Epigenomics and the regulation of aging (Q38097110)

28 August 2017

Epigenomics and the regulation of aging (English)

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28 August 2017

Jerome D Boyd-Kirkup

1

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28 August 2017

Christopher D Green

2

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28 August 2017

Gang Wu

3

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28 August 2017

Dan Wang

4

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28 August 2017

Jing-Dong J Han

5

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28 August 2017

1 April 2013

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28 August 2017

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28 August 2017

5

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28 August 2017

2

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28 August 2017

205-227

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Understanding the odd science of aging

28 August 2017

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Sex and death: what is the connection?

21 January 2018

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ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis

21 January 2018

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piRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans

21 January 2018

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21 January 2018

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Genetic modulation of senescent phenotypes in Homo sapiens

21 January 2018

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DNA Damage, Aging, and Cancer

21 January 2018

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Mitochondria, oxidants, and aging

21 January 2018

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Premature ageing in mice expressing defective mitochondrial DNA polymerase

21 January 2018

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How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

21 January 2018

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Taking a "good" look at free radicals in the aging process

21 January 2018

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Ageing, genes, environment and epigenetics: what twin studies tell us now, and in the future

21 January 2018

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Genome-environment interactions that modulate aging: powerful targets for drug discovery

21 January 2018

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Calorie restriction--the SIR2 connection

21 January 2018

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Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

21 January 2018

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Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

21 January 2018

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Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster

21 January 2018

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Nutritional influences on aging of Fischer 344 rats: I. Physical, metabolic, and longevity characteristics.

21 January 2018

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Caloric restriction delays disease onset and mortality in rhesus monkeys

21 January 2018

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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

21 January 2018

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The plasticity of aging: insights from long-lived mutants

21 January 2018

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Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

21 January 2018

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Sirtuins as regulators of mammalian aging

21 January 2018

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Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

21 January 2018

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Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes

21 January 2018

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A high-resolution, nucleosome position map of C. elegans reveals a lack of universal sequence-dictated positioning

21 January 2018

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Next-generation sequencing in aging research: emerging applications, problems, pitfalls and possible solutions

21 January 2018

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Caenorhabditis elegans DNA does not contain 5-methylcytosine at any time during development or aging

21 January 2018

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A genome-wide study of DNA methylation patterns and gene expression levels in multiple human and chimpanzee tissues.

21 January 2018

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MethylomeDB: a database of DNA methylation profiles of the brain.

21 January 2018

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Human DNA methylomes at base resolution show widespread epigenomic differences

21 January 2018

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Evidence for non-CpG methylation in mammals.

21 January 2018

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Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

21 January 2018

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Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG [correction of non-CpA] sites

21 January 2018

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In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases

21 January 2018

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Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA.

21 January 2018

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Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements

21 January 2018

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

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Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

21 January 2018

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Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.

21 January 2018

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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

21 January 2018

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Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

21 January 2018

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Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

21 January 2018

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Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood

21 January 2018

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Epigenetic choreographers of neurogenesis in the adult mammalian brain

21 January 2018

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Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA

21 January 2018

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Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region

21 January 2018

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Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine

21 January 2018

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Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: implications for X-chromosome inactivation

21 January 2018

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Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning

21 January 2018

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Conserved role of intragenic DNA methylation in regulating alternative promoters

21 January 2018

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Dynamic changes in the human methylome during differentiation

21 January 2018

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High resolution methylome map of rat indicates role of intragenic DNA methylation in identification of coding region

21 January 2018

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Contrasting chromatin organization of CpG islands and exons in the human genome

21 January 2018

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Deciphering a methylome: what can we read into patterns of DNA methylation?

21 January 2018

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ICF syndrome mutations cause a broad spectrum of biochemical defects in DNMT3B-mediated de novo DNA methylation

21 January 2018

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DNA-binding factors shape the mouse methylome at distal regulatory regions

21 January 2018

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Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity.

21 January 2018

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Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

21 January 2018

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Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L.

21 January 2018

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The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

21 January 2018

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Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells

21 January 2018

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Identification of genetic elements that autonomously determine DNA methylation states.

21 January 2018

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Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island

21 January 2018

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Sequences sufficient for programming imprinted germline DNA methylation defined.

