Blood-brain barrier structure and function and the challenges for CNS drug delivery (Q38100970)

28 August 2017

title

Blood-brain barrier structure and function and the challenges for CNS drug delivery (English)

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28 August 2017

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N Joan Abbott

1

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28 August 2017

publication date

23 April 2013

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Journal of Inherited Metabolic Disease

28 August 2017

published in

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28 August 2017

volume

36

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28 August 2017

issue

3

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28 August 2017

page(s)

437-449

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Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology

28 August 2017

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21 January 2018

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Receptor-mediated transcytosis of lactoferrin through the blood-brain barrier.

21 January 2018

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An improved low-permeability in vitro-model of the blood-brain barrier: transport studies on retinoids, sucrose, haloperidol, caffeine and mannitol

21 January 2018

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21 January 2018

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21 January 2018

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Chemically modified beta-glucuronidase crosses blood-brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII.

21 January 2018

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New strategies for enzyme replacement therapy for lysosomal storage diseases

21 January 2018

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Evaluation of miglustat treatment in patients with type III mucopolysaccharidosis: a randomized, double-blind, placebo-controlled study

21 January 2018

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Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease

21 January 2018

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On the rate and extent of drug delivery to the brain.

21 January 2018

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Intercellular interactomics of human brain endothelial cells and th17 lymphocytes: a novel strategy for identifying therapeutic targets of CNS inflammation

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

21 January 2018

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Heterogeneous Blood–Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer

21 January 2018

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21 January 2018

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21 January 2018

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Genistein improves neuropathology and corrects behaviour in a mouse model of neurodegenerative metabolic disease

21 January 2018

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21 January 2018

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21 January 2018

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Transport of arylsulfatase A across the blood-brain barrier in vitro

21 January 2018

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Enzyme replacement improves nervous system pathology and function in a mouse model for metachromatic leukodystrophy

21 January 2018

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Enzyme replacement improves ataxic gait and central nervous system histopathology in a mouse model of metachromatic leukodystrophy

21 January 2018

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21 January 2018

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Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier

21 January 2018

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Immunologic privilege in the central nervous system and the blood-brain barrier

21 January 2018

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In vitro blood-brain barrier models: current and perspective technologies

21 January 2018

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A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

21 January 2018

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Mechanisms of disease: the blood-brain barrier

21 January 2018

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Engaging neuroscience to advance translational research in brain barrier biology.

21 January 2018

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Structure and Function of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)

21 January 2018

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Identification of proline residues in or near the transmembrane helices of the human breast cancer resistance protein (BCRP/ABCG2) that are important for transport activity and substrate specificity

21 January 2018

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21 January 2018

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Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development

21 January 2018

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Medicinal chemical properties of successful central nervous system drugs

21 January 2018

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Substrate reduction therapy

21 January 2018

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Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

21 January 2018

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The anatomical and cellular basis of immune surveillance in the central nervous system.

21 January 2018

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Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences

21 January 2018

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Addressing central nervous system (CNS) penetration in drug discovery: basics and implications of the evolving new concept

21 January 2018

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Trans-generational exposure to low levels of rhodamine B does not adversely affect litter size or liver function in murine mucopolysaccharidosis type IIIA.

21 January 2018

1 reference

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The blood-brain barrier is disrupted in a mouse model of infantile neuronal ceroid lipofuscinosis: amelioration by resveratrol

21 January 2018

1 reference

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Barrier mechanisms in the developing brain.

21 January 2018

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Therapeutic approaches for neuronopathic lysosomal storage disorders

21 January 2018

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Clarifying lysosomal storage diseases

21 January 2018

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Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease

21 January 2018

1 reference

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Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Endothelial transcytosis in health and disease

21 January 2018

1 reference

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Transport of interleukin-1 across cerebromicrovascular endothelial cells

21 January 2018

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Targeted delivery of proteins across the blood-brain barrier

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Relocalization of junctional adhesion molecule A during inflammatory stimulation of brain endothelial cells.

21 January 2018

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Pathophysiology of the neurovascular unit: disease cause or consequence?

