Degradation of tau protein by autophagy and proteasomal pathways (Q38027933)

27 August 2017

title

Degradation of tau protein by autophagy and proteasomal pathways (English)

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27 August 2017

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2

Eckhard Mandelkow

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27 August 2017

Yipeng Wang

1

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27 August 2017

language of work or name

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1 August 2012

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Biochemical Society Transactions

27 August 2017

published in

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27 August 2017

volume

40

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27 August 2017

issue

4

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27 August 2017

page(s)

644-652

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Tau-based treatment strategies in neurodegenerative diseases

27 August 2017

cites work

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Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity

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Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment

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A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration

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Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro

21 January 2018

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Aminopeptidases do not directly degrade tau protein

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120071

Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice

21 January 2018

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Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy

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Integration of Clearance Mechanisms: The Proteasome and Autophagy

21 January 2018

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Ubiquitin-proteasome pathway and cellular responses to oxidative stress

21 January 2018

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Ubiquitin is a component of paired helical filaments in Alzheimer's disease.

21 January 2018

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Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains

21 January 2018

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Ubiquitin and microtubule-associated protein tau immunoreactivity each define distinct structures with differing distributions and solubility properties in Alzheimer brain

21 January 2018

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Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

21 January 2018

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Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation

21 January 2018

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The tau of MARK: a polarized view of the cytoskeleton

21 January 2018

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The acetylation of tau inhibits its function and promotes pathological tau aggregation

21 January 2018

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U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120071

Tau protein degradation is catalyzed by the ATP/ubiquitin-independent 20S proteasome under normal cell conditions.

21 January 2018

1 reference

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The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

21 January 2018

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Ubiquitin enters the new millennium

21 January 2018

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Recognition of the polyubiquitin proteolytic signal

21 January 2018

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Dual modification of Alzheimer's disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach

21 January 2018

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Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120071

In vivo evidence of CHIP up-regulation attenuating tau aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Proteasomal degradation of tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Microtubule-associated protein tau is a substrate of ATP/Mg(2+)-dependent proteasome protease system

21 January 2018

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Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Tau is not normally degraded by the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Autophagic degradation of tau in primary neurons and its enhancement by trehalose.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120071

Rapamycin induces autophagic flux in neurons

21 January 2018

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Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

21 January 2018

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Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120071

A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

A caspase cleaved form of tau is preferentially degraded through the autophagy pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120071

Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120071

Acetylation of tau inhibits its degradation and contributes to tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

The roles of intracellular protein-degradation pathways in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Molecular chaperones in protein folding and proteostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Chaperones increase association of tau protein with microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Human BAG-1/RAP46 protein is generated as four isoforms by alternative translation initiation and overexpressed in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

BAG-1M is up-regulated in hippocampus of Alzheimer's disease patients and associates with tau and APP proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Distinct isoforms of the cofactor BAG-1 differentially affect Hsc70 chaperone function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Chemical manipulation of hsp70 ATPase activity regulates tau stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Pathophysiology of chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Alz-50/Gallyas-positive lysosome-like intraneuronal granules in Alzheimer's disease and control brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Lysosomal protease inhibitors induce meganeurites and tangle-like structures in entorhinohippocampal regions vulnerable to Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Accumulation of tau in autophagic vacuoles in chloroquine myopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Chloroquine myopathy suggests that tau is degraded in lysosomes: implication for the formation of paired helical filaments in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Hallmark cellular pathology of Alzheimer's disease induced by mutant human tau expression in cultured Aplysia neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Tau normal function influences Niemann-Pick type C disease pathogenesis in mice and modulates autophagy in NPC1-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Aβ Oligomers Cause Localized Ca2+Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Abeta inhibits the proteasome and enhances amyloid and tau accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Aging and dietary restriction alter proteasome biogenesis and composition in the brain and liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Aging and regulated protein degradation: who has the UPPer hand?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Aging perturbs 26S proteasome assembly in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120071

21 January 2018

Identifiers

DOI

10.1042/BST20120071

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27 August 2017

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