Phenotypic screens targeting neurodegenerative diseases (Q38130052)

29 August 2017

title

Phenotypic screens targeting neurodegenerative diseases (English)

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29 August 2017

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Minhua Zhang

1

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29 August 2017

Guangrui Luo

2

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29 August 2017

Yanjiao Zhou

3

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29 August 2017

Shaohui Wang

4

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29 August 2017

Zhong Zhong

5

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29 August 2017

publication date

19 August 2013

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Journal of Biomolecular Screening

29 August 2017

published in

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29 August 2017

volume

19

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29 August 2017

issue

1

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29 August 2017

page(s)

1-16

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Ageing and Parkinson's disease: substantia nigra regional selectivity

29 August 2017

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Role of mendelian genes in "sporadic" Parkinson's disease

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Levodopa-induced dyskinesias and their management.

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New and emerging treatments for Alzheimer's disease.

21 January 2018

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Priorities in Parkinson's disease research

21 January 2018

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Harnessing the power of the genome in the search for new antibiotics

21 January 2018

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How were new medicines discovered?

21 January 2018

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Genomics and drugs. An interview conducted by Holger Breithaupt and Caroline Hadley

21 January 2018

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New technologies for high-throughput screening

21 January 2018

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11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

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2012: A watershed year for Alzheimer's disease research

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Antiepileptic drug therapy the story so far

21 January 2018

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Phenotypic Screening Strategies for Neurodegenerative Diseases: A Pathway to Discover Novel Drug Candidates and Potential Disease Targets or Mechanisms

21 January 2018

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Cellular models to investigate biochemical pathways in Parkinson's disease

21 January 2018

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High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model

21 January 2018

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Drug library screen to identify compounds that decrease secreted Abeta from a human cell line

21 January 2018

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The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau.

21 January 2018

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An in vitro screening cascade to identify neuroprotective antioxidants in ALS

21 January 2018

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Anti-inflammatory effects of synthetic compound KT-14480 in lipopolysaccharide-stimulated microglia cells

21 January 2018

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An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicity

21 January 2018

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

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Protein aggregation and neurodegenerative disease

21 January 2018

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Alzheimer's disease is a synaptic failure

21 January 2018

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Memory and mental status correlates of modified Braak staging.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113499777

Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113499777

Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Oxidative damage is the earliest event in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Identification of small molecule inhibitors of beta-amyloid cytotoxicity through a cell-based high-throughput screening platform

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

A cell-based model of alpha-synucleinopathy for screening compounds with therapeutic potential of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Development of a high-throughput screening assay for cytoprotective agents in rotenone-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

A yeast-based model of alpha-synucleinopathy identifies compounds with therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Chemicals possessing a neurotrophin-like activity on dopaminergic neurons in primary culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Caenorhabditis elegans MPP+ model of Parkinson's disease for high-throughput drug screenings

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

A chemical screen identifies novel compounds that overcome glial-mediated inhibition of neuronal regeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Prevention of β-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Neuroprotection of MPTP-induced toxicity in zebrafish dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Brain-derived neurotrophic factor and Alzheimer's disease: physiopathology and beyond

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113499777

Neurotrophic factors as a therapeutic target for Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113499777

Central nervous system remyelination in culture--a tool for multiple sclerosis research

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113499777

Stem cell therapy for human neurodegenerative disorders-how to make it work

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113499777

Translating stem cell studies to the clinic for CNS repair: current state of the art and the need for a Rosetta stone

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113499777

Adult neurogenesis in the mammalian central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

A chemical genomics screen to discover genes that modulate neural stem cell differentiation

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113499777

A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113499777

A small molecule accelerates neuronal differentiation in the adult rat.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113499777

A high-throughput screen for Wnt/β-catenin signaling pathway modulators in human iPSC-derived neural progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Discovery of a proneurogenic, neuroprotective chemical

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Identification of modulators of hair cell regeneration in the zebrafish lateral line

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Going further than Lipinski's rule in drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

The influence of the 'organizational factor' on compound quality in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

ZINC--a free database of commercially available compounds for virtual screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

What's wrong with drug screening today

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Pathologic lesions in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Induced pluripotent stem cells from a spinal muscular atrophy patient

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Disease modeling and drug screening for neurological diseases using human induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Cytometric assessment of mitochondria using fluorescent probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Fluorescent and luminescent probes for detection of reactive oxygen and nitrogen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Multiparameter measurement of caspase 3 activation and apoptotic cell death in NT2 neuronal precursor cells using high-content analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Creation of engineered human embryonic stem cell lines using phiC31 integrase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Generation of induced pluripotent stem cells using site-specific integration with phage integrase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Composite primary neuronal high-content screening assay for Huntington's disease incorporating non-cell-autonomous interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Quantifying amyloid beta (Aβ)-mediated changes in neuronal morphology in primary cultures: implications for phenotypic screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

An overview of cell phenotypes in HCS: limitations and advantages

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Finding promiscuous old drugs for new uses

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Adenosine signaling promotes regeneration of pancreatic β cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Target deconvolution strategies in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Chemoproteomic approaches to drug target identification and drug profiling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Chemical genetics-based target identification in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Synthetic small molecules that control stem cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Diverse small-molecule modulators of SMN expression found by high-throughput compound screening: early leads towards a therapeutic for spinal muscular atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

DcpS as a therapeutic target for spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Identifying the proteins to which small-molecule probes and drugs bind in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Identifying cellular targets of small-molecule probes and drugs with biochemical enrichment and SILAC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113499777

Applications of Connectivity Map in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

A chemical genetic approach identifies piperazine antipsychotics as promoters of CNS neurite growth on inhibitory substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Discovery and development of SAHA as an anticancer agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113499777

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells

21 January 2018

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/NATURE10821

Identifiers

DOI

10.1177/1087057113499777

1 reference

release_z76qvyq3ojbbvgpehmzbzq6oie

29 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/z76qvyq3ojbbvgpehmzbzq6oie

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference