HijAkt: The PI3K/Akt pathway in virus replication and pathogenesis (Q37984841)

26 August 2017

2 references

29 June 2021

22 August 2022

HijAkt: The PI3K/Akt pathway in virus replication and pathogenesis (English)

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post-translational protein modification

26 August 2017

0 references

1 reference

29 June 2021

2

1 reference

26 August 2017

Ewan F Dunn

1

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26 August 2017

1 January 2012

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Progress in Molecular Biology and Translational Science

26 August 2017

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26 August 2017

106

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26 August 2017

223-250

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A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt.

26 August 2017

1 reference

12 December 2020

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

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12 December 2020

Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry

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12 December 2020

Influenza A virus NS1 protein activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K.

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12 December 2020

Anti-BK virus mechanisms of sirolimus and leflunomide alone and in combination: toward a new therapy for BK virus infection

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12 December 2020

Control of protein phosphatase 2A by simian virus 40 small-t antigen

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12 December 2020

Early phosphatidylinositol 3-kinase/Akt pathway activation limits poliovirus-induced JNK-mediated cell death

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12 December 2020

Dominant inhibition of Akt/protein kinase B signaling by the matrix protein of a negative-strand RNA virus

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12 December 2020

Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications.

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12 December 2020

Role of AKT kinase in measles virus replication

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12 December 2020

Epstein-Barr virus latent membrane protein 1 represses DNA repair through the PI3K/Akt/FOXO3a pathway in human epithelial cells

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12 December 2020

Truly emerging--a new disease caused by a novel virus

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12 December 2020

Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication

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12 December 2020

Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling

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12 December 2020

Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses

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12 December 2020

Fever with thrombocytopenia associated with a novel bunyavirus in China

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12 December 2020

Diversity in the mechanisms of neuronal cell death.

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12 December 2020

Mechanism of protein kinase B activation by insulin/insulin-like growth factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase--significance for diabetes and cancer

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12 December 2020

Vesicular stomatitis virus infection alters the eIF4F translation initiation complex and causes dephosphorylation of the eIF4E binding protein 4E-BP1

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12 December 2020

Induction of NF-kappaB by the Akt/PKB kinase

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12 December 2020

The akt kinase: molecular determinants of oncogenicity

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12 December 2020

Activation of the PI3K/Akt Pathway Early during Vaccinia and Cowpox Virus Infections Is Required for both Host Survival and Viral Replication

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12 December 2020

Measles virus induces expression of SIP110, a constitutively membrane clustered lipid phosphatase, which inhibits T cell proliferation

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12 December 2020

Emergence and pandemic potential of swine-origin H1N1 influenza virus

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12 December 2020

Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis

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12 December 2020

Death mechanisms in epithelial cells following rotavirus infection, exposure to inactivated rotavirus or genome transfection.

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12 December 2020

Inhibition of nucleo-cytoplasmic trafficking by RNA viruses: targeting the nuclear pore complex

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12 December 2020

v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation

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12 December 2020

CDK13, a new potential human immunodeficiency virus type 1 inhibitory factor regulating viral mRNA splicing

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12 December 2020

The multifunctional NS1 protein of influenza A viruses

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12 December 2020

Measles virus-induced suppression of immune responses

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12 December 2020

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

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12 December 2020

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

1 reference

12 December 2020

Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation

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12 December 2020

Cytopathogenesis and inhibition of host gene expression by RNA viruses

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12 December 2020

Rhinovirus activates interleukin-8 expression via a Src/p110beta phosphatidylinositol 3-kinase/Akt pathway in human airway epithelial cells.

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12 December 2020

Hepatitis C virus NS5A activates the mammalian target of rapamycin (mTOR) pathway, contributing to cell survival by disrupting the interaction between FK506-binding protein 38 (FKBP38) and mTOR

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12 December 2020

CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection

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12 December 2020

Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins

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12 December 2020

Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

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12 December 2020

Signaling during pathogen infection

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12 December 2020

Role of cell signaling in poxvirus-mediated foreign gene expression in mammalian cells

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12 December 2020

Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus.

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12 December 2020

Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling

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12 December 2020

Akt inhibitor Akt-IV blocks virus replication through an Akt-independent mechanism

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12 December 2020

Rotavirus replication in intestinal cells differentially regulates integrin expression by a phosphatidylinositol 3-kinase-dependent pathway, resulting in increased cell adhesion and virus yield

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12 December 2020

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

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12 December 2020

Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes

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12 December 2020

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

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12 December 2020

Akt plays a critical role in replication of nonsegmented negative-stranded RNA viruses

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12 December 2020

Prospects for immunisation against Marburg and Ebola viruses

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12 December 2020

Akt and mRNA translation by interferons

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12 December 2020

Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production

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12 December 2020

Disruption of M-T5, a novel myxoma virus gene member of poxvirus host range superfamily, results in dramatic attenuation of myxomatosis in infected European rabbits

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12 December 2020

Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathway

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12 December 2020

Human cytomegalovirus major immediate-early proteins and simian virus 40 large T antigen can inhibit apoptosis through activation of the phosphatidylinositide 3'-OH kinase pathway and the cellular kinase Akt.

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12 December 2020

Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytes

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12 December 2020

Role of translocation in the activation and function of protein kinase B

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12 December 2020

Human cytomegalovirus infection induces rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase

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12 December 2020

Phosphatidylinositol 3-kinase regulates macrophage responses to double-stranded RNA and encephalomyocarditis virus

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12 December 2020

Autophagy is an essential component of Drosophila immunity against vesicular stomatitis virus

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12 December 2020

The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells

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12 December 2020

JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activity

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12 December 2020

Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex

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12 December 2020

Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling

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12 December 2020

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

1 reference

12 December 2020

Herpes Simplex Virus is Akt-ing in translational control

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12 December 2020

Rotavirus nonstructural protein 1 suppresses virus-induced cellular apoptosis to facilitate viral growth by activating the cell survival pathways during early stages of infection

1 reference

12 December 2020

Human cytomegalovirus infection maintains mTOR activity and its perinuclear localization during amino acid deprivation

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12 December 2020

Epstein-Barr virus immediate-early protein BRLF1 induces the lytic form of viral replication through a mechanism involving phosphatidylinositol-3 kinase activation

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12 December 2020

Oxidant tone regulates IL-8 production in epithelium infected with respiratory syncytial virus

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12 December 2020

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

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12 December 2020

v-Crk activates the phosphoinositide 3-kinase/AKT pathway by utilizing focal adhesion kinase and H-Ras

1 reference

12 December 2020

Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival.

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12 December 2020

Activation of host translational control pathways by a viral developmental switch

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12 December 2020

Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A.

1 reference

12 December 2020

Mechanisms of severe acute respiratory syndrome pathogenesis and innate immunomodulation

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12 December 2020

Interaction between simian virus 40 large T antigen and insulin receptor substrate 1 is disrupted by the K1 mutation, resulting in the loss of large T antigen-mediated phosphorylation of Akt.

1 reference

12 December 2020

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

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12 December 2020

Simian virus 40 small tumor antigen activates AKT and telomerase and induces anchorage-independent growth of human epithelial cells

1 reference

12 December 2020

Disruption of Akt kinase activation is important for immunosuppression induced by measles virus

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12 December 2020

Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus

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12 December 2020

Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.

1 reference

12 December 2020

Mechanisms and consequences of activation of protein kinase B/Akt

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12 December 2020

The role of the PKR-inhibitory genes, E3L and K3L, in determining vaccinia virus host range

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12 December 2020

Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A

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12 December 2020

Reciprocal regulation of AKT and MAP kinase dictates virus-host cell fusion

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12 December 2020

The myxoma virus m-t5 ankyrin repeat host range protein is a novel adaptor that coordinately links the cellular signaling pathways mediated by Akt and Skp1 in virus-infected cells

1 reference

12 December 2020

Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

1 reference

12 December 2020

Multiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesis

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12 December 2020

Rapamycin reverses splenomegaly and inhibits tumor development in a transgenic model of Epstein-Barr virus-related Burkitt's lymphoma

1 reference

12 December 2020

Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence

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12 December 2020

Norovirus RNA-dependent RNA polymerase is phosphorylated by an important survival kinase, Akt

