The function of sub-synaptic vesicles during T-cell activation (Q38070786)

28 August 2017

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title

The function of sub-synaptic vesicles during T-cell activation (English)

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28 August 2017

Marco A Purbhoo

1

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28 August 2017

publication date

1 January 2013

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28 August 2017

published in

Immunological Reviews

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28 August 2017

volume

251

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28 August 2017

issue

1

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28 August 2017

page(s)

36-48

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The immunological synapse: a molecular machine controlling T cell activation

28 August 2017

cites work

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Three-dimensional segregation of supramolecular activation clusters in T cells

21 January 2018

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Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

21 January 2018

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Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling

21 January 2018

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TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.

21 January 2018

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Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor

21 January 2018

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Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells

21 January 2018

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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

21 January 2018

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Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function

21 January 2018

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The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

21 January 2018

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T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

21 January 2018

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Direct observation of ligand recognition by T cells.

21 January 2018

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T cell killing does not require the formation of a stable mature immunological synapse.

21 January 2018

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T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

21 January 2018

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T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

21 January 2018

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Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation

21 January 2018

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Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.

21 January 2018

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A microtubule-binding protein associated with membranes of the Golgi apparatus

21 January 2018

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Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization

21 January 2018

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Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism

21 January 2018

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Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells

21 January 2018

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Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.

21 January 2018

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Recruitment of dynein to the Jurkat immunological synapse

21 January 2018

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Centrosome polarization delivers secretory granules to the immunological synapse.

21 January 2018

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The cytoskeletal adaptor protein IQGAP1 regulates TCR-mediated signaling and filamentous actin dynamics.

21 January 2018

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Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse

21 January 2018

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Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization

21 January 2018

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HDAC6 deacetylase activity links the tubulin cytoskeleton with immune synapse organization

21 January 2018

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Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse; involvement of SNARE complexes.

21 January 2018

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The immunological synapse of CTL contains a secretory domain and membrane bridges.

21 January 2018

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Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4

21 January 2018

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Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

21 January 2018

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Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice

21 January 2018

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Rab27a is required for regulated secretion in cytotoxic T lymphocytes

21 January 2018

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Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing.

21 January 2018

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Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex

21 January 2018

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Myosin IIA is required for cytolytic granule exocytosis in human NK cells

21 January 2018

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Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse

21 January 2018

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Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopy

21 January 2018

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Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse

21 January 2018

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The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse

21 January 2018

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Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain

21 January 2018

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Receptor-directed focusing of lymphokine release by helper T cells

21 January 2018

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T cells use two directionally distinct pathways for cytokine secretion.

21 January 2018

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Human CD8+ T cells store RANTES in a unique secretory compartment and release it rapidly after TcR stimulation

21 January 2018

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Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation

21 January 2018

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Dynamic recruitment of the adaptor protein LAT: LAT exists in two distinct intracellular pools and controls its own recruitment

21 January 2018

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Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation.

21 January 2018

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A role for endobrevin/VAMP8 in CTL lytic granule exocytosis

21 January 2018

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Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity

21 January 2018

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SNAREs are concentrated in cholesterol-dependent clusters that define docking and fusion sites for exocytosis

21 January 2018

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c-Cbl-mediated regulation of LAT-nucleated signaling complexes

21 January 2018

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Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses

21 January 2018

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Internalization of human T lymphocyte receptors

21 January 2018

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T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis

21 January 2018

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Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation.

21 January 2018

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Rab35 regulates neurite outgrowth and cell shape.

21 January 2018

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Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation

21 January 2018

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Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapse

21 January 2018

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High-speed high-resolution imaging of intercellular immune synapses using optical tweezers

21 January 2018

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Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade

21 January 2018

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Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav

21 January 2018

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Dynamic regulation of Tec kinase localization in membrane-proximal vesicles of a T cell clone revealed by total internal reflection fluorescence and confocal microscopy

21 January 2018

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Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4

21 January 2018

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Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells

21 January 2018

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Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.

21 January 2018

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Altered actin centripetal retrograde flow in physically restricted immunological synapses

21 January 2018

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T cell antigen receptor signaling and immunological synapse stability require myosin IIA

21 January 2018

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B cell receptor-mediated antigen gathering requires ubiquitin ligase Cbl and adaptors Grb2 and Dok-3 to recruit dynein to the signaling microcluster.

21 January 2018

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Powering membrane traffic in endocytosis and recycling

21 January 2018

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Ig-like transcript 2 (ILT2)/leukocyte Ig-like receptor 1 (LIR1) inhibits TCR signaling and actin cytoskeleton reorganization.

21 January 2018

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Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

21 January 2018

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Endosomal entry regulates Notch receptor activation in Drosophila melanogaster

21 January 2018

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The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.

21 January 2018

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Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec

21 January 2018

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Imaging T-cell receptor activation reveals accumulation of tyrosine-phosphorylated CD3ζ in the endosomal compartment.

21 January 2018

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T-Cell Antigen Receptor-Induced Signaling Complexes: Internalization Via a Cholesterol-Dependent Endocytic Pathway

21 January 2018

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Dynein-Driven Transport of T Cell Receptor Microclusters Regulates Immune Synapse Formation and T Cell Activation

21 January 2018

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Evidences for ubiquitination and intracellular trafficking of LAT, the linker of activated T cells

21 January 2018

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Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/IMR.12012

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28 August 2017

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