 January 2018

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Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells

21 January 2018

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Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages.

21 January 2018

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Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells

21 January 2018

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An extended transcriptional network for pluripotency of embryonic stem cells

21 January 2018

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Dissecting self-renewal in stem cells with RNA interference

21 January 2018

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Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells

21 January 2018

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A core Klf circuitry regulates self-renewal of embryonic stem cells.

21 January 2018

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T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways

21 January 2018

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Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells

21 January 2018

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Embryo-derived stem cells: of mice and men.

21 January 2018

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Intracellular signaling pathways regulating pluripotency of embryonic stem cells

21 January 2018

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Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

21 January 2018

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Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

21 January 2018

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BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3

21 January 2018

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Tgfbeta signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc

21 January 2018

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Promotion of reprogramming to ground state pluripotency by signal inhibition

21 January 2018

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A chromatin landmark and transcription initiation at most promoters in human cells

21 January 2018

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RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo

21 January 2018

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c-Myc regulates transcriptional pause release

21 January 2018

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RNA polymerase is poised for activation across the genome

21 January 2018

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The complex language of chromatin regulation during transcription

21 January 2018

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Chromatin modifications and their function

21 January 2018

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Control of developmental regulators by Polycomb in human embryonic stem cells

21 January 2018

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High-resolution profiling of histone methylations in the human genome

21 January 2018

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Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells

21 January 2018

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

21 January 2018

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Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells

21 January 2018

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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

21 January 2018

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Dissecting direct reprogramming through integrative genomic analysis

21 January 2018

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The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes

21 January 2018

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Operating on chromatin, a colorful language where context matters

21 January 2018

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An expanded Oct4 interaction network: implications for stem cell biology, development, and disease

21 January 2018

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An Oct4-centered protein interaction network in embryonic stem cells

21 January 2018

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Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal

21 January 2018

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The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

21 January 2018

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Eloquent silence: developmental functions of Class I histone deacetylases

21 January 2018

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An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity.

21 January 2018

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Critical roles of coactivator p300 in mouse embryonic stem cell differentiation and Nanog expression

21 January 2018

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A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity.

21 January 2018

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ChIP-seq accurately predicts tissue-specific activity of enhancers

21 January 2018

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A unique chromatin signature uncovers early developmental enhancers in humans

21 January 2018

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Histone H3K27ac separates active from poised enhancers and predicts developmental state

21 January 2018

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Histone modifications at human enhancers reflect global cell-type-specific gene expression

21 January 2018

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Sall4 is essential for stabilization, but not for pluripotency, of embryonic stem cells by repressing aberrant trophectoderm gene expression

21 January 2018

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Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex

21 January 2018

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A conserved 12-amino acid motif in Sall1 recruits the nucleosome remodeling and deacetylase corepressor complex

21 January 2018

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The NuRD component Mbd3 is required for pluripotency of embryonic stem cells

21 January 2018

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Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells

21 January 2018

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Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans

21 January 2018

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Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation

21 January 2018

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Stem cell regulation by polycomb repressors: postponing commitment

21 January 2018

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Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice

21 January 2018

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A gene complex controlling segmentation in Drosophila

21 January 2018

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Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryos

21 January 2018

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Polycomb complexes and epigenetic states

21 January 2018

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Polycomb group complexes--many combinations, many functions

21 January 2018

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Polycomb complexes act redundantly to repress genomic repeats and genes

21 January 2018

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The polycomb-group gene Ezh2 is required for early mouse development

21 January 2018

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The mouse PcG gene eed is required for Hox gene repression and extraembryonic development.

21 January 2018

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Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition

21 January 2018

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Role of histone H3 lysine 27 methylation in Polycomb-group silencing

21 January 2018

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SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex

21 January 2018

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Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites

21 January 2018

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Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.

21 January 2018

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Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

21 January 2018

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Histone methyltransferase activity of a Drosophila Polycomb group repressor complex

21 January 2018

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Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation

21 January 2018

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Role of histone H2A ubiquitination in Polycomb silencing

21 January 2018

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Polycomb group proteins set the stage for early lineage commitment

21 January 2018

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Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells

21 January 2018

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JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

21 January 2018

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Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells

21 January 2018

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Jarid2 and PRC2, partners in regulating gene expression

21 January 2018

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Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.

21 January 2018

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Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2.

