MC4R dimerization in the paraventricular nucleus and GHSR/MC3R heterodimerization in the arcuate nucleus: is there relevance for body weight regulation? (Q37983474)

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scientific article published on 08 February 2012

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English	MC4R dimerization in the paraventricular nucleus and GHSR/MC3R heterodimerization in the arcuate nucleus: is there relevance for body weight regulation?	scientific article published on 08 February 2012

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scholarly article

1 reference

Europe PubMed Central

26 August 2017

MC4R dimerization in the paraventricular nucleus and GHSR/MC3R heterodimerization in the arcuate nucleus: is there relevance for body weight regulation? (English)

1 reference

Europe PubMed Central

26 August 2017

protein heterodimerization activity

1 reference

based on heuristic

inferred from title

Matthias Tschöp

6

object named as

Matthias H Tschöp

1 reference

Europe PubMed Central

26 August 2017

author name string

Anne Rediger

1

1 reference

Europe PubMed Central

26 August 2017

Carolin Leonie Piechowski

2

1 reference

Europe PubMed Central

26 August 2017

Kirk Habegger

3

1 reference

Europe PubMed Central

26 August 2017

Annette Grüters

4

1 reference

Europe PubMed Central

26 August 2017

Heiko Krude

5

1 reference

Europe PubMed Central

26 August 2017

Gunnar Kleinau

7

1 reference

Europe PubMed Central

26 August 2017

Heike Biebermann

8

1 reference

Europe PubMed Central

26 August 2017

publication date

8 February 2012

1 reference

Europe PubMed Central

26 August 2017

Neuroendocrinology

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Europe PubMed Central

26 August 2017

95

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Europe PubMed Central

26 August 2017

4

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Europe PubMed Central

26 August 2017

277-288

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Europe PubMed Central

26 August 2017

Positional cloning of the mouse obese gene and its human homologue

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Obesity wars: molecular progress confronts an expanding epidemic

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A role for pancreatic polypeptide in feeding and body weight regulation

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Ghrelin induces adiposity in rodents

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Post-prandial decrease of circulating human ghrelin levels

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Elevated plasma ghrelin levels in Prader–Willi syndrome

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Circulating ghrelin levels are suppressed by meals and octreotide therapy in children with Prader-Willi syndrome

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Ghrelin in hypothalamic regulation of energy balance.

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GOAT links dietary lipids with the endocrine control of energy balance

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Anatomy and regulation of the central melanocortin system

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Genetic approaches to studying energy balance: perception and integration

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Is the energy homeostasis system inherently biased toward weight gain?

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Significant weight gains in a clinical sample of obese children and adolescents between 1985 and 1995

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G protein-coupled receptor dimers: functional consequences, disease states and drug targets

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Anatomical profiling of G protein-coupled receptor expression

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G protein-coupled receptors in regulation of body weight

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Targeted disruption of the melanocortin-4 receptor results in obesity in mice

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Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

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Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

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The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R).

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Deletions of the N-terminal regions of the human melanocortin receptors

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Molecular determinants of ligand binding to the human melanocortin-4 receptor

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Structure, function and regulation of the melanocortin receptors

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Molecular characterization of human melanocortin-3 receptor ligand-receptor interaction

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Contribution of the conserved amino acids of the melanocortin-4 receptor in [corrected] [Nle4,D-Phe7]-alpha-melanocyte-stimulating [corrected] hormone binding and signaling

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Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.

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Molecular determination of agouti-related protein binding to human melanocortin-4 receptor

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Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin

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High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist

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Common structural basis for constitutive activity of the ghrelin receptor family

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A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors

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Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor

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Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation

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Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor

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Mice lacking ghrelin receptors resist the development of diet-induced obesity

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Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature

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21 January 2018

Four missense mutations in the ghrelin receptor result in distinct pharmacological abnormalities

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Recessive isolated growth hormone deficiency and mutations in the ghrelin receptor

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Identification and functional analysis of novel human growth hormone secretagogue receptor (GHSR) gene mutations in Japanese subjects with short stature.

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21 January 2018

Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10.

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Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

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A role for the melanocortin 4 receptor in sexual function

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Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor ago

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Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists

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Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist.

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Novel pharmacological MC4R agonists can efficiently activate mutated MC4R from obese patient with impaired endogenous agonist response

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Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy

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A pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration

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Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice

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Growth hormone secretagogue (ghrelin-) receptors--a complex drug target for the regulation of body weight

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Ghrelin and its potential in the treatment of eating/wasting disorders and cachexia

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Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity

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Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations

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Synthesis and pharmacological in vitro and in vivo evaluations of novel triazole derivatives as ligands of the ghrelin receptor. 1.

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Structure-activity relationships of the oxindole growth hormone secretagogues

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A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain

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Antagonism of ghrelin receptor reduces food intake and body weight gain in mice

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Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial

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MC4R oligomerizes independently of extracellular cysteine residues

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Identifiers

10.1159/000334903

1 reference

Europe PubMed Central

26 August 2017

1 reference

Europe PubMed Central

26 August 2017

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