Protein truncation as a common denominator of human neurodegenerative foldopathies (Q38091670)

28 August 2017

title

Protein truncation as a common denominator of human neurodegenerative foldopathies (English)

1 reference

28 August 2017

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Santosh Jadhav

1

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28 August 2017

Norbert Zilka

series ordinal

2

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28 August 2017

Michal Novak

series ordinal

3

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28 August 2017

publication date

21 March 2013

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28 August 2017

published in

Molecular Neurobiology

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28 August 2017

volume

48

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28 August 2017

issue

3

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28 August 2017

page(s)

516-532

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Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease

28 August 2017

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Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

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Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease

21 January 2018

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Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

21 January 2018

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Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy

21 January 2018

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Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme

21 January 2018

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Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1).

21 January 2018

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Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases

21 January 2018

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Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment

21 January 2018

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Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases

21 January 2018

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Expression of the receptor for advanced glycation end products in Huntington's disease caudate nucleus

21 January 2018

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Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer's disease

21 January 2018

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Ataxin-10 interacts with O-linked beta-N-acetylglucosamine transferase in the brain

21 January 2018

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Nitration of tau protein is linked to neurodegeneration in tauopathies

21 January 2018

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Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats

21 January 2018

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SUMO modification of Huntingtin and Huntington's disease pathology

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

SUMOylation of the polyglutamine repeat protein, ataxin-1, is dependent on a functional nuclear localization signal

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Proteasome inhibition induces α-synuclein SUMOylation and aggregate formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Transition of tau protein from disordered to misordered in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Expression of a truncated tau protein induces oxidative stress in a rodent model of tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

A NH2 tau fragment targets neuronal mitochondria at AD synapses: possible implications for neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Identification of amino-terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Proteolytic processing in the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Truncated tau expression levels determine life span of a rat model of tauopathy without causing neuronal loss or correlating with terminal neurofibrillary tangle load

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

First transgenic rat model developing progressive cortical neurofibrillary tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

The role of caspase cleavage of tau in Alzheimer disease neuropathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Caspase activation precedes and leads to tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Role of N-terminal tau domain integrity on the survival of cerebellar granule neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Characterization and localization of the Huntington disease gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Biochemistry and molecular biology of amyloid beta-protein and the mechanism of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

An overview of APP processing enzymes and products

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Impact of the acidic C-terminal region comprising amino acids 109-140 on alpha-synuclein aggregation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

On the sequential determinants of calpain cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Calpain-resistant fragment(s) of alpha-synuclein regulates the synuclein-cleaving activity of 20S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Phosphorylation and cleavage of tau in non-AD tauopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Mechanisms of neurodegeneration in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Oxidative stress induces nuclear translocation of C-terminus of alpha-synuclein in dopaminergic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

A "two-hit" hypothesis for inclusion formation by carboxyl-terminal fragments of TDP-43 protein linked to RNA depletion and impaired microtubule-dependent transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

The lysosome and neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Proteolysis of tau by calpain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

The calpain family and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Inhibition of β-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Calpain inhibitor MDL28170 modulates Abeta formation by inhibiting the formation of intermediate Abeta46 and protecting Abeta from degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Caspases in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Sequential activation of individual caspases, and of alterations in Bcl‐2 proapoptotic signals in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Caspase activation during apoptotic cell death induced by expanded polyglutamine in N2a cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Huntingtin inhibits caspase-3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

A possible role for cathepsins D, E, and B in the processing of beta-amyloid precursor protein in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

Processing of the Pre‐β‐amyloid Protein by Cathepsin d is Enhanced by a Familial Alzheimer's Disease Mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8440-8

In vitro processing of amyloid precursor protein by cathepsin D.

21 January 2018

1 reference

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Characterization of beta-amyloid peptide from human cerebrospinal fluid

21 January 2018

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Processing of beta-amyloid precursor protein by cathepsin D.

21 January 2018

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Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein

21 January 2018

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Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease

21 January 2018

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Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species

21 January 2018

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Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.