1 reference

12 December 2020

The human papillomavirus E7 oncoprotein

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12 December 2020

The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation

1 reference

12 December 2020

Protein kinase B/Akt regulates coxsackievirus B3 replication through a mechanism which is not caspase dependent

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12 December 2020

Activation of PI 3-kinase/Akt/NF-kappaB and Stat3 signaling by avian reovirus S1133 in the early stages of infection results in an inflammatory response and delayed apoptosis

1 reference

12 December 2020

Involvement of PP2A in viral and cellular transformation

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12 December 2020

Rapamycin inhibits the interleukin 10 signal transduction pathway and the growth of Epstein Barr virus B-cell lymphomas

1 reference

12 December 2020

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation

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12 December 2020

Herpes simplex virus requires VP11/12 to activate Src family kinase-phosphoinositide 3-kinase-Akt signaling

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12 December 2020

Infection of human cancer cells with myxoma virus requires Akt activation via interaction with a viral ankyrin-repeat host range factor.

1 reference

12 December 2020

Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling.

1 reference

12 December 2020

IRF-3 activation by Sendai virus infection is required for cellular apoptosis and avoidance of persistence

1 reference

12 December 2020

Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein

1 reference

12 December 2020

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1 reference

12 December 2020

Induction of interleukin (IL)-8 gene expression by respiratory syncytial virus involves activation of nuclear factor (NF)-kappa B and NF-IL-6.

1 reference

12 December 2020

Role of the Akt pathway in mRNA translation of interferon-stimulated genes

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12 December 2020

Phosphatidylinositol 3-kinase: the oncoprotein

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12 December 2020

Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins

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12 December 2020

Reverse-phase phosphoproteome analysis of signaling pathways induced by Rift valley fever virus in human small airway epithelial cells

1 reference

12 December 2020

Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway

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12 December 2020

Protein kinase B/Akt is present in activated form throughout the entire replicative cycle of deltaU(S)3 mutant virus but only at early times after infection with wild-type herpes simplex virus 1

1 reference

12 December 2020

Syk associates with clathrin and mediates phosphatidylinositol 3-kinase activation during human rhinovirus internalization.

1 reference

12 December 2020

A newly isolated avian sarcoma virus, ASV-1, carries the crk oncogene

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12 December 2020

PI3K signaling regulates rapamycin-insensitive translation initiation complex formation in vaccinia virus-infected cells

1 reference

12 December 2020

Measles virus-induced immunosuppression: from effectors to mechanisms

1 reference

12 December 2020

The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathway

1 reference

12 December 2020

M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A

1 reference

12 December 2020

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

1 reference

12 December 2020

Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus.

1 reference

12 December 2020

Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus

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12 December 2020

The paramyxovirus simian virus 5 V protein slows progression of the cell cycle

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12 December 2020

Flavivirus Activates Phosphatidylinositol 3-Kinase Signaling To Block Caspase-Dependent Apoptotic Cell Death at the Early Stage of Virus Infection

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12 December 2020

The product of the cellular crk gene consists primarily of SH2 and SH3 regions

1 reference

12 December 2020

Sindbis virus replication, is insensitive to rapamycin and torin1, and suppresses Akt/mTOR pathway late during infection in HEK cells

1 reference

12 December 2020

The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival

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12 December 2020

Coxsackievirus B3 activates nuclear factor kappa B transcription factor via a phosphatidylinositol-3 kinase/protein kinase B-dependent pathway to improve host cell viability

1 reference

12 December 2020

Epstein-Barr virus LMP2A accelerates MYC-induced lymphomagenesis

1 reference

12 December 2020

Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy

1 reference

12 December 2020

TOR signaling in growth and metabolism

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12 December 2020

Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner

1 reference

12 December 2020

The Ras-PI3K signaling pathway is involved in clathrin-independent endocytosis and the internalization of influenza viruses.

1 reference

12 December 2020

10.1016/B978-0-12-396456-4.00002-X

Identifiers

DOI

1 reference

release_5e2blo6qhbddreybf6xng2qe2e

26 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/5e2blo6qhbddreybf6xng2qe2e

24 November 2022

mapped directly with Wikidata item

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1 reference

PubMed ID

22340720