BMP growth factor signaling in a biomechanical context (Q38152403)

29 August 2017

BMP growth factor signaling in a biomechanical context (English)

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29 August 2017

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5

Petra Knaus

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Christian Hiepen

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object named as

Christian Hiepen

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author name string

Jessica Kopf

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29 August 2017

Pia Paarmann

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29 August 2017

Christian Hiepen

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29 August 2017

Daniel Horbelt

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29 August 2017

Petra Knaus

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29 August 2017

4 October 2013

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29 August 2017

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29 August 2017

40

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29 August 2017

2

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29 August 2017

171-187

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Bone: formation by autoinduction

29 August 2017

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Tgf-beta superfamily signaling in embryonic development and homeostasis

21 January 2018

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A portrait of Transforming Growth Factor β superfamily signalling: Background matters

21 January 2018

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Spatial regulation of BMP activity

21 January 2018

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Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists

21 January 2018

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Promiscuity and specificity in BMP receptor activation

21 January 2018

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A large bioactive BMP ligand with distinct signaling properties is produced by alternative proconvertase processing

21 January 2018

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Fine-tuned shuttles for bone morphogenetic proteins

21 January 2018

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Comparative Genomic Analysis of the Eight-Membered Ring Cystine Knot-Containing Bone Morphogenetic Protein Antagonists

21 January 2018

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Novel functions of Noggin proteins: inhibition of Activin/Nodal and Wnt signaling.

21 January 2018

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A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling

21 January 2018

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BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation

21 January 2018

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Angiopoietin-1 mediates the proangiogenic activity of the bone morphogenic protein antagonist Drm

21 January 2018

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Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation

21 January 2018

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Targeting of bone morphogenetic protein growth factor complexes to fibrillin

21 January 2018

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Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling

21 January 2018

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The identification of a heparin binding domain peptide from bone morphogenetic protein-4 and its role on osteogenesis.

21 January 2018

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Multistep molecular mechanism for bone morphogenetic protein extracellular transport in the Drosophila embryo

21 January 2018

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Receptor oligomerization and beyond: a case study in bone morphogenetic proteins

21 January 2018

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BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors

21 January 2018

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The signaling and functions of heterodimeric bone morphogenetic proteins

21 January 2018

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Recent advances in BMP receptor signaling

21 January 2018

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Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors

21 January 2018

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The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways.

21 January 2018

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Homomeric and heteromeric complexes among TGF-β and BMP receptors and their roles in signaling

21 January 2018

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SMAD versus non-SMAD signaling is determined by lateral mobility of bone morphogenetic protein (BMP) receptors

21 January 2018

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Different routes of bone morphogenic protein (BMP) receptor endocytosis influence BMP signaling

21 January 2018

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Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling

21 January 2018

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Spatial segregation of BMP/Smad signaling affects osteoblast differentiation in C2C12 cells

21 January 2018

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Initiation of BMP2 signaling in domains on the plasma membrane.

21 January 2018

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Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2.

21 January 2018

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Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning

21 January 2018

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Spatial restriction of bone morphogenetic protein signaling in mouse gastrula through the mVam2-dependent endocytic pathway.

21 January 2018

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Smad transcription factors

21 January 2018

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How the Smads regulate transcription

21 January 2018

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TGFβ signalling in context

21 January 2018

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Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes

21 January 2018

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Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal

21 January 2018

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Integration of BMP and Wnt signaling via vertebrate Smad1/5/8 and Drosophila Mad.

21 January 2018

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Phosphatases in SMAD regulation

21 January 2018

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PP2A regulates BMP signalling by interacting with BMP receptor complexes and by dephosphorylating both the C-terminus and the linker region of Smad1.

21 January 2018

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21 January 2018

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Mechanotransduction in osteoblast regulation and bone disease

21 January 2018

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Mechanotransduction in vascular physiology and atherogenesis

21 January 2018

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Mechanotransduction in skeletal muscle

21 January 2018

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Environmental sensing through focal adhesions

21 January 2018

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Local force and geometry sensing regulate cell functions

21 January 2018

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Growth factors, matrices, and forces combine and control stem cells

21 January 2018

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Matrix elasticity directs stem cell lineage specification

21 January 2018

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Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate.

21 January 2018

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Balancing forces: architectural control of mechanotransduction

21 January 2018

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Signalling through mechanical inputs: a coordinated process

21 January 2018

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Tissue cells feel and respond to the stiffness of their substrate

21 January 2018

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Dynamic molecular processes mediate cellular mechanotransduction

21 January 2018

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Mechanotransduction involving multimodular proteins: converting force into biochemical signals

21 January 2018

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Mechanotransduction at cadherin-mediated adhesions.

