Recent progress concerning CpG DNA and its use as a vaccine adjuvant (Q38168903)

30 June 2019

title

Recent progress concerning CpG DNA and its use as a vaccine adjuvant (English)

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30 June 2019

author name string

Hidekazu Shirota

series ordinal

1

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30 June 2019

Dennis M Klinman

series ordinal

2

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30 June 2019

language of work or name

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26 November 2013

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30 June 2019

Expert Review of Vaccines

published in

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30 June 2019

volume

13

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30 June 2019

issue

2

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30 June 2019

page(s)

299-312

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30 June 2019

Approaching the asymptote? Evolution and revolution in immunology

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Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides

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Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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CpG oligodeoxynucleotide and Montanide ISA 51 adjuvant combination enhanced the protective efficacy of a subunit malaria vaccine

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Mucosal administration of CpG oligodeoxynucleotide elicits strong CC and CXC chemokine responses in the vagina and serves as a potent Th1-tilting adjuvant for recombinant gD2 protein vaccination against genital herpes

21 January 2018

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Cost-effectiveness of hepatitis B vaccination using HEPLISAV™ in selected adult populations compared to Engerix-B® vaccine

21 January 2018

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21 January 2018

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21 January 2018

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CpG oligonucleotides improve the protective immune response induced by the anthrax vaccination of rhesus macaques

21 January 2018

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Systemic but not mucosal immunity induced by AVA prevents inhalational anthrax

21 January 2018

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CpG oligodeoxynucleotides adsorbed onto polylactide-co-glycolide microparticles improve the immunogenicity and protective activity of the licensed anthrax vaccine

21 January 2018

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Effect of CpG oligonucleotides on vaccine-induced B cell memory

21 January 2018

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Randomized, double-blind, placebo-controlled, safety and immunogenicity study of 4 formulations of Anthrax Vaccine Adsorbed plus CPG 7909 (AV7909) in healthy adult volunteers.

21 January 2018

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Marked enhancement of the immune response to BioThrax® (Anthrax Vaccine Adsorbed) by the TLR9 agonist CPG 7909 in healthy volunteers.

21 January 2018

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A Phase 1 study of the blood-stage malaria vaccine candidate AMA1-C1/Alhydrogel with CPG 7909, using two different formulations and dosing intervals

21 January 2018

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Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909.

21 January 2018

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Phase 1 trial of the Plasmodium falciparum blood stage vaccine MSP1(42)-C1/Alhydrogel with and without CPG 7909 in malaria naïve adults

21 January 2018

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A randomized and controlled Phase 1 study of the safety and immunogenicity of the AMA1-C1/Alhydrogel + CPG 7909 vaccine for Plasmodium falciparum malaria in semi-immune Malian adults

21 January 2018

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Phase 1 trial of AMA1-C1/Alhydrogel plus CPG 7909: an asexual blood-stage vaccine for Plasmodium falciparum malaria

21 January 2018

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Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity

21 January 2018

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Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA.

21 January 2018

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Use of A-type CpG oligodeoxynucleotides as an adjuvant in allergen-specific immunotherapy in humans: a phase I/IIa clinical trial.

21 January 2018

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Assessment of clinical efficacy of CYT003-QbG10 in patients with allergic rhinoconjunctivitis: a phase IIb study

21 January 2018

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Vaccination with a recombinant protein encoding the tumor-specific antigen NY-ESO-1 elicits an A2/157-165-specific CTL repertoire structurally distinct and of reduced tumor reactivity than that elicited by spontaneous immune responses to NY-ESO-1-ex

21 January 2018

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Vaccination with NY-ESO-1 protein and CpG in Montanide induces integrated antibody/Th1 responses and CD8 T cells through cross-priming.

21 January 2018

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Immunization with analog peptide in combination with CpG and montanide expands tumor antigen-specific CD8+ T cells in melanoma patients

21 January 2018

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Nano-particle vaccination combined with TLR-7 and -9 ligands triggers memory and effector CD8⁺ T-cell responses in melanoma patients

21 January 2018

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Cellular immunity in breast cancer patients completing taxane treatment

21 January 2018

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Phase 1 trial of a CpG oligodeoxynucleotide for patients with recurrent glioblastoma

21 January 2018

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In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: a phase 1/2 study

21 January 2018

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Randomized phase II trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer

21 January 2018

1 reference

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Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-alpha/beta-inducible gene expression, without significant toxicity.

21 January 2018

1 reference

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In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: a phase I/II study

21 January 2018

1 reference

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Phase 1 evaluation of intralesionally injected TLR9-agonist PF-3512676 in patients with basal cell carcinoma or metastatic melanoma

21 January 2018

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The suppressive tumor microenvironment: a challenge in cancer immunotherapy

21 January 2018

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https://api.crossref.org/works/10.1586%2F14760584.2014.863715

Myeloid-derived suppressor cells: linking inflammation and cancer

21 January 2018

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https://api.crossref.org/works/10.1586%2F14760584.2014.863715

Intratumoral injection of CpG oligonucleotides induces the differentiation and reduces the immunosuppressive activity of myeloid-derived suppressor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.863715

Therapeutic potential of Toll-like receptor 9 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.863715

Oligodeoxynucleotide CpG 7909 delivered as intravenous infusion demonstrates immunologic modulation in patients with previously treated non-Hodgkin lymphoma

21 January 2018

1 reference

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Pulmonary and cutaneous vasculitis following hepatitis B vaccination

21 January 2018

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https://api.crossref.org/works/10.1586%2F14760584.2014.863715

Induction of immune-mediated glomerulonephritis in normal mice immunized with bacterial DNA.

