Hutchinson-Gilford progeria syndrome through the lens of transcription (Q38089892)

28 August 2017

Hutchinson-Gilford progeria syndrome through the lens of transcription (English)

1 reference

28 August 2017

1 reference

Miron Prokocimer

1

1 reference

PubMed ID

23496208

28 August 2017

Rachel Barkan

series ordinal

2

1 reference

PubMed ID

23496208

28 August 2017

Yosef Gruenbaum

series ordinal

3

1 reference

28 August 2017

19 April 2013

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28 August 2017

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28 August 2017

12

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28 August 2017

4

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28 August 2017

533-543

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Effect of lamin A/C knockdown on osteoblast differentiation and function

28 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Notch signaling: simplicity in design, versatility in function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Role of A-type lamins in signaling, transcription, and chromatin organization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

The nuclear lamina and heterochromatin: a complex relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Multiple and surprising new functions for emerin, a nuclear membrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Impact papers on aging in 2009.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Telomeres and human disease: ageing, cancer and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Role of transforming growth factor beta in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Lamins: 'structure goes cycling'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Cellular mechanisms of tumour suppression by the retinoblastoma gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Progeria syndromes and ageing: what is the connection?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Cellular senescence: when bad things happen to good cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Notch signaling in osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Altered pre-lamin A processing is a common mechanism leading to lipodystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Lamin A precursor induces barrier-to-autointegration factor nuclear localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Inhibition of beta-catenin signaling causes defects in postnatal cartilage development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

The nuclear envelope protein MAN1 regulates TGFbeta signaling and vasculogenesis in the embryonic yolk sac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Cellular senescence in cancer and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Coupling of the nucleus and cytoplasm: role of the LINC complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Lamin a truncation in Hutchinson-Gilford progeria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Chromatin modifications: the driving force of senescence and aging?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Subcellular localization of SREBP1 depends on its interaction with the C-terminal region of wild-type and disease related A-type lamins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Diverse roles and interactions of the SWI/SNF chromatin remodeling complex revealed using global approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Hypertonic-induced lamin A/C synthesis and distribution to nucleoplasmic speckles is mediated by TonEBP/NFAT5 transcriptional activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Relationships at the nuclear envelope: lamins and nuclear pore complexes in animals and plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Lamin B1 loss is a senescence-associated biomarker.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Role of Rb family in the epigenetic definition of chromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

A-type lamin complexes and regenerative potential: a step towards understanding laminopathic diseases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Notch signaling in vascular development and physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

The nuclear lamina and its functions in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Progeria of stem cells: stem cell exhaustion in Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Tethering by lamin A stabilizes and targets the ING1 tumour suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

The inner nuclear envelope as a transcription factor resting place

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Hutchinson-Gilford progeria syndrome: review of the phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Multiple roles for emerin: implications for Emery-Dreifuss muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

The defective nuclear lamina in Hutchinson-gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Wnt signalling and its impact on development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Identification of differential protein interactors of lamin A and progerin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Transforming growth factor-beta and notch signaling mediate stem cell differentiation into smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Cancer biology and NuRD: a multifaceted chromatin remodelling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

miR-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Genomic instability in laminopathy-based premature aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

The nuclear envelope can control gene expression and cell cycle progression via miRNA regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Expression of disease-causing lamin A mutants impairs the formation of DNA repair foci

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

SREBP1 interaction with prelamin A forms: a pathogenic mechanism for lipodystrophic laminopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

A-type lamins and signaling: the PI 3-kinase/Akt pathway moves forward

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

An EDMD mutation in C. elegans lamin blocks muscle-specific gene relocation and compromises muscle integrity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Dynamic interactions of nuclear lamina proteins with chromatin and transcriptional machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

The spatial dynamics of tissue-specific promoters during C. elegans development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Phenotype and course of Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Altered chromosomal positioning, compaction, and gene expression with a lamin A/C gene mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Disruption of nuclear lamin organization blocks the elongation phase of DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

DNA-damage accumulation and replicative arrest in Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Cardiovascular pathology in Hutchinson-Gilford progeria: correlation with the vascular pathology of aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Role of the nuclear lamina in genome organization and gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Discordant gene expression signatures and related phenotypic differences in lamin A- and A/C-related Hutchinson-Gilford progeria syndrome (HGPS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Gene expression, chromosome position and lamin A/C mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

The emerging role of cardiovascular risk factor-induced mitochondrial dysfunction in atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Inhibition of lamin A/C attenuates osteoblast differentiation and enhances RANKL-dependent osteoclastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

The nuclear lamina promotes telomere aggregation and centromere peripheral localization during senescence of human mesenchymal stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Regulating the levels of key factors in cell cycle and DNA repair: new pathways revealed by lamins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Adipocyte differentiation from the inside out

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Linking functional decline of telomeres, mitochondria and stem cells during ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Axis of ageing: telomeres, p53 and mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Telomere dysfunction induces metabolic and mitochondrial compromise.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Lamin A-dependent nuclear defects in human aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

The role of nuclear lamin B1 in cell proliferation and senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

LAP2 binds to BAF.DNA complexes: requirement for the LEM domain and modulation by variable regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

The highly conserved nuclear lamin Ig-fold binds to PCNA: its role in DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

PPARgamma in adipocyte differentiation and metabolism--novel insights from genome-wide studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

The nucleoskeleton as a genome-associated dynamic 'network of networks'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Lamin A tail modification by SUMO1 is disrupted by familial partial lipodystrophy-causing mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

After a decade of study-ING, a PHD for a versatile family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

The nuclear-envelope protein and transcriptional repressor LAP2beta interacts with HDAC3 at the nuclear periphery, and induces histone H4 deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Communication between the cytoskeleton and the nuclear envelope to position the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Chromatin: constructing the big picture

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Peroxisome proliferator-activated receptor gamma and cardiovascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Hutchinson-Gilford progeria syndrome, cardiovascular disease and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Nuclear functions of actin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

21 January 2018

Lamin-binding Proteins

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

Nuclear mechanics in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

An association of Hutchinson–Gilford progeria and malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12070

21 January 2018

Identifiers

DOI

10.1111/ACEL.12070

1 reference

28 August 2017

1 reference

PubMed ID

23496208