Toll-like receptors, the NLRP3 inflammasome, and interleukin-1β in the development and progression of type 1 diabetes (Q37984231)

26 August 2017

Toll-like receptors, the NLRP3 inflammasome, and interleukin-1β in the development and progression of type 1 diabetes (English)

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26 August 2017

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Ellen K Grishman

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26 August 2017

Perrin C White

series ordinal

2

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26 August 2017

Rashmin C Savani

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3

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26 August 2017

language of work or name

English

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publication date

15 February 2012

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26 August 2017

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26 August 2017

71

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26 August 2017

6

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26 August 2017

626-632

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https://scigraph.springernature.com/pub.10.1038/pr.2012.24

26 August 2017

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The cytokine interleukin-1beta reduces the docking and fusion of insulin granules in pancreatic beta-cells, preferentially decreasing the first phase of exocytosis

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

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IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction.

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Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

21 January 2018

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Caspase-1 is not required for type 1 diabetes in the NOD mouse

21 January 2018

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Pioglitazone inhibits Toll-like receptor expression and activity in human monocytes and db/db mice

21 January 2018

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Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

21 January 2018

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IL-1beta receptor blockade protects islets against pro-inflammatory cytokine induced necrosis and apoptosis

21 January 2018

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The pathogenesis of insulin-dependent diabetes mellitus

21 January 2018

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https://api.crossref.org/works/10.1038%2FPR.2012.24

Altered Toll-like receptor signaling pathways in human type 1 diabetes

31 March 2020

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https://api.crossref.org/works/10.1038%2FPR.2012.24

Cachectin/TNF and IL-1 induced by glucose-modified proteins: role in normal tissue remodeling

31 March 2020

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Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis

31 March 2020

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https://api.crossref.org/works/10.1038%2FPR.2012.24

Interleukin-1 reduces the glycolytic utilization of glucose by pancreatic islets and reduces glucokinase mRNA content and protein synthesis by a nitric oxide-dependent mechanism

31 March 2020

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https://api.crossref.org/works/10.1038%2FPR.2012.24

Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes

31 March 2020

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https://api.crossref.org/works/10.1038%2FPR.2012.24

Protection from experimental autoimmune diabetes in the non-obese diabetic mouse with soluble interleukin-1 receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

IL-1 receptor antagonist inhibits recurrence of disease after syngeneic pancreatic islet transplantation to spontaneously diabetic non-obese diabetic (NOD) mice

31 March 2020

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https://api.crossref.org/works/10.1038%2FPR.2012.24

Preliminary studies related to anti-interleukin-1β therapy in children with newly diagnosed type 1 diabetes

31 March 2020

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https://api.crossref.org/works/10.1038%2FPR.2012.24

31 March 2020

Identifiers

DOI

10.1038/PR.2012.24

1 reference

26 August 2017

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