21 January 2018

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The influence of cis-regulatory elements on DNA methylation fidelity

21 January 2018

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Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification

21 January 2018

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A high-resolution map of active promoters in the human genome

21 January 2018

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Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping

21 January 2018

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The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote

21 January 2018

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Combinatorial patterns of histone acetylations and methylations in the human genome

21 January 2018

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Modeling gene expression using chromatin features in various cellular contexts

21 January 2018

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An integrated encyclopedia of DNA elements in the human genome

21 January 2018

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A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

21 January 2018

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Signals and combinatorial functions of histone modifications

21 January 2018

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Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

21 January 2018

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Aging, cancer and nutrition: the DNA methylation connection

21 January 2018

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Insufficient DNA methylation affects healthy aging and promotes age-related health problems

21 January 2018

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Distinct DNA methylomes of newborns and centenarians

21 January 2018

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Intra-individual change over time in DNA methylation with familial clustering

21 January 2018

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Decline in genomic DNA methylation through aging in a cohort of elderly subjects

21 January 2018

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DNA methylation as a biomarker for cardiovascular disease risk

21 January 2018

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Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study

21 January 2018

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DNA methylation profiling of human chromosomes 6, 20 and 22

21 January 2018

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Aging and epigenetics: longitudinal changes in gene-specific DNA methylation

21 January 2018

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Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology

21 January 2018

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Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains

21 January 2018

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Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context

21 January 2018

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Distinct DNA methylation changes highly correlated with chronological age in the human brain

21 January 2018

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The emergence of DNA methylation as a key modulator of aberrant cell death in prostate cancer.

21 January 2018

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Cellular senescence and chromatin structure

21 January 2018

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Apoptosis and aging: increased resistance to apoptosis enhances the aging process

21 January 2018

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Epigenetic predictor of age

21 January 2018

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Aging and chronic sun exposure cause distinct epigenetic changes in human skin

21 January 2018

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Multiple tumor suppressor genes are increasingly methylated with age in non-neoplastic gastric epithelia.

21 January 2018

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Postnatal development- and age-related changes in DNA-methylation patterns in the human genome

21 January 2018

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5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging

21 January 2018

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Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts

21 January 2018

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Age-dependent decreases in DNA methyltransferase levels and low transmethylation micronutrient levels synergize to promote overexpression of genes implicated in autoimmunity and acute coronary syndromes

21 January 2018

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Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities

21 January 2018

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Neuronal activity modifies the DNA methylation landscape in the adult brain

21 January 2018

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Widespread and tissue specific age-related DNA methylation changes in mice.

21 January 2018

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Population-specificity of human DNA methylation

21 January 2018

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Epigenetic drift in aging identical twins

21 January 2018

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Epigenetic differences arise during the lifetime of monozygotic twins

21 January 2018

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Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs

21 January 2018

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21 January 2018

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Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression

21 January 2018

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Effects of caloric restriction in animals on cellular function, oncogene expression, and DNA methylation in vitro

21 January 2018

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A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss.

21 January 2018

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The ageing epigenome: damaged beyond repair?

21 January 2018

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Stress-associated H3K4 methylation accumulates during postnatal development and aging of rhesus macaque brain.

21 January 2018

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The DNA-damage response in human biology and disease

21 January 2018

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ATR and ATRIP: partners in checkpoint signaling

21 January 2018

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Requirement of the MRN complex for ATM activation by DNA damage

21 January 2018

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

21 January 2018

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ATM phosphorylates histone H2AX in response to DNA double-strand breaks

21 January 2018

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ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

21 January 2018

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Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

21 January 2018

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Megabase chromatin domains involved in DNA double-strand breaks in vivo

21 January 2018

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gammaH2AX foci form preferentially in euchromatin after ionising-radiation.

21 January 2018

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Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

21 January 2018

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Histone ubiquitination: triggering gene activity

21 January 2018

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ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks

21 January 2018

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RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response.

21 January 2018

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Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

21 January 2018

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Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

21 January 2018

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Docking onto chromatin via the Saccharomyces cerevisiae Rad9 Tudor domain.

21 January 2018

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Di-methyl H4 lysine 20 targets the checkpoint protein Crb2 to sites of DNA damage

21 January 2018

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Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage

21 January 2018

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Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

21 January 2018

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MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

21 January 2018

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Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

21 January 2018

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Essential functions of the histone demethylase lid

21 January 2018

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MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair

21 January 2018

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Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

21 January 2018

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SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging

21 January 2018

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Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast

21 January 2018

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SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

21 January 2018

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Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

21 January 2018

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SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

21 January 2018

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Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.

21 January 2018

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Dynamic chromatin localization of Sirt6 shapes stress- and aging-related transcriptional networks.

21 January 2018

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Histone H4-K16 acetylation controls chromatin structure and protein interactions

21 January 2018

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Histone H4 lysine 16 acetylation regulates cellular lifespan

21 January 2018

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Lamin A-dependent nuclear defects in human aging

21 January 2018

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Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

21 January 2018

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

21 January 2018

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Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA

21 January 2018

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H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence

21 January 2018

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Cellular senescence in aging primates.