21 January 2018

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Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome

21 January 2018

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Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation

21 January 2018

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General transcription factors bind promoters repressed by Polycomb group proteins.

21 January 2018

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Histone H3 lysine 4 methylation patterns in higher eukaryotic genes

21 January 2018

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Global analysis of mRNA decay and abundance in Escherichia coli at single-gene resolution using two-color fluorescent DNA microarrays

21 January 2018

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Active genes are tri-methylated at K4 of histone H3

21 January 2018

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Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity

21 January 2018

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Global and Hox-specific roles for the MLL1 methyltransferase

21 January 2018

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Molecular characterization of the trithorax gene, a positive regulator of homeotic gene expression in Drosophila

21 January 2018

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Histone H3 lysine 4 (H3K4) methylation in development and differentiation

21 January 2018

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Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

21 January 2018

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The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation

21 January 2018

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COMPASS: a complex of proteins associated with a trithorax-related SET domain protein

21 January 2018

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Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation

21 January 2018

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A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity

21 January 2018

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SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state

21 January 2018

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A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal

21 January 2018

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Mediator and cohesin connect gene expression and chromatin architecture

21 January 2018

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Cohesin: its roles and mechanisms

21 January 2018

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Condensin and cohesin complexity: the expanding repertoire of functions

21 January 2018

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Cornelia de Lange syndrome, cohesin, and beyond

21 January 2018

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The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

21 January 2018

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Chromatin remodelling during development

21 January 2018

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The biology of chromatin remodeling complexes

21 January 2018

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Maternal BRG1 regulates zygotic genome activation in the mouse

21 January 2018

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ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a

21 January 2018

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Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice

21 January 2018

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Srg3, a mouse homolog of yeast SWI3, is essential for early embryogenesis and involved in brain development

21 January 2018

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Baf60c is essential for function of BAF chromatin remodelling complexes in heart development

21 January 2018

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The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression

21 January 2018

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An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network.

21 January 2018

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Chromatin regulatory mechanisms in pluripotency

21 January 2018

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Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming

21 January 2018

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Genomic maps and comparative analysis of histone modifications in human and mouse

21 January 2018

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Polycomb complexes repress developmental regulators in murine embryonic stem cells

21 January 2018

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Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

21 January 2018

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21 January 2018

The mammalian epigenome

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Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

21 January 2018

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Differential chromatin marking of introns and expressed exons by H3K36me3.

21 January 2018

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Nucleosomes are well positioned in exons and carry characteristic histone modifications

21 January 2018

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Nucleosome positioning as a determinant of exon recognition

21 January 2018

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Regulation of alternative splicing by histone modifications

21 January 2018

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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

21 January 2018

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Chromatin signatures of pluripotent cell lines

21 January 2018

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Heterochromatin revisited

21 January 2018

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ERG-associated protein with SET domain (ESET)-Oct4 interaction regulates pluripotency and represses the trophectoderm lineage

21 January 2018

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Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells

21 January 2018

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KAP1 controls endogenous retroviruses in embryonic stem cells

21 January 2018

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Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET.

21 January 2018

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G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

21 January 2018

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Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin

21 January 2018

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Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment

21 January 2018

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Structure and function of the interferon-beta enhanceosome

21 January 2018

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Transcription regulation and animal diversity

21 January 2018

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Functional and mechanistic diversity of distal transcription enhancers

21 January 2018

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Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line

21 January 2018

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Genomic DNA methylation: the mark and its mediators

21 January 2018

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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

21 January 2018

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CpG islands--'a rough guide'.

21 January 2018

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DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

21 January 2018

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CpG islands influence chromatin structure via the CpG-binding protein Cfp1.

21 January 2018

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Human DNA methylomes at base resolution show widespread epigenomic differences

21 January 2018

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Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation

21 January 2018

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Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes

21 January 2018

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A novel CpG island set identifies tissue-specific methylation at developmental gene loci

21 January 2018

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Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors.

21 January 2018

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Long noncoding RNAs: functional surprises from the RNA world

21 January 2018

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Noncoding RNAs and gene silencing

21 January 2018

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Long non-coding RNAs: insights into functions

21 January 2018

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Non-coding RNAs as regulators of embryogenesis

21 January 2018

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MicroRNAs: target recognition and regulatory functions

21 January 2018

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Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

21 January 2018

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Characterization of Dicer-deficient murine embryonic stem cells.

