A double-edged sword with therapeutic potential: an updated role of autophagy in ischemic cerebral injury. (Q38045416)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22998350%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

A double-edged sword with therapeutic potential: an updated role of autophagy in ischemic cerebral injury (English)

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13 February 2020

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2

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13 February 2020

Chao-Yu Miao

series ordinal

3

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13 February 2020

author name string

Kai Wei

series ordinal

1

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publication date

24 September 2012

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CNS Neuroscience & Therapeutics

13 February 2020

published in

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13 February 2020

volume

18

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13 February 2020

issue

11

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13 February 2020

page(s)

879-886

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13 February 2020

1 reference

Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic.

21 January 2018

1 reference

Review of tissue plasminogen activator, ischemic stroke, and potential legal issues

21 January 2018

1 reference

The science of stroke: mechanisms in search of treatments

21 January 2018

1 reference

Apoptotic mechanisms after cerebral ischemia

21 January 2018

1 reference

Autophagy in the Pathogenesis of Disease

21 January 2018

1 reference

Nonredundant role of Atg7 in mitochondrial clearance during erythroid development.

21 January 2018

1 reference

Autophagy in mammalian development and differentiation

21 January 2018

1 reference

Autophagy gene-dependent clearance of apoptotic cells during embryonic development

21 January 2018

1 reference

Autophagy in immunity and inflammation

21 January 2018

1 reference

Autophagy controls plant basal immunity in a pathogenic lifestyle-dependent manner

21 January 2018

1 reference

Autophagy, Immunity, and Microbial Adaptations

21 January 2018

1 reference

Autophagy genes in immunity

21 January 2018

1 reference

21 January 2018

Autophagy and metabolism

1 reference

The emerging role of autophagy in the pathophysiology of diabetes mellitus

21 January 2018

1 reference

Potential role of autophagy in modulation of lipid metabolism

21 January 2018

1 reference

21 January 2018

1 reference

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease.

21 January 2018

1 reference

The protective role of autophagy against aging and acute ischemic injury in kidney proximal tubular cells.

21 January 2018

1 reference

p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects.

21 January 2018

1 reference

Control of autophagy as a therapy for neurodegenerative disease

21 January 2018

1 reference

Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation

21 January 2018

1 reference

The unfolded protein response and proteostasis in Alzheimer disease: preferential activation of autophagy by endoplasmic reticulum stress.

21 January 2018

1 reference

Lysosomal membrane permeabilization in Parkinson disease

21 January 2018

1 reference

Targeting histone deacetylases for the treatment of Huntington's disease.

21 January 2018

1 reference

The double-edged effect of autophagy in pancreatic beta cells and diabetes

21 January 2018

1 reference

Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes

21 January 2018

1 reference

AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathy

21 January 2018

1 reference

Autophagy and adipogenesis: implications in obesity and type II diabetes

21 January 2018

1 reference

Autophagy: roles in obesity-induced ER stress and adiponectin downregulation in adipocytes

21 January 2018

1 reference

The role of autophagy in cancer development and response to therapy.

21 January 2018

1 reference

ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy

21 January 2018

1 reference

Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer

21 January 2018

1 reference

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.

21 January 2018

1 reference

Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis.

21 January 2018

1 reference

Mitochondria and the autophagy-inflammation-cell death axis in organismal aging

21 January 2018

1 reference

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

21 January 2018

1 reference

Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy.

21 January 2018

1 reference

Acute induction of autophagy as a novel strategy for cardioprotection: getting to the heart of the matter

21 January 2018

1 reference

Autophagy in ALDH2-elicited cardioprotection against ischemic heart disease: slayer or savior?

21 January 2018

1 reference

Autophagy is induced by ischemic preconditioning in human livers formerly treated by chemotherapy to limit necrosis

21 January 2018

1 reference

Autophagic neuron death in neonatal brain ischemia/hypoxia

21 January 2018

1 reference

Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

All-you-can-eat: autophagy in neurodegeneration and neuroprotection.

21 January 2018

1 reference

Autophagy for the avoidance of neurodegeneration

21 January 2018

1 reference

The role of tau in Alzheimer's disease and related disorders

21 January 2018

1 reference

Toward a unifying hypothesis in the development of Alzheimer's disease.

21 January 2018

1 reference

A defect in cytosolic carboxypeptidase 1 (Nna1) causes autophagy in Purkinje cell degeneration mouse brain

21 January 2018

1 reference

Eaten alive: autophagy and neuronal cell death after hypoxia-ischemia.

