Genetic insights into common pathways and complex relationships among immune-mediated diseases (Q38126785)

29 August 2017

Genetic insights into common pathways and complex relationships among immune-mediated diseases (English)

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29 August 2017

4

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29 August 2017

David A van Heel

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author name string

Miles Parkes

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1

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PubMed ID

23917628

29 August 2017

Adrian Cortes

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2

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29 August 2017

6 August 2013

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29 August 2017

Nature Reviews Genetics

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29 August 2017

14

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29 August 2017

661-673

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29 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrg3502

29 August 2017

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cites work

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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

21 January 2018

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21 January 2018

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A common genetic background for inflammatory bowel disease and ankylosing spondylitis: a genealogic study in Iceland

21 January 2018

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Five years of GWAS discovery

21 January 2018

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High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

21 January 2018

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Bayesian refinement of association signals for 14 loci in 3 common diseases

21 January 2018

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Annotation of functional variation in personal genomes using RegulomeDB

21 January 2018

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Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.

21 January 2018

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Elucidating the chromosome 9 association with AS; CARD9 is a candidate gene

21 January 2018

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Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

21 January 2018

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Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

21 January 2018

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Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes

21 January 2018

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Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

21 January 2018

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Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

21 January 2018

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Insulin gene mutations as a cause of permanent neonatal diabetes

21 January 2018

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CARD15 mutations in Blau syndrome

21 January 2018

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Inflammatory bowel disease and mutations affecting the interleukin-10 receptor

21 January 2018

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Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

21 January 2018

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Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis

21 January 2018

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Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

21 January 2018

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Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

21 January 2018

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Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.

21 January 2018

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The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases

21 January 2018

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The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis

21 January 2018

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Ankylosing spondylitis and HL-A 27.

21 January 2018

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Human Lymphocyte Antigen Association in Ankylosing Spondylitis

21 January 2018

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High Association of an HL-A Antigen, W27, with Ankylosing Spondylitis

21 January 2018

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A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis

21 January 2018

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Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

21 January 2018

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Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

21 January 2018

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Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis

21 January 2018

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The intricate role of complement component C4 in human systemic lupus erythematosus

21 January 2018

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A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

21 January 2018

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A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes

21 January 2018

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A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis

21 January 2018

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Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor

21 January 2018

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Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions

21 January 2018

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A20: linking a complex regulator of ubiquitylation to immunity and human disease

21 January 2018

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A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis.

21 January 2018

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Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis.

21 January 2018

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B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice

21 January 2018

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IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

21 January 2018

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IRF8 mutations and human dendritic-cell immunodeficiency

21 January 2018

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A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

21 January 2018

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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

21 January 2018

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Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation

21 January 2018

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Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

21 January 2018

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A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis

21 January 2018

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Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.

21 January 2018

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A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

21 January 2018

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The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness.

21 January 2018

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Defective acute inflammation in Crohn's disease: a clinical investigation

21 January 2018

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TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

21 January 2018

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Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

21 January 2018

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Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome

21 January 2018

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A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

21 January 2018

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

21 January 2018

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 January 2018

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Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

21 January 2018

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Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

21 January 2018

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Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

21 January 2018

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Association of the TSHR gene with Graves' disease: the first disease specific locus.

21 January 2018

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Genetically distinct subsets within ANCA-associated vasculitis

21 January 2018

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Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis

21 January 2018

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Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis.

21 January 2018

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Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke

21 January 2018

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A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis

21 January 2018

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Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis

21 January 2018

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Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis

21 January 2018

1 reference

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

21 January 2018

1 reference

Reduced expression of IFIH1 is protective for type 1 diabetes

21 January 2018

1 reference

Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production

21 January 2018

1 reference

Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo

21 January 2018

1 reference

Multiple common variants for celiac disease influencing immune gene expression

21 January 2018

1 reference

The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans

21 January 2018

1 reference

Finding the missing heritability of complex diseases

21 January 2018

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Common SNPs explain a large proportion of the heritability for human height

21 January 2018

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Discovery of common Asian copy number variants using integrated high-resolution array CGH and massively parallel DNA sequencing

21 January 2018

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Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis

21 January 2018

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Finding the sources of missing heritability in a yeast cross

21 January 2018

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Chromatin marks identify critical cell types for fine mapping complex trait variants

21 January 2018

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Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles

21 January 2018

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An integrated encyclopedia of DNA elements in the human genome

21 January 2018

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Promise and pitfalls of the Immunochip

21 January 2018

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Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1

21 January 2018

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The role of IL-17-secreting mast cells in inflammatory joint disease

21 January 2018

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Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection

21 January 2018

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Familial clustering of rheumatoid arthritis with other autoimmune diseases

21 January 2018

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Shared familial aggregation of susceptibility to autoimmune diseases

31 March 2020

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Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial

31 March 2020

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Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate

31 March 2020

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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

31 March 2020

1 reference

Estimation of effect size distribution from genome-wide association studies and implications for future discoveries

31 March 2020

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HL-A antigens in psoriasis with special reference to the clinical type, age of onset, exacerbations after respiratory infections and occurrence of arthritis

31 March 2020

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12 December 2020

Behçet disease and the HLA system

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12 December 2020

Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families.

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12 December 2020

Genetic interrelationship between insulin-dependent diabetes mellitus, the autoimmune thyroid diseases, and rheumatoid arthritis

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12 December 2020

Identifiers

DOI

10.1038/NRG3502

1 reference

PubMed ID

23917628

Dimensions Publication ID

29 August 2017

0 references

1 reference

PubMed ID

23917628