A daunting task: manipulating leukocyte function with RNAi (Q38095502)

28 August 2017

title

A daunting task: manipulating leukocyte function with RNAi (English)

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28 August 2017

1

Dan Peer

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28 August 2017

publication date

1 May 2013

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28 August 2017

published in

Immunological Reviews

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28 August 2017

volume

253

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28 August 2017

issue

1

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28 August 2017

page(s)

185-197

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

28 August 2017

cites work

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Approaches for chemically synthesized siRNA and vector-mediated RNAi

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Knocking down disease with siRNAs

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RNA interference in biology and disease

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Special delivery: targeted therapy with small RNAs.

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Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target

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An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

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Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation

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Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

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RNA inhibition highlights cyclin D1 as a potential therapeutic target for mantle cell lymphoma

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RNAi-based nanomedicines for targeted personalized therapy

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RNAi-mediated gene silencing in non-human primates.

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siRNA relieves chronic neuropathic pain

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Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1.

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Allele-specific silencing of dominant disease genes

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Silencing primary dystonia: lentiviral-mediated RNA interference therapy for DYT1 dystonia.

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RNAi therapeutics: a potential new class of pharmaceutical drugs

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A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

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siRNA and innate immunity

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Chemical modification of siRNAs for in vivo use.

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The silent treatment: siRNAs as small molecule drugs

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Strategies for silencing human disease using RNA interference

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Progress towards in vivo use of siRNAs

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The silent revolution: RNA interference as basic biology, research tool, and therapeutic

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Grand challenges in modulating the immune response with RNAi nanomedicines.

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An immobilized nanoparticle-based platform for efficient gene knockdown of targeted cells in the circulation

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Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein

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Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy

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Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

21 January 2018

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In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

21 January 2018

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Downregulation of monocyte chemoattractant protein-1 involving short interfering RNA attenuates hapten-induced contact hypersensitivity

21 January 2018

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T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice

21 January 2018

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Targeted Delivery of Small Interfering RNA to Human Dendritic Cells To Suppress Dengue Virus Infection and Associated Proinflammatory Cytokine Production

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Targeted delivery of siRNA to macrophages for anti-inflammatory treatment

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Transvascular delivery of small interfering RNA to the central nervous system.

21 January 2018

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Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1.

21 January 2018

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Adhesion receptors of the immune system

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Integrins: bidirectional, allosteric signaling machines

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Natalizumab Induction and Maintenance Therapy for Crohn's Disease

21 January 2018

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Therapeutic antagonists and conformational regulation of integrin function

21 January 2018

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Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation

21 January 2018

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Induction of therapeutic gene silencing in leukocyte-implicated diseases by targeted and stabilized nanoparticles: a mini-review.

21 January 2018

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Dynamic partitioning into lipid rafts controls the endo-exocytic cycle of the alphaL/beta2 integrin, LFA-1, during leukocyte chemotaxis

21 January 2018

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In vitro internalization, intracellular transport, and clearance of an anti-CD11a antibody (Raptiva) by human T-cells

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Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm

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Lymphocyte homing and homeostasis

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Conformational regulation of integrin structure and function

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AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes.

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Integrin-targeted nanoparticles for siRNA delivery.

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RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice

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The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation.

21 January 2018

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Immunotoxicity derived from manipulating leukocytes with lipid-based nanoparticles

21 January 2018

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Altering the immune response with lipid-based nanoparticles.

21 January 2018

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Hyaluronan is a key component in cryoprotection and formulation of targeted unilamellar liposomes

21 January 2018

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Loading mitomycin C inside long circulating hyaluronan targeted nano-liposomes increases its antitumor activity in three mice tumor models

21 January 2018

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Tumor-targeted hyaluronan nanoliposomes increase the antitumor activity of liposomal Doxorubicin in syngeneic and human xenograft mouse tumor models

21 January 2018

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Polysaccharides as building blocks for nanotherapeutics

21 January 2018

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Hyaluronan-coated nanoparticles: the influence of the molecular weight on CD44-hyaluronan interactions and on the immune response.