21 January 2018

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Nonenzymatic Deamidation of Asparaginyl and Glutaminyl Residues in Protein

21 January 2018

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Molecular aging of tau: disulfide-independent aggregation and non-enzymatic degradation in vitro and in vivo

21 January 2018

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Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau.

21 January 2018

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Deamidation accelerates amyloid formation and alters amylin fiber structure

21 January 2018

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Deamidation of alpha-synuclein

21 January 2018

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Structure-dependent nonenzymatic deamidation of glutaminyl and asparaginyl pentapeptides

21 January 2018

1 reference

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Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease

21 January 2018

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Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

21 January 2018

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Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

21 January 2018

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Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

21 January 2018

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12 December 2020

Degradation of tau by lysosomal enzyme cathepsin D: implication for Alzheimer neurofibrillary degeneration.

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Analysis of the alpha-synuclein G209A mutation in familial Parkinson's disease

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Aggregate formation and the impairment of long-term synaptic facilitation by ectopic expression of mutant huntingtin in Aplysia neurons.

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Alzheimer's-disease-associated conformation of intrinsically disordered tau protein studied by intrinsically disordered protein liquid-phase competitive enzyme-linked immunosorbent assay

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Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

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12 December 2020

Conformational changes and cleavage of tau in Pick bodies parallel the early processing of tau found in Alzheimer pathology

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12 December 2020

C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease.

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12 December 2020

Calpain‐Induced Proteolysis of Normal Human Tau and Tau Associated with Paired Helical Filaments

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12 December 2020

Characterisation of the first monoclonal antibody against the pronase resistant core of the Alzheimer PHF.

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Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

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12 December 2020

Proteolytic processing of beta-amyloid precursor by calpain I.

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Role of glutamine deamidation in neurodegenerative diseases associated with triplet repeat expansions: a hypothesis

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Calpain activation in Huntington's disease.

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12 December 2020

Role of advanced glycation on aggregation and DNA binding properties of α-synuclein.

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12 December 2020

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

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12 December 2020

[Hereditary Parkinson disease: report of 3 families with dominant autosomal inheritance]

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12 December 2020

Hyperphosphorylated Truncated Protein Tau Induces Caspase-3 Independent Apoptosis-Like Pathway in the Alzheimer's Disease Cellular Model

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12 December 2020

Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively

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12 December 2020

The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease

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12 December 2020

Molecular analysis of neurofibrillary degeneration in Alzheimer's disease. An immunohistochemical study

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12 December 2020

Oxidative stress-induced phosphorylation, degradation and aggregation of alpha-synuclein are linked to upregulated CK2 and cathepsin D

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12 December 2020

The sensitivity of c-Jun and c-Fos proteins to calpains depends on conformational determinants of the monomers and not on formation of dimers

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12 December 2020

Tissue-specific proteolysis of Huntingtin (htt) in human brain: evidence of enhanced levels of N- and C-terminal htt fragments in Huntington's disease striatum.

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12 December 2020

Wild-type huntingtin protects from apoptosis upstream of caspase-3.

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12 December 2020

Full-length and truncated Alzheimer amyloid precursors in chromaffin granules: solubilization of membrane amyloid precursor is mediated by an enzymatic mechanism.

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12 December 2020

Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease

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12 December 2020

Calmodulin-binding proteins as calpain substrates.

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12 December 2020

Increased neuronal Rab5 immunoreactive endosomes do not colocalize with TDP-43 in motor neuron disease

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12 December 2020

In Vivo Imaging Reveals Dissociation between Caspase Activation and Acute Neuronal Death in Tangle-Bearing Neurons

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12 December 2020

Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates

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12 December 2020

Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament

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12 December 2020

Genetic linkage between Huntington's disease and the DNA polymorphism G8 in South Wales families

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12 December 2020

Truncated tau protein as a new marker for Alzheimer's disease.

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12 December 2020

Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation

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12 December 2020

10.1007/S12035-013-8440-8

Identifiers

DOI

1 reference

Dimensions Publication ID

28 August 2017

1034867114

0 references

1 reference