Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation (Q40047113)

16 September 2017

Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation (English)

1 reference

16 September 2017

Benjamin G Hale

1

0 references

author name string

Ian H Batty

series ordinal

2

1 reference

16 September 2017

C Peter Downes

series ordinal

3

1 reference

16 September 2017

Richard E Randall

series ordinal

4

1 reference

16 September 2017

language of work or name

English

0 references

publication date

20 November 2007

1 reference

Journal of Biological Chemistry

16 September 2017

1 reference

16 September 2017

283

1 reference

16 September 2017

1372-1380

1 reference

16 September 2017

3

1 reference

The phosphoinositide 3-kinase pathway

16 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Signalling by PI3K isoforms: insights from gene-targeted mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Regulation of phosphatidylinositol 3'-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Rho family GTPases bind to phosphoinositide kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Cell transformation by the middle T-antigen of polyoma virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Influenza A virus NS1 protein activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signaling pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Intracellular warfare between human influenza viruses and human cells: the roles of the viral NS1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Effect of the phosphatidylinositol 3-kinase/Akt pathway on influenza A virus propagation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

RNA binding by the novel helical domain of the influenza virus NS1 protein requires its dimer structure and a small number of specific basic amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

p110δ, a novel phosphoinositide 3-kinase in leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

SH2 domains recognize specific phosphopeptide sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

X-ray structure of influenza virus NS1 effector domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

The structure of the inter-SH2 domain of class IA phosphoinositide 3-kinase determined by site-directed spin labeling EPR and homology modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

The iSH2 domain of PI 3-kinase is a rigid tether for p110 and not a conformational switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Regulation of a nuclear export signal by an adjacent inhibitory sequence: the effector domain of the influenza virus NS1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

PABP1 and eIF4GI associate with influenza virus NS1 protein in viral mRNA translation initiation complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

The CPSF30 binding site on the NS1A protein of influenza A virus is a potential antiviral target.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Large-scale sequence analysis of avian influenza isolates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

Interferon Antagonists of Influenza Viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708862200

21 January 2018

Identifiers

DOI

10.1074/JBC.M708862200

1 reference

16 September 2017

1 reference