Molecular players in neutrophil chemotaxis--focus on PI3K and small GTPases (Q38106011)

28 August 2017

title

Molecular players in neutrophil chemotaxis--focus on PI3K and small GTPases (English)

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28 August 2017

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Sonja Vermeren

2

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author name string

Laure Gambardella

series ordinal

1

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28 August 2017

publication date

10 May 2013

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Journal of Leukocyte Biology

28 August 2017

published in

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28 August 2017

volume

94

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28 August 2017

issue

4

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28 August 2017

page(s)

603-612

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Neutrophils and immunity: challenges and opportunities

28 August 2017

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A novel optical assay system for the quantitative measurement of chemotaxis

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Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo.

21 January 2018

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Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo.

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PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils

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PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP.

21 January 2018

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An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients

21 January 2018

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A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis

21 January 2018

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Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis

21 January 2018

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Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

21 January 2018

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Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

21 January 2018

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Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis

21 January 2018

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Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement

21 January 2018

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Mechanisms and implications of phosphoinositide 3-kinase delta in promoting neutrophil trafficking into inflamed tissue.

21 January 2018

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PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis

21 January 2018

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Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions.

21 January 2018

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PI3-kinase signaling contributes to orientation in shallow gradients and enhances speed in steep chemoattractant gradients.

21 January 2018

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Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish

21 January 2018

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Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis

21 January 2018

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Regulation of PTEN by Rho small GTPases

21 January 2018

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Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions

21 January 2018

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Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation

21 January 2018

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Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis.

21 January 2018

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21 January 2018

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GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kγ activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production

21 January 2018

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21 January 2018

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Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains

21 January 2018

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Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.

21 January 2018

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Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through β2 integrin activation

21 January 2018

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Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

21 January 2018

1 reference

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Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

P-Rex1 regulates neutrophil function

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses

21 January 2018

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Vav GEFs are required for beta2 integrin-dependent functions of neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Vav1 is essential for mechanotactic crawling and migration of neutrophils out of the inflamed microvasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.1112564

DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.1112564

Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.

21 January 2018

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Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma

21 January 2018

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The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.1112564

Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.1112564

Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules

21 January 2018

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Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.1112564

WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.1112564

Spatiotemporal dynamics of RhoA activity in migrating cells

21 January 2018

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Coordination of Rho GTPase activities during cell protrusion

21 January 2018

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Multiple roles for RhoA during T cell transendothelial migration

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.1112564

Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.1112564

Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism

21 January 2018

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mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.1112564

Integrin-induced PIP5K1C kinase polarization regulates neutrophil polarization, directionality, and in vivo infiltration

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.1112564

Activation of Rhoa and ROCK are essential for detachment of migrating leukocytes

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.1112564

RhoA is required for monocyte tail retraction during transendothelial migration

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.1112564

Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.1112564

Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion

21 January 2018

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The mDial formin is required for neutrophil polarization, migration, and activation of the LARG/RhoA/ROCK signaling axis during chemotaxis

21 January 2018

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Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices

21 January 2018

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Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3.

21 January 2018

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Neutrophil Functions and Autoimmune Arthritis in the Absence of p190RhoGAP: Generation and Analysis of a Novel Null Mutation in Mice

21 January 2018

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Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1.

21 January 2018

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Hax1 regulates neutrophil adhesion and motility through RhoA.

21 January 2018

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A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues

21 January 2018

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How cells integrate complex stimuli: the effect of feedback from phosphoinositides and cell shape on cell polarization and motility

21 January 2018

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Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration

21 January 2018

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A local coupling model and compass parameter for eukaryotic chemotaxis.

21 January 2018

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Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour

21 January 2018

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Network crosstalk dynamically changes during neutrophil polarization.

21 January 2018

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Chemotaxis in the Absence of PIP3 Gradients

21 January 2018

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ARAP3 is a PI3K- and rap-regulated GAP for RhoA

21 January 2018

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21 January 2018

Identifiers

DOI

10.1189/JLB.1112564

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28 August 2017

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