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Gene therapy approaches for lysosomal storage disorders, a good model for the treatment of mendelian diseases

21 January 2018

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Physicochemical selectivity of the BBB microenvironment governing passive diffusion--matching with a porcine brain lipid extract artificial membrane permeability model

21 January 2018

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Delivery of drugs to the brain via the blood brain barrier using colloidal carriers

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Developmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrier

21 January 2018

1 reference

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Modelling the neurovascular unit and the blood-brain barrier with the unique function of pericytes.

21 January 2018

1 reference

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The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls

21 January 2018

1 reference

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The role of inflammation in epilepsy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Gene therapy augments the efficacy of hematopoietic cell transplantation and fully corrects mucopolysaccharidosis type I phenotype in the mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Common and uncommon pathogenic cascades in lysosomal storage diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Contribution of brain inflammation to neuronal cell death in neuronopathic forms of Gaucher's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Overcoming the blood-brain barrier with high-dose enzyme replacement therapy in murine mucopolysaccharidosis VII.

21 January 2018

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Diphtheria toxin mutant CRM197-mediated transcytosis across blood-brain barrier in vitro

21 January 2018

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Central nervous system pericytes in health and disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis

21 January 2018

1 reference

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Tanycytes and pituicytes: morphological and functional aspects of neuroglial interaction

21 January 2018

1 reference

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Structure-activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion

21 January 2018

1 reference

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Neurovascular mechanisms of Alzheimer's neurodegeneration

21 January 2018

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Investigation on mechanisms of glycopeptide nanoparticles for drug delivery across the blood–brain barrier

21 January 2018

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Establishment of a simplified in vitro porcine blood-brain barrier model with high transendothelial electrical resistance

21 January 2018

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12 December 2020

Neurodegeneration and the neurovascular unit

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12 December 2020

Absence of albumin receptor on brain capillaries in vivo or in vitro

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12 December 2020

Structural and functional aspects of the blood-brain barrier.

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12 December 2020

In vitro models of the blood-brain barrier

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12 December 2020

A combined artificial chromosome-stem cell therapy method in a model experiment aimed at the treatment of Krabbe’s disease in the Twitcher mouse

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12 December 2020

Intracerebroventricular enzyme infusion corrects central nervous system pathology and dysfunction in a mouse model of metachromatic leukodystrophy

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12 December 2020

Overview and introduction: the blood-brain barrier in health and disease

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12 December 2020

In vitro models of the blood-brain barrier

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12 December 2020

Human ABC transporters ABCG2 (BCRP) and ABCG4

1 reference

12 December 2020

Spatial and temporal correlation between neuron loss and neuroinflammation in a mouse model of neuronopathic Gaucher disease

1 reference

12 December 2020

The impact of pericytes on the blood-brain barrier integrity depends critically on the pericyte differentiation stage

1 reference

12 December 2020

Insulin-like growth factors cross the blood-brain barrier

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12 December 2020

Generation of a set of simple, interpretable ADMET rules of thumb

1 reference

12 December 2020

Apical-to-basolateral transport of amyloid-β peptides through blood-brain barrier cells is mediated by the receptor for advanced glycation end-products and is restricted by P-glycoprotein

1 reference

12 December 2020

Prediction of blood-brain barrier penetration: are we missing the point?

1 reference

12 December 2020

Elevated expression of glucose transporter-1 in hypothalamic ependymal cells not involved in the formation of the brain-cerebrospinal fluid barrier

1 reference

12 December 2020

The flexibility of P-glycoprotein for its poly-specific drug binding from molecular dynamics simulations

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12 December 2020

A review of blood-brain barrier transport techniques

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12 December 2020

An overview of in vitro techniques for blood-brain barrier studies

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12 December 2020

Prediction of blood-brain barrier permeation in drug discovery from in vivo, in vitro and in silico models

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12 December 2020

Intracisternal enzyme replacement therapy in lysosomal storage diseases: routes of absorption into brain

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12 December 2020

Theranostic liposomes loaded with quantum dots and apomorphine for brain targeting and bioimaging

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12 December 2020

Receptor-mediated transcytosis of transferrin through blood-brain barrier endothelial cells.

1 reference

12 December 2020

New strategies for the treatment of lysosomal storage diseases (review).

1 reference

12 December 2020

10.1007/S10545-013-9608-0

Identifiers

DOI

1 reference

Dimensions Publication ID

28 August 2017

1039653833

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