Copper complexes as therapeutic agents (Q37970312)

26 August 2017

title

Copper complexes as therapeutic agents (English)

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26 August 2017

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Clare Duncan

1

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26 August 2017

Anthony R White

series ordinal

2

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26 August 2017

publication date

20 December 2011

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26 August 2017

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26 August 2017

volume

4

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26 August 2017

issue

2

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26 August 2017

page(s)

127-138

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Cellular copper transport and metabolism

26 August 2017

cites work

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Ctr1 and its role in body copper homeostasis.

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Immunocytochemical localization of the Menkes copper transport protein (ATP7A) to the trans-Golgi network

21 January 2018

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Copper-induced apical trafficking of ATP7B in polarized hepatoma cells provides a mechanism for biliary copper excretion

21 January 2018

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Copper accumulation and compartmentalization in mouse fibroblast lacking metallothionein and copper chaperone, Atox1.

21 January 2018

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The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis

21 January 2018

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ATP7A (Menkes protein) functions in axonal targeting and synaptogenesis

21 January 2018

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Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity

21 January 2018

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Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitability

21 January 2018

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Biphasic effects of copper on neurotransmission in rat hippocampal neurons.

21 January 2018

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The toxicology of Clioquinol

21 January 2018

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The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice

21 January 2018

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Treatment of Wilson disease with ammonium tetrathiomolybdate: IV. Comparison of tetrathiomolybdate and trientine in a double-blind study of treatment of the neurologic presentation of Wilson disease

21 January 2018

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Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells

21 January 2018

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Clioquinol, a drug for Alzheimer's disease specifically interfering with brain metal metabolism: structural characterization of its zinc(II) and copper(II) complexes

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2MT00174H

Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

21 January 2018

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Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

21 January 2018

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Potent anticancer activity of pyrrolidine dithiocarbamate-copper complex against cisplatin-resistant neuroblastoma cells.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2MT00174H

Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2MT00174H

Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden

21 January 2018

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Wilson's disease: assessment of D-penicillamine treatment

21 January 2018

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Chelators at the cancer coalface: desferrioxamine to Triapine and beyond.

21 January 2018

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The wide pharmacological versatility of semicarbazones, thiosemicarba-zones and their metal complexes.

21 January 2018

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Copper bis(thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2MT00174H

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Copper complexes of bis(thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2MT00174H

21 January 2018

Global cancer statistics

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https://api.crossref.org/works/10.1039%2FC2MT00174H

Transition metal based anticancer drugs.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2MT00174H

Drug discovery in the ubiquitin-proteasome system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Clioquinol - a novel copper-dependent and independent proteasome inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Metal ionophores - an emerging class of anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Clioquinol, a therapeutic agent for Alzheimer's disease, has proteasome-inhibitory, androgen receptor-suppressing, apoptosis-inducing, and antitumor activities in human prostate cancer cells and xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Metal complexes of retinoid derivatives with antiproliferative activity: synthesis, characterization and DNA interaction studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Cu-ATSM: a radiopharmaceutical for the PET imaging of hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Copper-64-diacetyl-bis(N4-methylthiosemicarbazone): An agent for radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Evaluation of a Schiff base copper complex compound as potent anticancer molecule with multiple targets of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Novel Schiff base copper complexes of quinoline-2 carboxaldehyde as proteasome inhibitors in human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Cytotoxicity of salicylaldehyde benzoylhydrazone analogs and their transition metal complexes: quantitative structure-activity relationships.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Novel complex of copper and a salicylaldehyde pyrazole hydrazone derivative induces apoptosis through up-regulating integrin beta 4 in vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Copper-doxorubicin as a nanoparticle cargo retains efficacy with minimal toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Pathways towards and away from Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Copper, iron and zinc in Alzheimer's disease senile plaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Iron, zinc and copper in the Alzheimer's disease brain: a quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative diseases affecting the basal ganglia. The Royal Kings and Queens Parkinson's Disease Research Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Cerebral bioimaging of Cu, Fe, Zn, and Mn in the MPTP mouse model of Parkinson's disease using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Neuroprotective effect of acute and chronic administration of copper (II) sulfate against MPP+ neurotoxicity in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Copper reduces striatal protein nitration and tyrosine hydroxylase inactivation induced by MPP+ in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Diethyldithiocarbamate potentiates the neurotoxicity of in vivo 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and of in vitro 1-methyl-4-phenylpyridinium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Iron and copper metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Mechanisms of copper ion mediated Huntington's disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Metallothioneins and copper metabolism are candidate therapeutic targets in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Huntington's disease: From molecular basis to therapeutic advances

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Ammonium tetrathiomolybdate delays onset, prolongs survival, and slows progression of disease in a mouse model for amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Investigation of a Cu(II)-poly(gamma-glutamic acid) complex in aqueous solution and its insulin-mimetic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Beneficial effect of supplementation with copper sulfate on STZ-diabetic mice (IDDM).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Serum copper and related variables in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Superoxide-dismutase deficiency in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Nonsteroidal antiinflammatory drugs--differences and similarities

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Gastrointestinal toxicity, antiinflammatory activity, and superoxide dismutase activity of copper and zinc complexes of the antiinflammatory drug indomethacin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Is copper pro- or anti-inflammatory? A reconciling view and a novel approach for the use of copper in the control of inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation-associated cachexia in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Atherosclerosis — An Inflammatory Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Measurement of copper-binding sites on low density lipoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Increased cholesterol in plasma in a young man during experimental copper depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Dietary copper supplements modulate aortic superoxide dismutase, nitric oxide and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Improvement of aging-associated cardiovascular dysfunction by the orally administered copper(II)-aspirinate complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Effects of a single exposure to UVB radiation on the activities and protein levels of copper-zinc and manganese superoxide dismutase in cultured human keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Suppressive effect of orally administered copper(II)-aspirinate (Cu2(asp)4) complex on the generation of reactive oxygen species in the skin of animals subjected to UVA exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

In vitro modulation of keratinocyte wound healing integrins by zinc, copper and manganese

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Evaluation of the effects of topical tripeptide-copper complex and zinc oxide on open-wound healing in rabbits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Synthesis, characterization and evaluation of antileishmanial activity of copper(II) with fluorinated α-hydroxycarboxylate ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Metalloantimalarials: Synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Risk of upper gastrointestinal bleeding and perforation associated with Individual non-steroidal anti-inflammatory drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Preclinical perspectives on platinum resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

Synthesis and characterization of copper(II) complexes of pyridine-2-carboxamidrazones as potent antimalarial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT00174H

21 January 2018

Identifiers

DOI

10.1039/C2MT00174H

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26 August 2017

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