Liver X receptors, atherosclerosis and inflammation (Q37993787)

26 August 2017

Liver X receptors, atherosclerosis and inflammation (English)

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26 August 2017

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Daryn R Michael

1

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26 August 2017

Tim G Ashlin

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2

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26 August 2017

Melanie L Buckley

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3

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26 August 2017

Dipak P Ramji

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4

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26 August 2017

1 June 2012

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Current Atherosclerosis Reports

26 August 2017

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26 August 2017

14

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26 August 2017

284-293

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26 August 2017

3

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https://scigraph.springernature.com/pub.10.1007/s11883-012-0239-y

26 August 2017

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cites work

Lipid ligand-activated transcription factors regulating lipid storage and release in human macrophages

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Integration of metabolism and inflammation by lipid-activated nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

The liver X receptor: control of cellular lipid homeostasis and beyond Implications for drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Role of LXRs in control of lipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Liver X receptor-alpha gene expression is positively regulated by thyroid hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

IFN-gamma down-regulates ABCA1 expression by inhibiting LXRalpha in a JAK/STAT signaling pathway-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

A liver X receptor (LXR)-beta alternative splicing variant (LXRBSV) acts as an RNA co-activator of LXR-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Phosphorylation of the liver X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Protein kinase C alpha modulates liver X receptor alpha transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Phosphorylation of liver X receptor alpha selectively regulates target gene expression in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

A novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

SIRT1 deacetylates and positively regulates the nuclear receptor LXR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Nuclear receptor liver X receptor is O-GlcNAc-modified in response to glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Laminar shear stress regulates liver X receptor in vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Liver X receptor stimulates cholesterol efflux and inhibits expression of proinflammatory mediators in human airway smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

LXR-induced reverse cholesterol transport in human airway smooth muscle is mediated exclusively by ABCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Peroxisome proliferator-activated receptor-α activation promotes macrophage reverse cholesterol transport through a liver X receptor-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Erythropoietin suppresses the formation of macrophage foam cells: role of liver X receptor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Atorvastatin inhibits ABCA1 expression and cholesterol efflux in THP-1 macrophages by an LXR-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Liver X receptor activation induces the uptake of cholesteryl esters from high density lipoproteins in primary human macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Accumulation of foam cells in liver X receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Identification of macrophage liver X receptors as inhibitors of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

LXR as a novel antithrombotic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Regulation of macrophage functions by PPAR-alpha, PPAR-gamma, and LXRs in mice and men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Stimulation of cholesterol efflux by LXR agonists in cholesterol-loaded human macrophages is ABCA1-dependent but ABCG1-independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

A novel potent synthetic steroidal liver X receptor agonist lowers plasma cholesterol and triglycerides and reduces atherosclerosis in LDLR(-/-) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver X receptor agonist in low-density lipoprotein receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Liver X receptor agonist methyl-3β-hydroxy-5α,6α-epoxycholanate attenuates atherosclerosis in apolipoprotein E knockout mice without increasing plasma triglyceride

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Effect of macrophage overexpression of murine liver X receptor-alpha (LXR-alpha) on atherosclerosis in LDL-receptor deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Macrophage LXRα gene therapy ameliorates atherosclerosis as well as hypertriglyceridemia in LDLR(-/-) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Improved lipid profile through liver-specific knockdown of liver X receptor alpha in KKAy diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Liver X receptor activation decreases the severity of experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Liver X receptor and retinoid X receptor agonists inhibit inflammatory responses of microglia and astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Activation of liver X receptors promotes neuroprotection and reduces brain inflammation in experimental stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

The arginase II gene is an anti-inflammatory target of liver X receptor in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Liver x receptor agonists inhibit cytokine-induced osteopontin expression in macrophages through interference with activator protein-1 signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Coronin 2A mediates actin-dependent de-repression of inflammatory response genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Interferon gamma: a master regulator of atherosclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Differential SUMOylation of LXRalpha and LXRbeta mediates transrepression of STAT1 inflammatory signaling in IFN-gamma-stimulated brain astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Liver X Receptor Activation Potentiates the Lipopolysaccharide Response in Human Macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Liver X receptor agonism promotes articular inflammation in murine collagen-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-012-0239-Y

Liver X receptor activator downregulates angiotensin II type 1 receptor expression through dephosphorylation of Sp1

21 January 2018

1 reference

12 December 2020

Synergistic effect of liver X receptor activation and simvastatin on plaque regression and stabilization: an magnetic resonance imaging study in a model of advanced atherosclerosis

1 reference

12 December 2020

Synergistic activation of RLD-1 by agents triggering PKA and PKC dependent signalling

1 reference

12 December 2020

Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists

1 reference

12 December 2020

Activation of Liver X Receptor Sensitizes Human Dendritic Cells to Inflammatory Stimuli

1 reference

12 December 2020

10.1007/S11883-012-0239-Y

Identifiers

DOI

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26 August 2017

1 reference