21 January 2018

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Mechanotransduction gone awry

21 January 2018

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Molecular control of endothelial cell behaviour during blood vessel morphogenesis

21 January 2018

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The nucleoskeleton as a genome-associated dynamic 'network of networks'.

21 January 2018

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Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

21 January 2018

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More than a feeling: discovering, understanding, and influencing mechanosensing pathways

21 January 2018

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Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling.

21 January 2018

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Mechanosensitive mechanisms in transcriptional regulation

21 January 2018

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The mechanobiology of brain function

21 January 2018

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Bone morphogenetic protein signalling and vertebrate nervous system development

21 January 2018

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Systems control of BMP morphogen flow in vertebrate embryos

21 January 2018

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The preplacodal region: an ectodermal domain with multipotential progenitors that contribute to sense organs and cranial sensory ganglia.

21 January 2018

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Mechanical control of tissue and organ development

21 January 2018

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Mechanotransduction in development: a growing role for contractility

21 January 2018

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Evidence for tension-based regulation of Drosophila MAL and SRF during invasive cell migration

21 January 2018

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Tissue deformation modulates twist expression to determine anterior midgut differentiation in Drosophila embryos.

21 January 2018

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Mechanical induction of Twist in the Drosophila foregut/stomodeal primordium

21 January 2018

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A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator

21 January 2018

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The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

21 January 2018

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Hippo pathway regulation by cell morphology and stress fibers.

21 January 2018

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Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways

21 January 2018

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A tense situation: forcing tumour progression

21 January 2018

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Mechanics, malignancy, and metastasis: the force journey of a tumor cell

21 January 2018

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Matrix crosslinking forces tumor progression by enhancing integrin signaling

21 January 2018

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The physics of cancer: the role of physical interactions and mechanical forces in metastasis

21 January 2018

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Biomechanical forces shape the tumor microenvironment.

21 January 2018

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Latent TGF-β structure and activation

21 January 2018

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Role of transforming growth factor-beta superfamily signaling pathways in human disease

21 January 2018

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Beyond TGFβ: roles of other TGFβ superfamily members in cancer

21 January 2018

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A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva

21 January 2018

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TGF-β and BMP signaling in osteoblast differentiation and bone formation

21 January 2018

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BMP2 signaling in bone development and repair

21 January 2018

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Developmental regulation of the growth plate

21 January 2018

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Multiple functions of BMPs in chondrogenesis

21 January 2018

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Genetic control of bone formation

21 January 2018

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Regulation of bone and cartilage development by network between BMP signalling and transcription factors

21 January 2018

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Critical molecular switches involved in BMP-2-induced osteogenic differentiation of mesenchymal cells

21 January 2018

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Bone's mechanostat: A 2003 update

21 January 2018

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Mechanical signals as anabolic agents in bone

21 January 2018

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Boning up on Wolff's Law: mechanical regulation of the cells that make and maintain bone

21 January 2018

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Signal transduction pathways involved in mechanotransduction in bone cells

21 January 2018

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The role of endogenous bone morphogenetic proteins in normal skeletal repair.

21 January 2018

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Bone morphogenetic proteins in clinical applications

21 January 2018

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Mechanotransduction and fracture repair

21 January 2018

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Mechanics and mechano-biology of fracture healing in normal and osteoporotic bone.

21 January 2018

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The course of bone healing is influenced by the initial shear fixation stability.

21 January 2018

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Mechanical load modulates the stimulatory effect of BMP2 in a rat nonunion model

21 January 2018

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Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo

21 January 2018

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Emerging role of bone morphogenetic proteins in angiogenesis

21 January 2018

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Signaling by members of the TGF-beta family in vascular morphogenesis and disease

21 January 2018

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Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades

21 January 2018

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Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells.

21 January 2018

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BMP signaling in vascular diseases

21 January 2018

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Neural guidance molecules, tip cells, and mechanical factors in vascular development

21 January 2018

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Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives

21 January 2018

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Endothelial mechanosensors of shear stress as regulators of atherogenesis

21 January 2018

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Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell

21 January 2018

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Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature.

21 January 2018

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Mechanotransduction of shear in the endothelium: basic studies and clinical implications

21 January 2018

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Force-specific activation of Smad1/5 regulates vascular endothelial cell cycle progression in response to disturbed flow

21 January 2018

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Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries

21 January 2018

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Cellular and molecular mechanisms of thoracic aortic aneurysms

21 January 2018

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Secretory functions of smooth muscle: cytokines and growth factors

21 January 2018

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Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activity

21 January 2018

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Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction

21 January 2018

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Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation

21 January 2018

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Regulation of matrix metalloproteinase gene expression

21 January 2018

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TGF-beta signaling in vascular biology and dysfunction

21 January 2018

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The molecular genetics of Marfan syndrome and related disorders

21 January 2018

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Bone morphogenetic proteins in vascular calcification

21 January 2018

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Deconstructing the third dimension: how 3D culture microenvironments alter cellular cues

21 January 2018

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Controlled spatial and conformational display of immobilised bone morphogenetic protein-2 and osteopontin signalling motifs regulates osteoblast adhesion and differentiation in vitro

21 January 2018

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Presentation of BMP-2 from a soft biopolymeric film unveils its activity on cell adhesion and migration.