21 January 2018

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DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal

21 January 2018

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Embryonic stem cell-specific miR302-367 cluster: human gene structure and functional characterization of its core promoter

21 January 2018

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Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells

21 January 2018

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MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells

21 January 2018

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A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases

21 January 2018

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MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation

21 January 2018

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MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells

21 January 2018

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Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs

21 January 2018

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Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation

21 January 2018

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Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a

21 January 2018

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Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

21 January 2018

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Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

21 January 2018

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Long noncoding RNA as modular scaffold of histone modification complexes

21 January 2018

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Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters

21 January 2018

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The antisense transcriptomes of human cells

21 January 2018

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Divergent transcription from active promoters

21 January 2018

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Transcription. Repressive transcription

21 January 2018

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

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Nuclear reprogramming to a pluripotent state by three approaches

21 January 2018

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Technical challenges in using human induced pluripotent stem cells to model disease

21 January 2018

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Progress toward the clinical application of patient-specific pluripotent stem cells

21 January 2018

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Pluripotency: toward a gold standard for human ES and iPS cells

21 January 2018

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Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues

21 January 2018

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Generation of germline-competent induced pluripotent stem cells

21 January 2018

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iPS cells can support full-term development of tetraploid blastocyst-complemented embryos

21 January 2018

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Adult mice generated from induced pluripotent stem cells

21 January 2018

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In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

21 January 2018

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iPS cells produce viable mice through tetraploid complementation

21 January 2018

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Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency

21 January 2018

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Hemangioblastic derivatives from human induced pluripotent stem cells exhibit limited expansion and early senescence

21 January 2018

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Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts

21 January 2018

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Induced pluripotent stem cell lines derived from human somatic cells

21 January 2018

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c-Myc is dispensable for direct reprogramming of mouse fibroblasts.

21 January 2018

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Induced pluripotency: history, mechanisms, and applications

21 January 2018

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Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds

21 January 2018

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A drug-inducible system for direct reprogramming of human somatic cells to pluripotency

21 January 2018

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A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types

21 January 2018

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A high-efficiency system for the generation and study of human induced pluripotent stem cells

21 January 2018

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Role of the murine reprogramming factors in the induction of pluripotency

21 January 2018

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Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

21 January 2018

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Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2

21 January 2018

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Wnt signaling promotes reprogramming of somatic cells to pluripotency

21 January 2018

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Embryonic stem cell-specific microRNAs promote induced pluripotency

21 January 2018

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Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells

21 January 2018

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Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures

21 January 2018

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Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells

21 January 2018

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Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors

21 January 2018

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A unique developmental pattern of Oct-3/4 DNA methylation is controlled by a cis-demodification element

21 January 2018

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DNA methylation represses transcription in vivo.

21 January 2018

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Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency.

21 January 2018

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Reprogramming towards pluripotency requires AID-dependent DNA demethylation

21 January 2018

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Epigenetic memory in induced pluripotent stem cells

21 January 2018

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Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

21 January 2018

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Variation in the safety of induced pluripotent stem cell lines

21 January 2018

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Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

21 January 2018

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Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines

21 January 2018

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MicroRNA profiling of human-induced pluripotent stem cells

21 January 2018

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Transcriptional signature and memory retention of human-induced pluripotent stem cells

21 January 2018

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Molecular analyses of human induced pluripotent stem cells and embryonic stem cells

21 January 2018

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Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells

21 January 2018

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Lab-specific gene expression signatures in pluripotent stem cells

21 January 2018

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Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells

21 January 2018

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Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells

21 January 2018

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Molecular signals of epigenetic states

21 January 2018

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An operational definition of epigenetics

21 January 2018

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Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations.

21 January 2018

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PGC7/Stella protects against DNA demethylation in early embryogenesis

21 January 2018

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A heterogeneous expression pattern for Nanog in embryonic stem cells

21 January 2018

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Heterogeneity of embryonic and adult stem cells

21 January 2018

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Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states

21 January 2018

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The ground state of pluripotency.

21 January 2018

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Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells

21 January 2018

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Chromatin organization marks exon-intron structure

21 January 2018

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The Nuclear Receptor Nr5a2 Can Replace Oct4 in the Reprogramming of Murine Somatic Cells to Pluripotent Cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/EPI.11.15

1 reference

26 August 2017

1 reference

PubMed ID

22122341