21 January 2018

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Cyclin D1 serves as a cell cycle regulatory switch in actively proliferating cells

21 January 2018

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Targeting cyclins and cyclin-dependent kinases in cancer: lessons from mice, hopes for therapeutic applications in human

21 January 2018

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Cyclin D1: polymorphism, aberrant splicing and cancer risk

21 January 2018

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Minireview: Cyclin D1: normal and abnormal functions

21 January 2018

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Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression

21 January 2018

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Cell cycle progression without cyclin D-CDK4 and cyclin D-CDK6 complexes

21 January 2018

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Targeting Stat3 in cancer therapy

21 January 2018

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Cyclin D1 in breast cancer pathogenesis

21 January 2018

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Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics

21 January 2018

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Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

21 January 2018

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21 January 2018

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The RB and p53 pathways in cancer

21 January 2018

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Pathogenesis of mantle-cell lymphoma: all oncogenic roads lead to dysregulation of cell cycle and DNA damage response pathways

21 January 2018

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Antibody-mediated delivery of siRNAs for anti-HIV therapy

21 January 2018

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Molecular biology. The art of assembly

21 January 2018

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Hyaluronan-grafted particle clusters loaded with Mitomycin C as selective nanovectors for primary head and neck cancers

21 January 2018

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Hyaluronan grafted lipid-based nanoparticles as RNAi carriers for cancer cells

21 January 2018

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Role of Toll-like receptors in antisense and siRNA [corrected].

21 January 2018

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Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3.

21 January 2018

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Activation of the interferon system by short-interfering RNAs

21 January 2018

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Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

21 January 2018

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Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses

21 January 2018

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Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization

21 January 2018

1 reference

siRNA and isRNA: two edges of one sword

21 January 2018

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Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification

21 January 2018

1 reference

Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo

21 January 2018

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Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

21 January 2018

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Nanomedicine based approaches for the delivery of siRNA in cancer

21 January 2018

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Cationic liposomes as vaccine adjuvants

21 January 2018

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Liposome based systems for systemic siRNA delivery: stability in blood sets the requirements for optimal carrier design

21 January 2018

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Synthesis and characterization of degradable multivalent cationic lipids with disulfide-bond spacers for gene delivery

21 January 2018

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A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

21 January 2018

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Multifunctional nanoparticles delivering small interfering RNA and doxorubicin overcome drug resistance in cancer.

21 January 2018

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Assessing cellular toxicities in fibroblasts upon exposure to lipid-based nanoparticles: a high content analysis approach

21 January 2018

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Cationic liposomal lipids: from gene carriers to cell signaling

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Modulation of cardiac macrophages by phosphatidylserine-presenting liposomes improves infarct repair

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Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo

21 January 2018

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Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

21 January 2018

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Accelerated clearance of a second injection of PEGylated liposomes in mice

21 January 2018

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Alendronate liposomes for antitumor therapy: activation of γδ T cells and inhibition of tumor growth

21 January 2018

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Liposome-cell interactions in vitro: effect of liposome surface charge on the binding and endocytosis of conventional and sterically stabilized liposomes

21 January 2018

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Interaction of dendritic cells with antigen-containing liposomes: effect of bilayer composition

21 January 2018

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Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver

21 January 2018

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Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy.

21 January 2018

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Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery

21 January 2018

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Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth

21 January 2018

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On future's doorstep: RNA interference and the pharmacopeia of tomorrow

21 January 2018

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Sustained small interfering RNA delivery by mesoporous silicon particles

21 January 2018

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Targeting melanoma growth and metastasis with systemic delivery of liposome-incorporated protease-activated receptor-1 small interfering RNA.

21 January 2018

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Nanoparticle hydrophobicity dictates immune response

21 January 2018

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Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction

21 January 2018

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Lipidic carriers of siRNA: differences in the formulation, cellular uptake, and delivery with plasmid DNA.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/IMR.12044

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28 August 2017

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