21 January 2018

1 reference

Autophagy in acute brain injury: feast, famine, or folly?

21 January 2018

1 reference

Death and survival of neuronal and astrocytic cells in ischemic brain injury: a role of autophagy

21 January 2018

1 reference

Regulation mechanisms and signaling pathways of autophagy

21 January 2018

1 reference

Eaten alive: a history of macroautophagy

21 January 2018

1 reference

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

21 January 2018

1 reference

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.

21 January 2018

1 reference

AMPK and autophagy get connected.

21 January 2018

1 reference

AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation.

21 January 2018

1 reference

Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1.

21 January 2018

1 reference

Beclin 1 or not Beclin 1...

21 January 2018

1 reference

LC3 conjugation system in mammalian autophagy

21 January 2018

1 reference

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

21 January 2018

1 reference

Autophagy suppresses tumorigenesis through elimination of p62

21 January 2018

1 reference

Physiological significance of selective degradation of p62 by autophagy

21 January 2018

1 reference

A reporter cell system to monitor autophagy based on p62/SQSTM1.

21 January 2018

1 reference

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

21 January 2018

1 reference

ULK1 inhibits the kinase activity of mTORC1 and cell proliferation

21 January 2018

1 reference

ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding

21 January 2018

1 reference

The association of AMPK with ULK1 regulates autophagy

21 January 2018

1 reference

Chaperone-Mediated Autophagy

21 January 2018

1 reference

Microautophagy in mammalian cells: revisiting a 40-year-old conundrum

21 January 2018

1 reference

Chasing the elusive mammalian microautophagy

21 January 2018

1 reference

Cell death pathways and autophagy in the central nervous system and its involvement in neurodegeneration, immunity and central nervous system infection: to die or not to die--that is the question

21 January 2018

1 reference

Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation

21 January 2018

1 reference

Seeing is believing: the impact of electron microscopy on autophagy research

21 January 2018

1 reference

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

21 January 2018

1 reference

Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy

21 January 2018

1 reference

Autophagy and protein aggregation after brain ischemia

21 January 2018

1 reference

Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia

21 January 2018

1 reference

Postischemic treatment of neonatal cerebral ischemia should target autophagy.

21 January 2018

1 reference

RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats

21 January 2018

1 reference

Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia

21 January 2018

1 reference

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

21 January 2018

1 reference

Enhancement of autophagic flux after neonatal cerebral hypoxia-ischemia and its region-specific relationship to apoptotic mechanisms

21 January 2018

1 reference

Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury

21 January 2018

1 reference

Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury

21 January 2018

1 reference

Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia

21 January 2018

1 reference

Autophagy activation is involved in neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats.

21 January 2018

1 reference

Hyperbaric oxygen preconditioning reduces ischemia-reperfusion injury by stimulating autophagy in neurocyte

21 January 2018

1 reference

In vivo imaging of autophagy in a mouse stroke model

21 January 2018

1 reference

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

21 January 2018

1 reference

Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

1 reference

Autophagic cell death and its execution by lysosomal cathepsins

21 January 2018

1 reference

Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways

21 January 2018

1 reference

Constitutive reactive oxygen species generation from autophagosome/lysosome in neuronal oxidative toxicity

21 January 2018

1 reference

Antiapoptotic and antiautophagic effects of glial cell line-derived neurotrophic factor and hepatocyte growth factor after transient middle cerebral artery occlusion in rats

21 January 2018

1 reference

NAD(+) administration decreases ischemic brain damage partially by blocking autophagy in a mouse model of brain ischemia.

21 January 2018

1 reference

Retracted: Propofol Prevents Autophagic Cell Death following Oxygen and Glucose Deprivation in PC12 Cells and Cerebral Ischemia-Reperfusion Injury in Rats

21 January 2018

1 reference

Beta-asarone attenuates ischemia-reperfusion-induced autophagy in rat brains via modulating JNK, p-JNK, Bcl-2 and Beclin 1.

21 January 2018

1 reference

Lithium reduces apoptosis and autophagy after neonatal hypoxia-ischemia

21 January 2018

1 reference

Transmembrane protein 166 regulates autophagic and apoptotic activities following focal cerebral ischemic injury in rats.

21 January 2018

1 reference

Intranasal ginsenoside Rb1 targets the brain and ameliorates cerebral ischemia/reperfusion injury in rats.

21 January 2018

1 reference

Tetrahydrocurcumin ameliorates homocysteinylated cytochrome-c mediated autophagy in hyperhomocysteinemia mice after cerebral ischemia.

