Of CARs and TRUCKs: chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma (Q38170498)

30 August 2017

title

Of CARs and TRUCKs: chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma (English)

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30 August 2017

Markus Chmielewski

1

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30 August 2017

Andreas A Hombach

series ordinal

2

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30 August 2017

Hinrich Abken

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3

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30 August 2017

publication date

1 January 2014

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30 August 2017

published in

Immunological Reviews

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30 August 2017

volume

257

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issue

1

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30 August 2017

page(s)

83-90

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Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy

30 August 2017

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Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo

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IL-12 release by engineered T cells expressing chimeric antigen receptors can effectively Muster an antigen-independent macrophage response on tumor cells that have shut down tumor antigen expression

21 January 2018

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Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning

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Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts

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Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis

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Autologous and MHC class I-negative allogeneic tumor cells secreting IL-12 together cure disseminated A20 lymphoma

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The third signal cytokine IL-12 rescues the anti-viral function of exhausted HBV-specific CD8 T cells

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IL-12 can alleviate Th17-mediated allergic lung inflammation through induction of pulmonary IL-10 expression

21 January 2018

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New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions

21 January 2018

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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

21 January 2018

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IL-23 promotes tumour incidence and growth

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Interleukin-18 gene transfer increases antitumor effects of suicide gene therapy through efficient induction of antitumor immunity

21 January 2018

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Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation

21 January 2018

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Nitric oxide short-circuits interleukin-12-mediated tumor regression.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/IMR.12125

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30 August 2017

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