Germinal center B and follicular helper T cells: siblings, cousins or just good friends? (Q37899118)

25 August 2017

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title

Germinal center B and follicular helper T cells: siblings, cousins or just good friends? (English)

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25 August 2017

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Stephen L Nutt

1

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PubMed ID

21739669

25 August 2017

David M Tarlinton

series ordinal

2

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PubMed ID

21739669

25 August 2017

language of work or name

English

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publication date

1 June 2011

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25 August 2017

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25 August 2017

12

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25 August 2017

472-477

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25 August 2017

6

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Clonal selection and learning in the antibody system

25 August 2017

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Plasma cell development: from B-cell subsets to long-term survival niches.

21 January 2018

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B-cell memory: are subsets necessary?

21 January 2018

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Plasticity and heterogeneity in the generation of memory B cells and long-lived plasma cells: the influence of germinal center interactions and dynamics.

21 January 2018

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Germinal-center organization and cellular dynamics

21 January 2018

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Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs

21 January 2018

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Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts.

21 January 2018

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Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles

21 January 2018

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Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization.

21 January 2018

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Follicular helper T cells: lineage and location

21 January 2018

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Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation.

21 January 2018

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B cell follicles and antigen encounters of the third kind

21 January 2018

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Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.

21 January 2018

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Dissecting affinity maturation: a model explaining selection of antibody-forming cells and memory B cells in the germinal centre.

21 January 2018

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Plasma cells negatively regulate the follicular helper T cell program

21 January 2018

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Pax5: the guardian of B cell identity and function

21 January 2018

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The regulation of the B-cell gene expression programme by Pax5.

21 January 2018

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Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells

21 January 2018

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Regulation of plasma-cell development

21 January 2018

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Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.

21 January 2018

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BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis

21 January 2018

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The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

21 January 2018

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Control of inflammation, cytokine expression, and germinal center formation by BCL-6

21 January 2018

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Disruption of the Bcl6 gene results in an impaired germinal center formation

21 January 2018

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The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.

21 January 2018

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Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells.

21 January 2018

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BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

21 January 2018

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Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation

21 January 2018

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IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

21 January 2018

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IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism

21 January 2018

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A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma.

21 January 2018

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The transcriptional programme of antibody class switching involves the repressor Bach2.

21 January 2018

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Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function.

21 January 2018

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Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch

21 January 2018

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Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors

21 January 2018

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Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1.

21 January 2018

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B cell development and immunoglobulin gene transcription in the absence of Oct-2 and OBF-1.

21 January 2018

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Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein

21 January 2018

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EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis

21 January 2018

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Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells

21 January 2018

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Repression of BCL-6 is required for the formation of human memory B cells in vitro

21 January 2018

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The elusive identity of T follicular helper cells

21 January 2018

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CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function

21 January 2018

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Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production

21 January 2018

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Bcl6 mediates the development of T follicular helper cells

21 January 2018

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Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation

21 January 2018

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The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment.

21 January 2018

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Inhibition of Th2 differentiation and GATA-3 expression by BCL-6

21 January 2018

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Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses

21 January 2018

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Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

21 January 2018

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A fundamental role for interleukin-21 in the generation of T follicular helper cells

21 January 2018

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A nonredundant role for IL-21 receptor signaling in plasma cell differentiation and protective type 2 immunity against gastrointestinal helminth infection

21 January 2018

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IL-21 receptor is critical for the development of memory B cell responses.

21 January 2018

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The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

21 January 2018

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Regulation of the IL-21 gene by the NF-κB transcription factor c-Rel

21 January 2018

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SLAM family receptors and SAP adaptors in immunity.

21 January 2018

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T cells and follicular dendritic cells in germinal center B-cell formation and selection.

21 January 2018

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IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells.

21 January 2018

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Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)

21 January 2018

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IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells

21 January 2018

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Cytokine-secreting follicular T cells shape the antibody repertoire

21 January 2018

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PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

21 January 2018

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Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

21 January 2018

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Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84.

21 January 2018

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Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation.

21 January 2018

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Imaging of germinal center selection events during affinity maturation

21 January 2018

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Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns.

21 January 2018

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In vivo imaging of germinal centres reveals a dynamic open structure

21 January 2018

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Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter

21 January 2018

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In vivo control of B-cell survival and antigen-specific B-cell responses

21 January 2018

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Two waves of memory B-cell generation in the primary immune response.

21 January 2018

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Progressive differentiation and selection of the fittest in the immune response

21 January 2018

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bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells

21 January 2018

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

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BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs

21 January 2018

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Mcl-1 is essential for germinal center formation and B cell memory

21 January 2018

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Human IgM+CD27+ B cells: memory B cells or "memory" B cells?

21 January 2018

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Multiple layers of B cell memory with different effector functions

21 January 2018

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Different B cell populations mediate early and late memory during an endogenous immune response

21 January 2018

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The roles of gamma 1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses.

21 January 2018

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Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory.

21 January 2018

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Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched B cells

21 January 2018

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Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors

21 January 2018

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Intrinsic properties of immunoglobulin IgG1 isotype-switched B cell receptors promote microclustering and the initiation of signaling

21 January 2018

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The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor

21 January 2018

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Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses

21 January 2018

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12 December 2020

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12 December 2020

Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function

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12 December 2020

EBI2 mediates B cell segregation between the outer and centre follicle

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12 December 2020

Give and take in the germinal center

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12 December 2020

Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation

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12 December 2020

Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance

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12 December 2020

Blimp-1 attenuates Th1 differentiation by repression of ifng, tbx21, and bcl6 gene expression

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12 December 2020

Visualization of specific B and T lymphocyte interactions in the lymph node.

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12 December 2020

Identifiers

DOI

10.1038/NI.2019

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25 August 2017

1 reference

PubMed ID

21739669