21 January 2018

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The performance of BMP-2 loaded TCP/HAP porous ceramics with a polyelectrolyte multilayer film coating.

21 January 2018

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Synergistic control of mesenchymal stem cell differentiation by nanoscale surface geometry and immobilized growth factors on TiO2 nanotubes.

21 January 2018

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Differentiation of pre-osteoblast cells on poly(ethylene terephthalate) grafted with RGD and/or BMPs mimetic peptides

21 January 2018

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Effect of BMP-2 from matrices of different stiffnesses for the modulation of stem cell fate.

21 January 2018

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Biomaterials meet microfluidics: building the next generation of artificial niches

21 January 2018

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Microenvironments engineered by inkjet bioprinting spatially direct adult stem cells toward muscle- and bone-like subpopulations.

21 January 2018

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Synergistic action of static stretching and BMP-2 stimulation in the osteoblast differentiation of C2C12 myoblasts

21 January 2018

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Involvement of BMPs/Smad signaling pathway in mechanical response in osteoblasts

21 January 2018

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Mechanical stress activates Smad pathway through PKCδ to enhance interleukin-11 gene transcription in osteoblasts

21 January 2018

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Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shear

21 January 2018

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Low-intensity pulsed ultrasound enhances BMP-7-induced osteogenic differentiation of human fracture hematoma-derived progenitor cells in vitro

21 January 2018

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Daily low-intensity pulsed ultrasound stimulates production of bone morphogenetic protein in ROS 17/2.8 cells

21 January 2018

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BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway

21 January 2018

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Compressive forces induce osteogenic gene expression in calvarial osteoblasts

21 January 2018

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Mechanical tension-stress induces expression of bone morphogenetic protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis

21 January 2018

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Effects of in vivo mechanical loading on large bone defect regeneration

21 January 2018

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Effect of mechanical stability on fracture healing--an update.

21 January 2018

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Caveolae as plasma membrane sensors, protectors and organizers.

21 January 2018

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Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity.

21 January 2018

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Cells respond to mechanical stress by rapid disassembly of caveolae

21 January 2018

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Imaging actin and dynamin recruitment during invagination of single clathrin-coated pits

21 January 2018

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A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosis

21 January 2018

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Bridging membrane and cytoskeleton dynamics in the secretory and endocytic pathways

21 January 2018

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Actin dynamics counteract membrane tension during clathrin-mediated endocytosis

21 January 2018

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Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry

21 January 2018

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Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1

21 January 2018

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Alphavbeta integrins play an essential role in BMP-2 induction of osteoblast differentiation.

21 January 2018

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Bone morphogenetic protein-2 promotes the haptotactic migration of murine osteoblastic and osteosarcoma cells by enhancing incorporation of integrin beta1 into lipid rafts.

21 January 2018

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Bone morphogenetic protein receptor type II C-terminus interacts with c-Src: implication for a role in pulmonary arterial hypertension

21 January 2018

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Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing.

21 January 2018

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Biochemical and functional characterization of the Ror2/BRIb receptor complex

21 January 2018

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Modulation of GDF5/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2.

21 January 2018

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Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in?

21 January 2018

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The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines

21 January 2018

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Otefin, a nuclear membrane protein, determines the fate of germline stem cells in Drosophila via interaction with Smad complexes

21 January 2018

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Optimal compressive force induces bone formation via increasing bone morphogenetic proteins production and decreasing their antagonists production by Saos-2 cells

21 January 2018

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Reduced expression of BMP-3 due to mechanical loading: a link between mechanical stimuli and tissue differentiation.

21 January 2018

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Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase

21 January 2018

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Mechanical load and BMP signaling during tendon repair: a role for follistatin?

21 January 2018

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Mechanical stretch down-regulates expression of the Smad6 gene in cultured rat mesangial cells.

21 January 2018

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Preliminary characterisation of mechanoresponsive regions of the c-fos promoter in bone cells

21 January 2018

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Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cells

21 January 2018

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Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected]

21 January 2018

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A Smad action turnover switch operated by WW domain readers of a phosphoserine code

21 January 2018

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Role of YAP/TAZ in mechanotransduction

21 January 2018

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TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

21 January 2018

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A new mechanobiological era: microfluidic pathways to apply and sense forces at the cellular level

21 January 2018

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Mechanisms of mechanical signaling in development and disease

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIOF.1137

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29 August 2017

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