21 January 2018

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Theoretical and experimental approaches to generalized autoimmunity

21 January 2018

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Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA.

21 January 2018

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Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity

21 January 2018

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Toll-like receptor 9 in murine lupus: more friend than foe!

21 January 2018

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Therapeutic administration of a synthetic CpG oligodeoxynucleotide triggers formation of anti-CpG antibodies

21 January 2018

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https://api.crossref.org/works/10.1586%2F14760584.2014.863715

CpG motifs in bacterial DNA trigger direct B-cell activation

21 January 2018

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Liposomes to target the lymphatics by subcutaneous administration

21 January 2018

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Enhanced hepatitis C virus NS3 specific Th1 immune responses induced by co-delivery of protein antigen and CpG with cationic liposomes

21 January 2018

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Systemic administration of LPD prepared with CpG oligonucleotides inhibits the growth of established pulmonary metastases by stimulating innate and acquired antitumor immune responses

21 January 2018

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Multifunctional nanorods for gene delivery

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Induction of systemic and mucosal immune responses by intranasal administration of alginate microspheres encapsulated with tetanus toxoid and CpG-ODN.

21 January 2018

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Alginate-coated chitosan nanogel capacity to modulate the effect of TLR ligands on blood dendritic cells

21 January 2018

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21 January 2018

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Enhancement of immune responses by co-delivery of a CpG oligodeoxynucleotide and tetanus toxoid in biodegradable nanospheres

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.863715

PLGA-polymer encapsulating tumor antigen and CpG DNA administered into the tumor microenvironment elicits a systemic antigen-specific IFN-γ response and enhances survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.863715

The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.863715

Efficient in vivo priming by vaccination with recombinant NY-ESO-1 protein and CpG in antigen naive prostate cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.863715

Monophosphoryl Lipid A (MPL) as an Adjuvant for Anti-Cancer Vaccines: Clinical Results

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.863715

Randomized phase III trial of paclitaxel/carboplatin with or without PF-3512676 (Toll-like receptor 9 agonist) as first-line treatment for advanced non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.863715

A phase III randomized study of gemcitabine and cisplatin with or without PF-3512676 (TLR9 agonist) as first-line treatment of advanced non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.863715

Immune response by nasal delivery of hepatitis B surface antigen and codelivery of a CpG ODN in alginate coated chitosan nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2014.863715

Regulation of T-helper type 2 cell and airway eosinophilia by transmucosal coadministration of antigen and oligodeoxynucleotides containing CpG motifs

21 January 2018

1 reference

12 December 2020

Sterically Stabilized Cationic Liposomes Improve the Uptake and Immunostimulatory Activity of CpG Oligonucleotides

1 reference

12 December 2020

A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells

1 reference

12 December 2020

A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant

1 reference

12 December 2020

Effective induction of CD8+ T-cell response using CpG oligodeoxynucleotides and HER-2/neu-derived peptide co-encapsulated in liposomes

1 reference

12 December 2020

Safety and immunogenicity of CPG 7909 injection as an adjuvant to Fluarix influenza vaccine

1 reference

12 December 2020

Induction of systemic TH1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist

1 reference

12 December 2020

CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: a double-blind phase I/II study

1 reference

12 December 2020

Immunotherapy and chemotherapy--a practical partnership

1 reference

12 December 2020

Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis

1 reference

12 December 2020

The role of CpG ODN in enhancement of immune response and protection in BALB/c mice immunized with recombinant major surface glycoprotein of Leishmania (rgp63) encapsulated in cationic liposome.

1 reference

12 December 2020

Phase I trial of toll-like receptor 9 agonist PF-3512676 with and following rituximab in patients with recurrent indolent and aggressive non Hodgkin's lymphoma

1 reference

12 December 2020

1 reference

12 December 2020

Local administration of PF-3512676 CpG-B instigates tumor-specific CD8+ T-cell reactivity in melanoma patients

1 reference

12 December 2020

CpG oligodeoxynucleotides alter lymphocyte and dendritic cell trafficking in humans

1 reference

12 December 2020

BCR-mediated uptake of antigen linked to TLR9 ligand stimulates B-cell proliferation and antigen-specific plasma cell formation

1 reference

12 December 2020

Immunization against leishmaniasis by PLGA nanospheres encapsulated with autoclaved Leishmania major (ALM) and CpG-ODN

1 reference

12 December 2020

CpG blocks immunosuppression by myeloid-derived suppressor cells in tumor-bearing mice

1 reference

12 December 2020

CpG-conjugated apoptotic tumor cells elicit potent tumor-specific immunity

1 reference

12 December 2020

Cholera toxin - a foe & a friend.

1 reference

12 December 2020

Nanoparticles encapsulating hepatitis B virus cytosine-phosphate-guanosine induce therapeutic immunity against HBV infection

1 reference

12 December 2020

Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA

1 reference

12 December 2020

CpG DNA rescue of murine B lymphoma cells from anti-IgM-induced growth arrest and programmed cell death is associated with increased expression of c-myc and bcl-xL.

1 reference

12 December 2020

Do DNA vaccines induce autoimmune disease?

1 reference

12 December 2020

CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen

1 reference

12 December 2020

CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge

1 reference

12 December 2020

Effects of bacterial DNA on cytokine production by (NZB/NZW)F1 mice

1 reference

12 December 2020

CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice.

1 reference

12 December 2020

Suspected hepatitis B vaccination related vasculitis

1 reference

12 December 2020

Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria.

1 reference

12 December 2020

10.1586/14760584.2014.863715

Identifiers

DOI

1 reference

30 June 2019

PMC publication ID

6335645

1 reference

30 June 2019

PubMed publication ID

24308579

1 reference

30 June 2019