21 January 2018

1 reference

Selenium preserves mitochondrial function, stimulates mitochondrial biogenesis, and reduces infarct volume after focal cerebral ischemia

21 January 2018

1 reference

Exacerbation of ischemia-induced amyloid-beta generation by diabetes is associated with autophagy activation in mice brain

21 January 2018

1 reference

3-n-Butylphthalide (NBP) attenuated neuronal autophagy and amyloid-β expression in diabetic mice subjected to brain ischemia

21 January 2018

1 reference

Amlodipine and atorvastatin exert protective and additive effects via antiapoptotic and antiautophagic mechanisms after transient middle cerebral artery occlusion in Zucker metabolic syndrome rats

21 January 2018

1 reference

Manganese superoxide dismutase deficiency exacerbates ischemic brain damage under hyperglycemic conditions by altering autophagy

21 January 2018

1 reference

GSK-3β inhibitors suppressed neuroinflammation in rat cortex by activating autophagy in ischemic brain injury.

21 January 2018

1 reference

Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: functional analysis of p62 and autophagy in hypoxic neuronal cells

21 January 2018

1 reference

Melatonin protects N2a against ischemia/reperfusion injury through autophagy enhancement

21 January 2018

1 reference

Cerebral preconditioning and ischaemic tolerance

21 January 2018

1 reference

Autophagy induced by ischemic preconditioning is essential for cardioprotection.

21 January 2018

1 reference

Hypoxic preconditioning reinforces HIF-alpha-dependent HSP70 signaling to reduce ischemic renal failure-induced renal tubular apoptosis and autophagy

21 January 2018

1 reference

Autophagy is involved in the ischemic preconditioning

21 January 2018

1 reference

Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning

21 January 2018

1 reference

Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning.

21 January 2018

1 reference

Autophagy in hypoxia-ischemia induced brain injury.

21 January 2018

1 reference

Hyperbaric oxygen therapy and cerebral ischemia: neuroprotective mechanisms

21 January 2018

1 reference

Autophagy: from phenomenology to molecular understanding in less than a decade

21 January 2018

1 reference

PI3K signaling of autophagy is required for starvation tolerance and virulenceof Cryptococcus neoformans

21 January 2018

1 reference

Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy.

21 January 2018

1 reference

eEF-2 kinase, another meddler in the "yin and yang" of Akt-mediated cell fate?

21 January 2018

1 reference

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

21 January 2018

1 reference

Autophagy and Akt promote survival in glioma

21 January 2018

1 reference

The Skp2 promoter integrates signaling through the NF-kappaB, p53, and Akt/GSK3beta pathways to regulate autophagy and apoptosis.

21 January 2018

1 reference

Akt and autophagy cooperate to promote survival of drug-resistant glioma

21 January 2018

1 reference

Warts is required for PI3K-regulated growth arrest, autophagy, and autophagic cell death in Drosophila

21 January 2018

1 reference

The life of a cell: apoptosis regulation by the PI3K/PKB pathway

21 January 2018

1 reference

Akt, FoxO and regulation of apoptosis

21 January 2018

1 reference

TOR signaling in growth and metabolism

21 January 2018

1 reference

Molecular mechanisms of mTOR-mediated translational control

21 January 2018

1 reference

Broadening the therapeutic scope for rapamycin treatment

21 January 2018

1 reference

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

21 January 2018

1 reference

Methods in mammalian autophagy research

21 January 2018

1 reference

Beclin 1-independent autophagy contributes to apoptosis in cortical neurons

21 January 2018

1 reference

The rat Apg3p/Aut1p homolog is upregulated by ischemic preconditioning in the retina

21 January 2018

1 reference

12 December 2020

Autophagy: a new regulator of development

1 reference

12 December 2020

Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death

1 reference

12 December 2020

The Arabidopsis thaliana ACBP3 regulates leaf senescence by modulating phospholipid metabolism and ATG8 stability

1 reference

12 December 2020

Therapy mediated by mitophagy abrogates tumor progression

1 reference

12 December 2020

Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: a widely used inhibitor of autophagy

1 reference

12 December 2020

In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice

1 reference

12 December 2020

2-methoxyestradiol attenuates autophagy activation after global ischemia

1 reference

12 December 2020

Metabolic regulation by HMGB1-mediated autophagy and mitophagy

1 reference

12 December 2020

Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice

1 reference

12 December 2020

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis.

1 reference

12 December 2020

Identifiers

DOI

10.1111/CNS.12005

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13 February 2020

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13 February 2020

PubMed publication ID

22998350

1 reference

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