Targeting the liver kinase B1/AMP-activated protein kinase pathway as a therapeutic strategy for hematological malignancies (Q38017727)

27 August 2017

title

Targeting the liver kinase B1/AMP-activated protein kinase pathway as a therapeutic strategy for hematological malignancies (English)

1 reference

27 August 2017

Francesca Chiarini

2

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Camilla Evangelisti

object named as

Camilla Evangelisti

3

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James A. McCubrey

object named as

James A McCubrey

9

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author name string

Alberto M Martelli

1

1 reference

27 August 2017

Andrea Ognibene

4

1 reference

27 August 2017

Daniela Bressanin

5

1 reference

27 August 2017

Anna Maria Billi

6

1 reference

27 August 2017

Lucia Manzoli

7

1 reference

27 August 2017

Alessandra Cappellini

8

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27 August 2017

language of work or name

English

0 references

publication date

12 June 2012

1 reference

Expert Opinion on Therapeutic Targets

27 August 2017

published in

1 reference

27 August 2017

volume

16

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27 August 2017

issue

7

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27 August 2017

page(s)

729-742

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AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

27 August 2017

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AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha

21 January 2018

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Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators

21 January 2018

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Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.

21 January 2018

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Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis

21 January 2018

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AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5

21 January 2018

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Inhibition of contraction-stimulated AMP-activated protein kinase inhibits contraction-stimulated increases in PAS-TBC1D1 and glucose transport without altering PAS-AS160 in rat skeletal muscle

21 January 2018

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Metformin induces Rab4 through AMPK and modulates GLUT4 translocation in skeletal muscle cells

21 January 2018

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21 January 2018

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Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

21 January 2018

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Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis

21 January 2018

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

21 January 2018

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The role of the Atg1/ULK1 complex in autophagy regulation

21 January 2018

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mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

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21 January 2018

The two TORCs and Akt.

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TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

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Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1

21 January 2018

1 reference

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Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia

21 January 2018

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Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

21 January 2018

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 January 2018

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Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

21 January 2018

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The LKB1 tumor suppressor negatively regulates mTOR signaling

21 January 2018

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Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer.

21 January 2018

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Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction

21 January 2018

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The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

21 January 2018

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Pharmacological management of type 2 diabetes mellitus: an update

21 January 2018

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LKB1 and mammalian target of rapamycin as predictive factors for the anticancer efficacy of metformin

21 January 2018

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Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells

21 January 2018

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Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

21 January 2018

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Regulation of TORC1 by Rag GTPases in nutrient response

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 January 2018

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21 January 2018

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21 January 2018

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The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

21 January 2018

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21 January 2018

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Different effects of thiazolidinediones on cardiovascular risk in patients with type 2 diabetes mellitus: pioglitazone versus rosiglitazone

21 January 2018

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Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase

21 January 2018

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21 January 2018

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Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP

21 January 2018

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Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

21 January 2018

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Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action

21 January 2018

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Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols

21 January 2018

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Metformin and reduced risk of cancer in diabetic patients

21 January 2018

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21 January 2018

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Minireview: IGF, Insulin, and Cancer

21 January 2018

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21 January 2018

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Diabetes mellitus and breast cancer: a retrospective population-based cohort study.

21 January 2018

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Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

21 January 2018

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Histological evaluation of AMPK signalling in primary breast cancer

21 January 2018

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21 January 2018

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Drugging the PI3 kinome: from chemical tools to drugs in the clinic.

21 January 2018

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Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

21 January 2018

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Metformin and cancer therapy.

21 January 2018

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Metformin: multi-faceted protection against cancer

21 January 2018

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Metformin and neoplasia: implications and indications

21 January 2018

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Signal transduction inhibitors in chronic lymphocytic leukemia

21 January 2018

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AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells.

21 January 2018

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The Bcl-2 apoptotic switch in cancer development and therapy

21 January 2018

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Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death

21 January 2018

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Optimizing the selection of kinase inhibitors for chronic myeloid leukemia patients

21 January 2018

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Antileukemic effects of AMPK activators on BCR-ABL-expressing cells

21 January 2018

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AMPK- and p62/SQSTM1-dependent autophagy mediate resveratrol-induced cell death in chronic myelogenous leukemia.

21 January 2018

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Biology, risk stratification, and therapy of pediatric acute leukemias: an update

21 January 2018

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Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy

21 January 2018

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Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

21 January 2018

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Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways.

21 January 2018

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AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia

21 January 2018

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ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy.

21 January 2018

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AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.694869

AMP-activated protein kinase promotes human prostate cancer cell growth and survival

21 January 2018

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Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.694869

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.694869

Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.694869

Acadesine induces apoptosis in B cells from mantle cell lymphoma and splenic marginal zone lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.694869

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.694869

Functional interleukin-7 receptors (IL-7Rs) are expressed by marrow stromal cells: binding of IL-7 increases levels of IL-6 mRNA and secreted protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.694869

Autophagy augmented by troglitazone is independent of EGFR transactivation and correlated with AMP-activated protein kinase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.694869

Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.694869

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.694869

Dual inhibition of PI3K and mTORC1/2 signaling by NVP-BEZ235 as a new therapeutic strategy for acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.694869

Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.694869

RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.694869

Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.694869

Cell cycle regulation in hematopoietic stem cells

21 January 2018

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Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

21 January 2018

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21 January 2018

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The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis.

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Targeting the leukemic stem cell: the Holy Grail of leukemia therapy

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Targeted elimination of leukemia stem cells; a new therapeutic approach in hemato-oncology

21 January 2018

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The 5' adenosine monophosphate-activated protein kinase: regulating the ebb and flow of cellular energetics

21 January 2018

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21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference