Through the fog: recent clinical trials to preserve β-cell function in type 1 diabetes (Q38012381)

27 August 2017

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Through the fog: recent clinical trials to preserve β-cell function in type 1 diabetes (English)

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27 August 2017

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human digestive system

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insulin-secreting cells

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27 January 2021

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Carla J Greenbaum

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Desmond A Schatz

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Michael J Haller

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Srinath Sanda

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27 August 2017

language of work or name

English

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publication date

1 June 2012

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inferred from page(s)

published in

Diabetes

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Creative Commons Attribution-NonCommercial-NoDerivatives

27 August 2017

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on focus list of Wikimedia project

ScienceSource

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cites work

Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function

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Control of TH17 cells occurs in the small intestine.

6 September 2017

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Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial

6 September 2017

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Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial

6 September 2017

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Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial

6 September 2017

1 reference

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Predicting harms and benefits in translational trials: ethics, evidence, and uncertainty

6 September 2017

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Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes

6 September 2017

1 reference

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Autologous hematopoietic stem cell transplantation in autoimmune diseases

6 September 2017

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Advances in the prediction and natural history of type 1 diabetes

6 September 2017

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Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes

6 September 2017

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Failure to preserve beta-cell function with mycophenolate mofetil and daclizumab combined therapy in patients with new- onset type 1 diabetes

6 September 2017

1 reference

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Etanercept treatment in children with new-onset type 1 diabetes: pilot randomized, placebo-controlled, double-blind study

6 September 2017

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C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus

6 September 2017

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Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes

6 September 2017

1 reference

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GAD treatment and insulin secretion in recent-onset type 1 diabetes

6 September 2017

1 reference

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Glucose and C-peptide changes in the perionset period of type 1 diabetes in the Diabetes Prevention Trial-Type 1.

6 September 2017

1 reference

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Type 1 diabetes as a relapsing-remitting disease?

6 September 2017

1 reference

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CD3-specific antibodies: a portal to the treatment of autoimmunity

6 September 2017

1 reference

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Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus

6 September 2017

1 reference

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Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes

6 September 2017

1 reference

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A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes

6 September 2017

1 reference

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Can the pharmaceutical industry reduce attrition rates?

6 September 2017

1 reference

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Type 1 diabetes: recent developments

6 September 2017

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Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala).

6 September 2017

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Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

6 September 2017

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Type 1 diabetes intervention trials: what have we learned? A critical review of selected intervention trials

6 September 2017

1 reference

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Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes

6 September 2017

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Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice

6 September 2017

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The TrialNet Natural History Study of the Development of Type 1 Diabetes: objectives, design, and initial results

6 September 2017

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Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

14 September 2017

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Newborn screening for HLA markers associated with IDDM: diabetes autoimmunity study in the young (DAISY).

14 September 2017

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Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass.

28 September 2017

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The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design

31 August 2018

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Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1.

31 August 2018

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Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY).

31 August 2018

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Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial

31 August 2018

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Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

31 August 2018

1 reference

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On the appearance of islet associated autoimmunity in offspring of diabetic mothers: a prospective study from birth

3 December 2018

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12 December 2020

Rapid HLA-DQB1 genotyping for four alleles in the assessment of risk for IDDM in the Finnish population. The Childhood Diabetes in Finland (DiMe) Study Group

1 reference

12 December 2020

Dynamic changes of GAD65 autoantibody epitope specificities in individuals at risk of developing type 1 diabetes

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12 December 2020

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial

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12 December 2020

Identifiers

DOI

10.2337/DB11-1452

1 reference

27 August 2017

1 reference

27 August 2017

1 reference