21 January 2018

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DNA methyltransferase gene dDnmt2 and longevity of Drosophila

21 January 2018

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Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2

21 January 2018

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Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population

21 January 2018

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Analysis of alternative splicing associated with aging and neurodegeneration in the human brain.

21 January 2018

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

21 January 2018

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Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

21 January 2018

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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

21 January 2018

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Altered histone acetylation is associated with age-dependent memory impairment in mice.

21 January 2018

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Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

21 January 2018

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Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway.

21 January 2018

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The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner

21 January 2018

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Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin/IGF-1 signaling in C. elegans

21 January 2018

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Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans

21 January 2018

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MicroRNAs both promote and antagonize longevity in C. elegans.

21 January 2018

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MicroRNA predictors of longevity in Caenorhabditis elegans

21 January 2018

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A developmental timing microRNA and its target regulate life span in C. elegans

21 January 2018

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Genome-wide miRNA signatures of human longevity.

21 January 2018

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microRNA expression patterns reveal differential expression of target genes with age.

21 January 2018

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Novel microRNAs differentially expressed during aging in the mouse brain

21 January 2018

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Genome-wide analysis of miRNA expression reveals a potential role for miR-144 in brain aging and spinocerebellar ataxia pathogenesis.

21 January 2018

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Circulatory miR34a as an RNAbased, noninvasive biomarker for brain aging

21 January 2018

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The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO

21 January 2018

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MicroRNA group disorganization in aging

21 January 2018

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Transgenerational inheritance of an acquired small RNA-based antiviral response in C. elegans

21 January 2018

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Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans.

21 January 2018

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An epigenetic role for maternally inherited piRNAs in transposon silencing

21 January 2018

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piRNA-mediated transgenerational inheritance of an acquired trait

21 January 2018

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A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice

21 January 2018

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Long non-coding RNAs in nervous system function and disease

21 January 2018

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Longevity is not influenced by prenatal programming of body size

21 January 2018

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RNA-mediated response to heat shock in mammalian cells

21 January 2018

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Polycomb-repressed genes have permissive enhancers that initiate reprogramming

21 January 2018

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Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA.

21 January 2018

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DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

21 January 2018

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UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells

21 January 2018

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SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities

21 January 2018

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H2A.Z maintenance during mitosis reveals nucleosome shifting on mitotically silenced genes

21 January 2018

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CTCF: master weaver of the genome

21 January 2018

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CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

21 January 2018

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Widespread plasticity in CTCF occupancy linked to DNA methylation

21 January 2018

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Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

21 January 2018

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A family of human zinc finger proteins that bind methylated DNA and repress transcription

21 January 2018

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In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions

21 January 2018

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Dnmt3a is essential for hematopoietic stem cell differentiation

21 January 2018

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Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line

21 January 2018

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Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

21 January 2018

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Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation

21 January 2018

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DNA methylation does not stably lock gene expression but instead serves as a molecular mark for gene silencing memory

21 January 2018

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RNAi-mediated pathways in the nucleus

21 January 2018

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Small RNA guides for de novo DNA methylation in mammalian germ cells

21 January 2018

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Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes

21 January 2018

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Oligomerization of DNMT3A controls the mechanism of de novo DNA methylation

21 January 2018

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Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells

21 January 2018

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Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters.

21 January 2018

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Linking the epigenome to the genome: correlation of different features to DNA methylation of CpG islands

21 January 2018

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Comparative epigenomic annotation of regulatory DNA.

21 January 2018

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Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine.

21 January 2018

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The role of DNA methylation in aging, rejuvenation, and age-related disease

21 January 2018

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Specific method for the determination of genomic DNA methylation by liquid chromatography-electrospray ionization tandem mass spectrometry

21 January 2018

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Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

21 January 2018

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Genome-wide DNA methylation profiling using Infinium® assay

21 January 2018

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A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands

21 January 2018

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The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing

21 January 2018

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Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling

21 January 2018

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Chromatin and sequence features that define the fine and gross structure of genomic methylation patterns.

21 January 2018

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A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis

21 January 2018

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One-pot shotgun quantitative mass spectrometry characterization of histones

21 January 2018

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Global analysis of mRNA decay and abundance in Escherichia coli at single-gene resolution using two-color fluorescent DNA microarrays

21 January 2018

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Genome-wide mapping of in vivo protein-DNA interactions

21 January 2018

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Immunoprecipitation of native chromatin: NChIP.

21 January 2018

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Next-generation DNA sequencing of paired-end tags (PET) for transcriptome and genome analyses

21 January 2018

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An oestrogen-receptor-α-bound human chromatin interactome

21 January 2018

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Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization

21 January 2018

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Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/EPI.13.5

1 reference

28 August 2017

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