Can parkin be a target for future treatment of Parkinson's disease? (Q38127703)

29 August 2017

Can parkin be a target for future treatment of Parkinson's disease? (English)

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29 August 2017

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4

Nobutaka Hattori

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29 August 2017

Shin-Ichiro Kubo

1

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29 August 2017

Taku Hatano

series ordinal

2

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29 August 2017

Masashi Takanashi

series ordinal

3

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29 August 2017

language of work or name

English

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publication date

9 August 2013

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Expert Opinion on Therapeutic Targets

29 August 2017

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29 August 2017

17

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29 August 2017

10

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29 August 2017

1133-1144

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The genetics of Parkinson disease

29 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Mitochondrial complex I deficiency in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Iron-melanin interaction and lipid peroxidation: implications for Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Oxidative stress in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

The genetics of Parkinson disease: Implications for neurological care

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Recessive Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Pathogenesis of familial Parkinson's disease: new insights based on monogenic forms of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Paralysis agitans of early onset with marked diurnal fluctuation of symptoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Association between early-onset Parkinson's disease and mutations in the parkin gene

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.827173

How much phenotypic variation can be attributed to parkin genotype?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Clinical and pathologic abnormalities in a family with parkinsonism and parkin gene mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Steele-Richardson-Olszewski syndrome in a patient with a single C212Y mutation in the parkin protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin disease: a phenotypic study of a large case series

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin mutations are frequent in patients with isolated early-onset parkinsonism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin variants in North American Parkinson's disease: cases and controls.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

The neuropathology of genetic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Familial juvenile parkinsonism: clinical and pathologic study in a family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Autosomal recessive parkinsonism linked to parkin gene in a Tunisian family. Clinical, genetic and pathological study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Genotype-phenotype correlation: familial Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Lewy bodies and parkinsonism in families with parkin mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Lewy body pathology in a patient with a homozygous parkin deletion

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin is associated with cellular vesicles

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.827173

SEPT5_v2 is a parkin-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Pathogenetic mechanisms of parkin in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin genetics: one model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

The ubiquitin system for protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Monoubiquitin carries a novel internalization signal that is appended to activated receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Protein regulation by monoubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Receptor downregulation and multivesicular-body sorting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Autoregulation of Parkin activity through its ubiquitin-like domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Loss of locus coeruleus neurons and reduced startle in parkin null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Decline of striatal dopamine release in parkin-deficient mice shown by ex vivo autoradiography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin-deficient mice are not a robust model of parkinsonism

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Linear ubiquitination: a newly discovered regulator of cell signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Common anti-apoptotic roles of parkin and alpha-synuclein in human dopaminergic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Comment on "S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function".

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Dopamine covalently modifies and functionally inactivates parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Sulfhydration mediates neuroprotective actions of parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Advances in gene therapy for movement disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

6-Hydroxydopamine increases ubiquitin-conjugates and protein degradation: implications for the pathogenesis of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

DJ-1 and Parkin Modulate Dopamine-dependent Behavior and Inhibit MPTP-induced Nigral Dopamine Neuron Loss in Mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin-mediated protection of dopaminergic neurons in a chronic MPTP-minipump mouse model of Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Parkin gene therapy for alpha-synucleinopathy: a rat model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Neuronal specificity of alpha-synuclein toxicity and effect of Parkin co-expression in primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

alpha-Synuclein gene duplication is present in sporadic Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

Genome-wide linkage analysis and evidence of gene-by-gene interactions in a sample of 362 multiplex Parkinson disease families

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

A Di-leucine Signal in the Ubiquitin Moiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.827173

10.1517/14728222.2013.827173

21 January 2018

Identifiers

DOI

1 reference

29 August 2017

1 reference